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| Number | Title | Issue Date |
| 7439043 | Galactosyl nucleotide sugars The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide. ... | 10/21/2008 |
| 7399613 | Sialic acid nucleotide sugars The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide. ... | 07/15/2008 |
| 7378259 | Fluid processing device A fluid processing device and method of using the device are provided. The fluid processing device can include a substrate with a fluid processing pathway at least partially formed in or on the substrate. The fluid processing pathway can include an input end, at lea... | 05/27/2008 |
| 7355045 | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids. ... | 04/08/2008 |
| 7344864 | clipped (cFRT) chromosome insensitive to transposage, generating method thereof, and application thereof A method for generating a Drosophila clipped FRT (cFRT) chromosome is provided, wherein the chromosome is insensitive to a P transposase but remains functional to a yeast site-specific flippase recombinase (FLP). The method includes steps of: (a) exposing a F... | 03/18/2008 |
| 7335496 | Method for producing target substance A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modif... | 02/26/2008 |
| 7329522 | Polyphosphate:AMP phosphotransferase This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties: (A) action: catalyzing of the following two reactions: NMP+PolyP(n)→NDP+PolyP | 02/12/2008 |
| 7326546 | Purine-derived substance-producing bacterium and a method for producing purine-derived substance A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in t... | 02/05/2008 |
| 7270980 | Compounds for immunodiagnosis of prostate cancer and methods for their use Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and moni... | 09/18/2007 |
| 7241587 | Method of uncoupling the catabolic pathway of glycolysis from the oxidative membrane bound pathway of glucose conversion The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention provides host cells having a modification in nucleic acid encoding a... | 07/10/2007 |
| 7238338 | System and method for the large scale labeling of compounds with radiohalogens Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments specific to pyrimidines includes dissolving a halogenated pyrimidine to ... | 07/03/2007 |
| 7223581 | FF-ATPase and DNA encoding the same Provided are a protein complex having the F0F1-ATPase activity; a DNA encoding the protein complex; a method for producing the protein complex, using the DNA; and a method for producing nucleoside 5′-triphosphate using the protein. The presen... | 05/29/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
| 7189542 | clipped FRT (cFRT) chromosome insensitive to transposase, generating method thereof, and application thereof A method for generating a Drosophila clipped FRT (cFRT) chromosome is provided, wherein the chromosome is insensitive to a P transposase but remains functional to a yeast site-specific flippase recombinase (FLP). The method includes steps of: (a) exposing a F... | 03/13/2007 |
| 7148042 | Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group... | 12/12/2006 |
| 7141397 | Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group... | 11/28/2006 |
| 7141396 | Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group... | 11/28/2006 |
| 7122333 | Method and reagent for visually measuring ATP The object of the invention is to provide a handy type visually determinable ATP measuring reagent which can be easily handled and has good measuring sensitivity. The invention is an ATP measuring reagent which rendered possible visual determination by amplifying th... | 10/17/2006 |
| 7084264 | Viral sequences An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, or the full complementary sequence thereof. Presence of said nucleic acid in a subject predisposes the subject to an adenocarcinoma. Also disclosed are a method of diagnosing an adenocarcino... | 08/01/2006 |
| 7038039 | Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase,... | 05/02/2006 |
| 7018824 | Mannosyl transfer with regeneration of GDP-mannose A one-pot glycosylation reaction is disclosed in which a mannosyl (Man) group is enzymatically transferred to an acceptor molecule. The starting glycoside is a mannosyl 1-phosphate that is enzymatically converted to its GDP derivative via UTP and a pyrophorylase. Th... | 03/28/2006 |
| 6991924 | Mutant carbamoylphosphate synthetase and method for producing compounds derived from carbamoylphosphate L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5′-monophosphate (UMP), cytidine and cytidine 5′-monophosphate (CMP) are produced using a bacterium belonging to the genus Escherichia harboring a mutant carbamoylph... | 01/31/2006 |
