William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| RE40023 | Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use A pharmaceutical composition containing several different bacteria including Streptococcus thermophilus, Lactobacilli and Bifidobacteria is disclosed. The bacteria are present in the composition at a total concentration of 1×1011 to 1×1013 pe... | 01/22/2008 |
| 7223591 | Strain of lactic acid bacterium and edible compositions, drugs and veterinary products containing it Describes a new strain of Streptococcus thermophilus ssp. salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drug... | 05/29/2007 |
| 7078061 | Methods, compositions and kits for biomarker extraction The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods, kits, reagents and compositions for measuring a plurality of different ... | 07/18/2006 |
| 7018807 | Method and medium for detecting vancomycin-resistant A microbe-specific medium for detection of vancomycin-resistant Enterococci in a test sample within 24 hours and preferably within 18 hours. The testing medium provides a selective growth medium for vancomycin-resistant Enterococci and includes specifi... | 03/28/2006 |
| 6897037 | Pre-treatment kit for saliva and pre-treatment method for saliva using the same To provide a pre-treatment kit for saliva and a pre-treatment method for saliva for identification and quantitation of mutans streptococci in human saliva by the immunochromatographic method, which can eliminate mucin in saliva and prevent mutans streptococci from c... | 05/24/2005 |
| 6582695 | Sphingomyelinase compositions and use thereof The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.... | 06/24/2003 |
| 6541027 | Lactic acid bacteria with anxiolytic properties and uses thereof The invention concerns lactic acid bacteria with anxiolytic properties and not inducing sedative effect. Said lactic acid bacteria are useful in particular for preparing foods or medicines.... | 04/01/2003 |
| 6465203 | Glucan-containing compositions and paper The present invention provides methods of making paper, utilizing glucans, produced by the glucosyltransferase B, C or D enzyme of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to currently ut... | 10/15/2002 |
| 6444203 | Administering bacteria to improve sleep A method of improving sleep in a mammal having a sleep disorder is disclosed. The method includes identifying the mammal having a sleep disorder and then administering Lactobacillus acidophilus CNCM I-2274, Lactobacillus acidophilus CNCM I-2132, Lactobaci... | 09/03/2002 |
| 6368591 | Beneficial microbe composition, new protective materials for the microbes, method to prepare the same and uses thereof This invention provides a microbe composition comprising three viable and beneficial lactic acid producing bacteria of new strains: Bifidobacterium longum 6-1 (CCTCC Number M 98003), Lactobacillus acidophilus YIT 2004 (CCTCC Number M 98004) and Sterptococ... | 04/09/2002 |
| 6355449 | Method and medium for detecting vancomycin-resistant enterococcus A microbe-specific medium for detection of vancomycin-resistant Enterococci in a test sample within 24 hours and preferably within 18 hours. The testing medium provides a selective growth medium for vancomycin-resistant Enterococci and includes specific n... | 03/12/2002 |
| 6319895 | Lactoferrin tablets Lactoferrin tablets comprising as the active ingredients lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg; and lactoferrin tablets comprising as the active ingredients a microbial cell po... | 11/20/2001 |
| 6284479 | Substitutes for modified starch and latexes in paper manufacture The present invention provides methods of making paper, utilizing glucans, produced by the glucosyltransferase B, C or D enzyme of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to currently ut... | 09/04/2001 |
| 6242210 | Treatment of bacterial infections An assay for compounds useful in the treatment of a bacterial induced coagulation disorder has the following steps: a) incubating a plasma sample with a strain of bacteria; b) adding a compound to be assayed to the plasma sample before, during or after step (a... | 06/05/2001 |
| 6194221 | Hybrid one-step immunochromatographic device and method of use This invention relates to a lateral flow immunochromatographic assay device with an increased range of sensitivity without an increase in the clearance time or the occurrence of false positive results. The indicator reagent for the analyte is located in b... | 02/27/2001 |
| 6165740 | Method and device for flow-cytometric microorganism analysis To reduce the effects of the contaminants in the measurement of microorganisms and the reduction of the time necessary for the measurement. Measurement is performed of the microorganism prior to and following culture, and the difference between the two is... | 12/26/2000 |
| 6159724 | Process for preparing culture mediums for culturing yeasts and lactic acid bacteria A culture medium which is completely free of chemical additives and which can be used for the individual culture of yeast and of lactic acid bacteria or for the coculture of yeasts and lactic acid bacteria is prepared. The preparation of the medium is car... | 12/12/2000 |
| 6120775 | Streptococcus equi vaccine The present invention relates to a method of systemically administering a vaccine comprising live attenuated bacteria of the species Streptococcus equi in order to protect against Streptococcus equi infection.... | 09/19/2000 |
| 6114161 | Antitumor preparations A new bacteria species within the genus Streptococcus is disclosed, designated as Streptococcus sp PT DSM 8747. From this bacteria species a lipoteichoic acid LTA can be isolated which has a lipid anchor, galacto-furanosyl-beta-1-3-glycerol with different... | 09/05/2000 |
| 6110685 | infB The invention provides infB polypeptides and polynucleotides encoding in polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing infB polypeptides to screen for antibacterial compounds.... | 08/29/2000 |
