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| Number | Title | Issue Date |
| 8187807 | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular,... | 05/29/2012 |
| 8187808 | Barriers for facilitating biological reactions The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and... | 05/29/2012 |
| 8178297 | Method of detecting canine exercise-induced collapse The present invention relates to diagnosing Canine Exercise-Induced Collapse (EIC). ... | 05/15/2012 |
| 8178296 | Methods and reagents for preserving RNA in cell and tissue samples This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished without ul... | 05/15/2012 |
| 8178300 | Method for the identification of the clonal source of a restriction fragment The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restrictio... | 05/15/2012 |
| 8173371 | Serial coupling of nucleic acid metabolism and extension for nucleic acid amplification A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3... | 05/08/2012 |
| 8168388 | Preparation of nucleic acid templates for solid phase amplification The invention relates to a method of preparing template constructs for solid-phase nucleic acid amplification and to use of the templates in methods of solid-phase nucleic acid amplification. The method involves carrying out two ligation reactions: (a) a ligation re... | 05/01/2012 |
| 8168384 | Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a... | 05/01/2012 |
| 8163523 | Cell-based systems for producing influenza vaccines The present invention relates to a cell-based method for producing influenza virus vaccines by enriching the population of surface-bound α2,6-sialic acid receptors on a cell surface, such as on a Chinese Hamster Ovary (CHO) cell surface. The host cell therefore pre... | 04/24/2012 |
| 8163483 | Compositions and methods for spinocerebellar ataxia Mutations in the KCNC3 (Kv3.3) voltage-gated potassium channel gene result in spinocerebellar ataxia. ... | 04/24/2012 |
| 8163485 | Differential enzymatic fragmentation The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids. ... | 04/24/2012 |
| 8163488 | Methods and nucleic acids for analysis of colon proliferative disorders The invention provides methods, nucleic acids and kits for detecting colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of ... | 04/24/2012 |
| 8158349 | Method and device for purifying nucleic acids The invention concerns a method for isolating and purifying nucleic acids from a sample and a device that is suitable therefore. ... | 04/17/2012 |
| 8158588 | Loop-variant PDZ domains as biotherapeutics, diagnostics and research reagents The present invention provides polypeptides that contain one or more PDZ loop-variants and are useful in the detection of pathogens and disease-associated molecules. The polypeptides of the invention are also useful in the diagnosis, treatment, and prevention of dis... | 04/17/2012 |
| 8153366 | Methods and compositions for predicting drug responses The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes deri... | 04/10/2012 |
| 8153375 | Compositions and methods for nucleic acid sequencing Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and an... | 04/10/2012 |
| 8153369 | Assessment of risk for colorectal cancer Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP). ... | 04/10/2012 |
| 8148114 | Materials and methods for treatment of inflammatory and cell proliferation disorders Compositions and methods for treatment of inflammatory and cell proliferation disorders using natriuretic hormone peptide (NP), polynucleotides encoding NP, or agents that reduce the activity of atrial natriuretic peptide receptor A (NPR-A). ... | 04/03/2012 |
| 8148066 | Method of nucleic acid hybridization The present invention relates to a nucleic acid hybridization method and in particular to a method using a microfluidic chip-based hybridization device with modified procedures which shows the advantages of simplicity and efficiency. The method of the present invent... | 04/03/2012 |
| 8148115 | Device and method for extraction and analysis of nucleic acids from biological samples Device and methods for extracting and analyzing nucleic acids from biological samples. ... | 04/03/2012 |
| 8143001 | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates to methods for fragmentation and/or labeling and/or immobilization of... | 03/27/2012 |
| 8143000 | Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingu... | 03/27/2012 |
| 8143008 | Method of nucleic acid amplification A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other prim... | 03/27/2012 |
| 8137910 | Method of regulating gene expression The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method. ... | 03/20/2012 |
| 8133701 | Detection and quantification of biomolecules using mass spectrometry The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleo... | 03/13/2012 |
| 8133702 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the n... | 03/13/2012 |
| 8124335 | Compositions and assays to detect influenza virus A and B nucleic acids Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic ac... | 02/28/2012 |
| 8119341 | Genetic variant of the annexin A5 gene The present invention relates to a nucleic acid molecule comprising an annexin A5 (ANXA5) gene regulation element which comprises at least one point mutation, whereby said at least one point mutation (substitution) is selected from the group consisting of (i) a poin... | 02/21/2012 |
| 8119343 | Method for identifying oculoskeletal dysplasia in dogs Provided are methods for identifying dogs as likely to be genetically normal, carriers of, or affected with Oculo-skeletal dysplasia (OSD) by determining the presence or absence of a drd2 COL9A2 mutation and/or a drd1 COL9A3 mutation. Also provided is a method for s... | 02/21/2012 |
| 8114636 | Labeling and detection of nucleic acids Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling nucleic acids with an azide group. ... | 02/14/2012 |
| 8114600 | Genetic markers of schizophrenia endophenotypes This document provides methods and materials related to genetic markers of schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD), (collectively referred to herein as “schizophrenia spectrum disorders” or SSDs). For exam... | 02/14/2012 |
| 8110355 | Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modul... | 02/07/2012 |
| 8105781 | Predictors of long-term mortality following coronary artery bypass graft surgery The present invention relates, in general, to perioperative depression and, in particular, to methods of identifying individuals at risk of perioperative depression. ... | 01/31/2012 |
| 8105780 | Device and method of detecting mutations and polymorphisms in DNA There is provided a resonator sensor useful for detecting polymorphisms and mutations in DNA. The resonator sensor has a capture molecule immobilised on its surface, the capture molecule being either a probe DNA containing a reference sequence, or a mismatch binding... | 01/31/2012 |
| 8105784 | Method for pairwise sequencing of target polynucleotides The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods... | 01/31/2012 |
| 8101385 | Materials and methods for the generation of transcripts comprising modified nucleotides Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. ... | 01/24/2012 |
| 8097410 | Methods and compositions for vitamin K epoxide reductase The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymor... | 01/17/2012 |
| 8097413 | Detection of group B The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting... | 01/17/2012 |
| 8093001 | Detection and diagnosis of smoking related cancers Gene probes for specific regions of chromosome 3 (3p21.3) and chromosome 10 (10q22) have been found to be tools for the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluoresc... | 01/10/2012 |
| 8093003 | Fluorescence energy transfer by competitive hybridization A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which hav... | 01/10/2012 |