| 6987008 | Variant nucleoside-5′-phosphate producing enzyme There is provided a mutant nucleoside-5′-phosphate producing enzyme with improved nucleoside-5′-phosphate producing ability of a nucleoside-5′-phosphate producing enzyme that has transphosphorylation activity and/or phosphatase activity and has one Lys residue... | 01/17/2006 |
| 6962804 | Drosophila clipped FRT (cFRT) chromosome insensitive to P transposase, generating method thereof, and application thereof A method for generating a Drosophila clipped FRT (cFRT) chromosome is provided, wherein the chromosome is incapable of reacting with a P transposase but remains capable of reacting with a yeast site-specific flippase recombinase (FLP). The method includes ste... | 11/08/2005 |
| 6955892 | Feeding processes for fermentation Embodiments of the present invention generally relate to novel fed-batch fermentations wherein processes of DO-stat and pH-stat are combined for nutrient feeding control. ... | 10/18/2005 |
| 6919440 | Mannosyl transfer with regeneration of GDP-mannose A one-pot glycosylation reaction is disclosed in which a mannosyl (Man) group is enzymatically transferred to an acceptor molecule. The starting glycoside is a mannosyl 1-phosphate that is enzymatically converted to its GDP derivative via UTP and a pyrophorylase. Th... | 07/19/2005 |
| 6916616 | Stabilized aqueous nucleoside triphosphate solutions The invention concerns stable aqueous solutions containing one or several nucleoside triphosphates wherein the respective solution has a pH value of more than 7.5 and contains no additional substances with a stabilizing effect. The nucleoside triphosphate solutions ... | 07/12/2005 |
| 6906185 | Derivatives of 7-deaza -2′-deoxyguanosine-5'-triphosphate, preparation and use thereof Derivatives of 7-deaza-2′-deoxyguanosine are described. Also described is the use of such compounds in synthesis of nucleic acid polymers and in methods for determining a nucleotide base sequence. ... | 06/14/2005 |
| 6884880 | Process for the preparation of 9-β-anomeric nucleoside analogs A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-β-D- or L-purine nucleoside analog... | 04/26/2005 |
| 6884604 | Glycorandomization and the production of novel erythronolide and coumarin analogs The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be ... | 04/26/2005 |
| 6875591 | Process for producing GDP-fucose Processes for producing GDP-fucose, comprising allowing GKDM and a culture broth of a microorganism capable of converting GKDM into GDP-fucose to be present in an aqueous medium, forming and accumulating GDP-fucose therein, and recovering the GDP-fucose therefrom; o... | 04/05/2005 |
| 6872818 | Ammonium sulfate for neutralization of inhibitory effects The present invention provides RNA purification and/or analysis methods that use ammonium sulfate to mitigate or neutralize inhibitory effects of certain molecules. Exemplary inhibitory molecules that interfere with RNA function or analysis are those that bind to or... | 03/29/2005 |
| 6858721 | Method for producing cytosine nucleoside compounds The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a ... | 02/22/2005 |
| 6855520 | Cell volume-regulated human kinase h-sgk The present invention relates to the cloning and characterization of a human serine/threonine kinase (h-sgk: serum and glucocorticoid dependent kinase). The invention furthermore relates to reagents for diagnosing conditions associated with a change in cell volume a... | 02/15/2005 |
| 6821756 | Processes for reproducing sugar nucleotides and complex carbohydrates This invention relates to a process for producing a sugar nucleotide, in which a) a culture broth of a microorganism capable of producing NTP from a nucleotide precursor, or a treated product of the culture broth, and b) a culture broth of a microorganism capable of... | 11/23/2004 |
| 6818394 | High density immobilization of nucleic acids Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nu... | 11/16/2004 |
| 6753154 | Human AZU-1 gene, variants thereof and expressed gene products A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, ... | 06/22/2004 |
| 6673576 | Process for producing nucleic acids The present invention relates to a process for producing 5'-inosinic acid or 5'-guanylic acid for use in seasonings or the like from inosine or guanosine or a precursor thereof using an adenosine triphosphate (ATP)-regenerating microorganism containing a ... | 01/06/2004 |
| 6664078 | Method for the isolation of ccc plasmid DNA The present invention relates to the production of biomass for the isolation of ccc plasmid DNA comprising culturing a bacterial transformant in a bioreactor containing an antibiotic-free batch medium under batch-conditions and, at the end of the batch ph... | 12/16/2003 |
| 6660275 | Chlamydia antigens and corresponding DNA fragments and uses thereof The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequenc... | 12/09/2003 |