| 6090596 | Method and means for the production of hyaluronic acid Supercapsulated strains of group A and C streptococci are provided. The strains are used in the production of hyaluronic acid with a molecular weight exceeding 6 million.... | 07/18/2000 |
| 5985654 | Recombinant poxvirus and streptococcal M protein vaccine Viruses of the family poxviridae such as vaccinia or fowlpox viruses are modified to contain a gene which expresses a protein corresponding to the conserved exposed region of the M6 protein. The modified products are useful as vaccines against streptococc... | 11/16/1999 |
| 5965400 | DNA encoding a truncated pneumogoccal surface protein (PspA) A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membran... | 10/12/1999 |
| 5932455 | Method for preparing pure lactic acid The invention relates to a method for preparing pure lactic acid or a salt thereof by fermentation. The preparation process comprises bioreactor refreshing cycle and a lactic acid production cycle, wherein during the production cycle a solution comprising... | 08/03/1999 |
| 5928895 | IgA Fc binding protein The invention provides IgA Fc binding protein polypeptides and DNA (RNA) encoding IgA Fc binding protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing IgA Fc binding protein pol... | 07/27/1999 |
| 5895648 | Composition for feed use comprising lyophilized live lactic bacteria The invention relates to a composition for feed use containing a mixture of lyophilized live bacteria comprising at least two species of bacteria selected from Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum and Bifidobacterium bif... | 04/20/1999 |
| 5888760 | Universal test systems and methods of use thereof for identifying multiple families of microorganisms The present invention relates to a universal test systems and methods of use thereof for identifying a microorganism among at least two groups of widely divergent microorganisms. The universal test system comprises a predetermined combination of non-redun... | 03/30/1999 |
| 5871951 | Compositions and methods for treatment of infection caused by Haemophilus influenzae and Streptococcus pneumoniae The invention relates to a method of identifying a compound capable of disrupting the addition of choline onto a bacterial cell surface component comprising incubating a sample of bacteria in a solution containing choline in the presence or absence of a t... | 02/16/1999 |
| 5871943 | Immunoassay comprising a truncated pneumococcal surface protein A (PspA) A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membran... | 02/16/1999 |
| 5843765 | Streptomyces microorganism useful for the preparation of (R)-baclofen from the racemic mixture The invention disclosed relates to the biological production of substantially isomerically pure (R)-baclofen and structurally related compounds, from the racemic mixture of (R)- and (S)-isomers thereof, and to the isolation of a Streptomyces microorganism... | 12/01/1998 |
| 5834278 | Bacterial peptide methionine sulfoxide reductase an adhesion-associated protein, and antibiotic therapies based thereon The present invention relates to the identification of a bacterial adhesion associated protein, and the gene encoding such protein. More particularly, the invention relates to a pneumococcal peptide methionine sulfoxide reductase involved in bacterial adh... | 11/10/1998 |
| 5786197 | lep lep polypeptides and DNA (RNA) encoding such lep and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such lep for the treatment of infection, particularly bacterial infections. A... | 07/28/1998 |
| 5753463 | Structural gene of pneumococcal protein A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membran... | 05/19/1998 |
| 5750363 | Method for determining the antimicrobial agent sensitivity of a nonparaffinophilic microorganism and an associated apparatus A method for determining the sensitivity of at least one nonparaffinophilic microorganism from a specimen obtained from a patient to an antimicrobial agent. The method includes providing at least one receptacle containing an aqueous solution that does not... | 05/12/1998 |
| 5741662 | Direct stain specific binding assays for microorganisms The present invention provides specific binding solid phase assay methods and kits for the detection of the presence or absence of a microorganism by directly staining the microorganism and specifically capturing the stained microorganism on a solid suppo... | 04/21/1998 |
| 5712107 | Substitutes for modified starch and latexes in paper manufacture The present invention provides methods of making paper utilizing glucans, produced by the glucosyltransferase C enzyme of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to the hydroxethyl modif... | 01/27/1998 |
| 5683890 | Bacteriocins from Streptococcus thermophilus The invention relates to two new Streptococcus thermophilus bacteriocins having the amino acid sequences SEQ ID NO: 1 and SEQ ID NO: 2, the signal peptides of these two bacteriocins, the nucleotide sequences encoding these bacteriocins especially an opero... | 11/04/1997 |
| 5665561 | Modulators of pneumococcal adherence to pulmonary and vascular cells and diagnostic and therapeutic applications The present invention relates to compositions and methods for preventing pneumococcal infection. In particular, this invention relates to the identification of the minimum receptor targets of pneumococcal adherence to pulmonary and vascular endothelium, a... | 09/09/1997 |
| 5620865 | Medium for detecting Enterococci in a sample Medium for growing Enterococci so that detection may be obtained within 24 hours.... | 04/15/1997 |
| 5610011 | Virulence-encoding DNA sequences of Strepococcus suis and related products and methods The invention provides DNA sequences which code for polypeptides which are characteristic for the virulence of the pathogenic bacterium Streptococcus suis and parts thereof, and polypeptides and antibodies derived therefrom. The sequences code for a polyp... | 03/11/1997 |