Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7435574 | NADH oxidase from The present invention is directed to a new NADH oxidase from Lactobacillus, nucleic acids encoding the NADH oxidase, methods of producing the NADH oxidase, as well as there use in producing improved NADH oxidase enzymes and for producing chrial enantiomer-enr... | 10/14/2008 |
| 7432246 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 10/07/2008 |
| 7378259 | Fluid processing device A fluid processing device and method of using the device are provided. The fluid processing device can include a substrate with a fluid processing pathway at least partially formed in or on the substrate. The fluid processing pathway can include an input end, at lea... | 05/27/2008 |
| 7084264 | Viral sequences An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, or the full complementary sequence thereof. Presence of said nucleic acid in a subject predisposes the subject to an adenocarcinoma. Also disclosed are a method of diagnosing an adenocarcino... | 08/01/2006 |
| 7074596 | Synthesis and use of anti-reverse mRNA cap analogues The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a variety of applications. However, one-third to one-half of the caps have, until now, been incorporated in the reverse orientation. Such reverse caps impair the translation ... | 07/11/2006 |
| 6987091 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 01/17/2006 |
| 6974865 | C3′ -methylene hydrogen phosphonate oligomers and related compounds The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, me... | 12/13/2005 |
| 6958245 | Array cytometry A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on t... | 10/25/2005 |
| 6951931 | Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides inte... | 10/04/2005 |
| 6900301 | Backbone modified oligonucleotide analogues Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and pol... | 05/31/2005 |
| 6875621 | Magnetizable bead detector A ferromagnetic thin-film based magnetic field detection system used for detecting the presence of selected molecular species. A magnetic field sensor supported on a substrate has a binding molecule layer positioned on a side thereof capable of selectively binding t... | 04/05/2005 |
| 6830907 | Mutants of Mycobacterium vaccae-derived formate dehydrogenase and uses thereof An objective of the present invention is to provide polypeptides capable of retaining a strong enzyme activity of formate dehydrogenase in the presence of an organic solvent and to provide the uses thereof. Formate dehydrogenase mutant polypeptides, which are... | 12/14/2004 |
| 6800743 | Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides interm... | 10/05/2004 |
| 6737257 | Hyperthermophilic enzymes for industrial chemical redox reactions: a method for biofuel ethanol production The present invention is directed to use of hyperthermophilic enzymes for industrial chemical redox reactions such as ethanol production. The present invention is especially useful for the coupled synthesis and recovery of alcohols whereby recovery of alcohol is sim... | 05/18/2004 |
| 6593090 | High resolution DNA detection methods and devices The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact ... | 07/15/2003 |
| 6514771 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces ... | 02/04/2003 |
| 6504024 | Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 i... | 01/07/2003 |
| 6414127 | Pyrimidine derivatives for labeled binding partners Compounds having structure (1) ##STR1## wherein R1 is --H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make th... | 07/02/2002 |
| 6399303 | High resolution DNA detection methods and devices The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact ... | 06/04/2002 |
| 6251691 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces rel... | 06/26/2001 |
| 6248568 | Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 i... | 06/19/2001 |
| 6242234 | Mutants of formate dehydrogenase from Candida boidinii, new gene sequences encoding these and use of the new formate dehydrogenases The invention relates to new mutants of formate dehydrogenase from Candida boidinii, new gene sequences encoding these and use of the new formate dehydrogenases. The wild type FDH used hitherto in the industrial process for preparing amino acids becomes i... | 06/05/2001 |
| 6060023 | Molecular sensing apparatus A molecular sensing apparatus comprises a first electrode (10), a second electrode (12), a first molecule (20), a second molecule (22), and a third molecule (34). The first molecule (20) has a first chain of nucleic bases (30) and a first group (24). The ... | 05/09/2000 |
