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| Number | Title | Issue Date |
| 7375088 | Polyene polyketides, processes for their production and their use as a pharmaceutical This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensi... | 05/20/2008 |
| 7294486 | Enzymatic process for the synthesis of organo-fluorine compounds There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18F labelled fluoronucleoside comp... | 11/13/2007 |
| 7189558 | Process for producing pravastatin sodium salt using dsm 14455 In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens. ... | 03/13/2007 |
| 7112432 | Process for producing cis-3-hydroxy-L-proline An isolated gene encodes for a L-proline-3-hydroxylase having the amino acid sequence of SEQ ID NOS: 1, 2, 15, 16 and 17, or for a protein having enzymatic activity to hydroxylate the 3-position of L-proline and to act on free L-proline in the presence of 2-ketoglut... | 09/26/2006 |
| 7101695 | Method of producing transglutaminase having broad substrate activity Embodiments of the invention generally provide methods and compositions for producing recombinant transglutaminases. The purified recombinant transglutaminases of the invention are reactive to a broad range of compounds and exhibit broad substrate activity. In one e... | 09/05/2006 |
| 7078195 | Antibiotics AA-896 This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-Bl, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-8... | 07/18/2006 |
| 6930130 | Citrullimycines, a process for their production and their use as pharmaceuticals The present invention relates to novel active compounds named Citrullimycines, which are obtainable by cultivation of Streptomyces sp. ST 101396 (DSM 13309), and to their pharmaceutically acceptable salts and derivatives. The present invention further relates... | 08/16/2005 |
| 6878532 | Method of producing phosphatidylserine A novel method of producing PS is described herein. The method first involves producing PLD enzyme through the use of enzyme-producing microorganisms. The PLD enzyme is reacted with a lecithin and source of serine to produce the phosphatidylserine (PS). The method d... | 04/12/2005 |
| 6852317 | Metabolite from streptomyces strain NRRL accession No. B-30145 and mutants thereof for controlling plant diseases A novel antibiotic-producing Streptomyces sp. is provided that exhibits antifungal activity only on certain specific plant pathogens. Also provided is a method of treating or protecting plants from fungal infections comprising applying an effective amount of ... | 02/08/2005 |
| 6780616 | Antibiotic caprazamycins and process for producing the same There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) wherein R is tridecyl group, 11-methyl... | 08/24/2004 |
| 6767533 | Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress. ... | 07/27/2004 |
| 6696412 | High purity lipopeptides, Lipopeptide micelles and processes for preparing same The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interact... | 02/24/2004 |
| 6664100 | Conversion of organic waste into humic products using multiple aerobic fermentations for soils restoration A method for converting organic solid waste into humic products and the corresponding apparatus, in which a preliminary aerobic fermentation of the organic solid waste is performed, followed by a second aerobic fermentation of the organic waste in the pre... | 12/16/2003 |
| 6638503 | STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME The present invention relates to a novel microorganism Streptomyces megasporus SD5. The present invention also relates to a process for the isolation of said Streptomyces megasporus SD5. The invention also relates to a novel fibrinolytic enzyme actinokina... | 10/28/2003 |
| 6566106 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 05/20/2003 |
| 6524577 | Strain of Streptomyces for controlling plant diseases A novel antibiotic-producing Streptomyces sp. is provided that exhibits antifungal activity only on certain specific plant pathogens. Also provided is a method of treating or protecting plants from fungal infections comprising applying an effective amount... | 02/25/2003 |
| 6509184 | Alkaline tolerant dextranase from streptomyces anulatus A process for production of an alkaline tolerant dextranase enzyme comprises culturing a dextran-producing microorganism Streptomyces anulatus having accession no. ATCC PTA-3866 to produce an alkaline tolerant dextranase, Dex 1 wherein the protein in said... | 01/21/2003 |
| 6465203 | Glucan-containing compositions and paper The present invention provides methods of making paper, utilizing glucans, produced by the glucosyltransferase B, C or D enzyme of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to currently ut... | 10/15/2002 |
| 6455270 | Method for inhibiting eukaryotic protein kinases Lichen-derived organic acids such as vulpinic acid and usnic acid have been found to be effective inhibitors of eukaryotic protein kinase activity. Thus, eukaryotic protein kinase activity present in a sample or organism can be inhibited by adding to the ... | 09/24/2002 |
| 6432688 | Amino alcohol dehydrogenase converts keto alcohol to amino alcohol and amino alcohol to keto alcohol A purified amino alcohol dehydrogenase which reductively converts a keto alcohol into an amino alcohol and oxidatively converts an amino alcohol into a keto alcohol is disclosed. The enzyme is NAD(H) dependent, has a molecular weight of 100,000 Da when de... | 08/13/2002 |
| 6297043 | Mumbaistatin, a process for it's production and its use as a pharmaceutical The present invention relates to a compound named Mumbaistatin, its pharmaceutically acceptable salts and derivatives, a process for its production, and its use as a pharmaceutical. Mumbaistatin is obtainable by cultivation of the microorganism HIL-008003... | 10/02/2001 |
| 6284479 | Substitutes for modified starch and latexes in paper manufacture The present invention provides methods of making paper, utilizing glucans, produced by the glucosyltransferase B, C or D enzyme of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to currently ut... | 09/04/2001 |
| 6280719 | Antifungal biocontrol agents, a process for preparing and treating the same The present invention relates to antifungal biocontrol agents which enhance plant growth and reduce plant diseases by suppressing fungal pathogens, and the manufacturing and application methods thereof. The antifungal biocontrol agents of the present inve... | 08/28/2001 |
| 6235506 | Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.... | 05/22/2001 |
| 6207428 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 03/27/2001 |
| 6132984 | Method for inhibiting eukaryotic protein kinases Lichen-derived organic acids such as vulpinic acid and usnic acid have been found to be effective inhibitors of eukaryotic protein kinase activity. Thus, eukaryotic protein kinase activity present in a sample or organism can be inhibited by adding to the ... | 10/17/2000 |
| 6110726 | Actinomycete strains of ATCC 55984 and uses thereof for growth enhancement and control of pathogen infection in plants One or more identified biologically pure strains of Actinomycete isolated from ATCC 55984 and methods of using the strains. The strains are used to confer protection against plant pathogen infection in a susceptible plant and are also used to enhance grow... | 08/29/2000 |
| 6103504 | Process for production of avermectins and cultures therefor This invention relates to Streptomyces avermitilis lacking branched-chain amino acid transaminase activity, branched-chain 2-oxo acid biosynthetic activity and, optionally and preferably, avermectin B-O-methyl transferase activity, methods for preparation... | 08/15/2000 |
| 6100052 | Process for the production of clavulanic acid and/or salts thereof by fermentation controlling soluble phosphate concentration A batch fermentation is carried out continuously or semicontinuously using strain of Streptomyces clavuligerus for the production of clavulanic acid. The fermentation process is carried out with strict control of the soluble phosphate in the medium both a... | 08/08/2000 |
| 6074638 | Composition and method for inhibiting plant disease The present invention is directed to methods and compositions for biological control of plant diseases using suppressive avirulent strains of Streptomyces spp. to control disease on a vegetable or other susceptible crop. The method includes applying one o... | 06/13/2000 |
| 6066492 | Microorganism capable of degrading polylactic acid resin and method of degrading polylactic acid resin using said microorganism A microorganism belonging to the genus Staphylococcus or the genus Streptomyces which is capable of degrading a polylactic acid resin. A method of degrading a polylactic acid resin including a step of culturing a microorganism capable of degrading a polyl... | 05/23/2000 |
| 6043064 | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof An enzymatic hydroxylation process for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors uses a microorganism or an enzyme derived from, or having the structure o... | 03/28/2000 |
| 5985624 | Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.... | 11/16/1999 |
| 5985625 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microogranism comprises the microfiltration of the broth without pr... | 11/16/1999 |
| 5976855 | Method of preparing a variant of a lipolytic enzyme The present invention relates to a method of preparing a variant of a parent lipolytic enzyme, comprising (a) subjecting a DNA sequence encoding the parent lipolytic enzyme to random mutagenesis, (b) expressing the mutated DNA sequence obtained in step (a... | 11/02/1999 |
| 5965445 | Polycyclic ether antibiotic having anthelmintic, anticoccidial and growth promotant activity An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 55028. This novel antibiotic is useful as an anticoccidial in chickens, in the preventi... | 10/12/1999 |
| 5965604 | Chrolactomycin compound The present invention relates to chrolactomycin compound represented by the following formula (I): ##STR1## or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.... | 10/12/1999 |
| 5939399 | Polyene antibiotics, 3874 H1 to H6, processes for their preparation and use Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use which are suitable for treating fungal diseases, trichomonad diseases, and for treating diseases associated with an increased steroid concentration.... | 08/17/1999 |
| 5919672 | Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)-(S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4 -hydroxyphenyl)-2-azetidinone A process for the microbiological or enzymatic hydrolytic resolution of racemic trans-2-(alkoxycarbonylethyl) lactams of the formula I: ##STR1## wherein R is C1 -C7 alkyl, 2,2,2-trifluoroethyl or methoxyethoxyethyl and R1 | 07/06/1999 |
| 5905034 | Method for precipitating natural avermectins A process for separating a natural B avermectin from a natural avermectin containing fermentation broth by using an aqueous precipitation. The process comprises extracting natural avermectins from the fermentation broth with a water miscible solvent and a... | 05/18/1999 |