| 6028183 | Pyrimidine derivatives and oligonucleotides containing same Compounds having structure (1) ##STR1## wherein R1 is --H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods ma... | 02/22/2000 |
| 6017696 | Methods for electronic stringency control for molecular biological analysis and diagnostics A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, an... | 01/25/2000 |
| 6007992 | Pyrimidine derivatives for labeled binding partners Compounds having structure (1) ##STR1## wherein R1 is --H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods ma... | 12/28/1999 |
| 5866378 | Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses The present invention relates to processes for the enzymatic synthesis of nucleotide-6-deoxy-D-xylo-4-hexuloses starting from a nucleoside monophosphate (NMP). These processes comprise simultaneous incubation of the following substances in a buffer soluti... | 02/02/1999 |
| 5753787 | Nucleic acids encoding ancylostoma secreted protein A protein, Ancylostoma Secreted Protein (ASP), that is released by hookworm larvae following infection, and which is highly immunogenic in experimental animals, is disclosed. Nucleic acids encoding ASP, antibodies recognizing ASP, and methods of detecting... | 05/19/1998 |
| 5750389 | Purified saccharose-synthase, process for its production and its use Nucleotide sugars, especially UDP, ADP, CDP or TDP saccharoses can be enzymatically obtained by the reaction of nucleoside diphosphates with di or trisaccharides with a saccharose synthase in which the virtual absence of nucleoside phosphatases (0.1% or l... | 05/12/1998 |
| 5610289 | Backbone modified oligonucleotide analogues Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique ... | 03/11/1997 |
| 5605662 | Active programmable electronic devices for molecular biological analysis and diagnostics A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, ant... | 02/25/1997 |
| 5587128 | Mesoscale polynucleotide amplification devices Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction chamber, havi... | 12/24/1996 |
| 5538867 | Process for the electrochemical regeneration of pyridine cofactors The present invention relates to a process for the electrochemical regeneration of pyridine cofactors. The process of the invention is characterized by the use, in a reaction medium subjected to electrolysis, of a cytoplasmic hydrogenase enzyme.... | 07/23/1996 |
| 5334514 | Process for the production of activated sialic acids The invention relates to a process for the production of cytidine 5'-monophosphosialic acids which comprises reacting a sialic acid with cytidine 5'-triphosphate in the presence of a cell extract of a naturally occurring microorganism having cytidine 5'-m... | 08/02/1994 |
| 5306629 | Method for producing dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof A method for producing a dinucleoside polyphosphate, a nucleoside polyphosphate or a derivative thereof which comprises using adenosine-5'-triphosphate, polyphosphate or a derivative thereof and a sulfate as reaction substrates and forming a dinucleoside ... | 04/26/1994 |
| 5283181 | Conjugated enzyme electrode A conjugated enzyme electrode comprising diaphorase and an amino-acid dehydrogenase immobilized on a conductive support by a polyfunctional aldehyde is disclosed, by which amino acids can be rapidly determined with high sensitivity.... | 02/01/1994 |
| 5266463 | Highly sensitive assay method for L-carnitine and composition for practicing same A method of assaying L-carnitine in a specimen comprises reacting a specimen containing L-carnitine with: a) L-carnitine dehydrogenase having coenzymes of the thio-NAD group and of the NAD group, and which catalyzes a reversible reaction forming dehydroca... | 11/30/1993 |
| 5250416 | Method for highly sensitive determination of NADH using kinase The present invention relates to a method for determining a slight amount of NADH or XTP which is present in a solution, with high sensitivity by the use of an NADH kinase specific for NADH by utilizing a cycling reaction, and this method permits highly s... | 10/05/1993 |
| 5185441 | DNA sequences, recombinant DNA molecules and processes for producing PI-linked lymphocyte function associated antigen-3 Polypeptides that bind to CD2, the receptor on the surface of T-lymphocytes. Most preferably, the polypeptides are soluble. DNA sequences that code on expression and/or secretion in appropriate unicellular hosts for those polypeptides.... | 02/09/1993 |
| 5149640 | Method for producing galactose transfer products A galactose transfer product is prepared by a process of allowing a microorganism capable of producing a galactose transfer product of the formula: (Gal)n --R, wherein Gal represents a galactose residue, n represents an integer of 1 to 4 and R ... | 09/22/1992 |
