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| Number | Title | Issue Date |
| 8187840 | Microorganism producing inosine and method of producing inosine using the same The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a reco... | 05/29/2012 |
| 8178322 | Method for producing an L-amino acid or a nucleic acid A method is described for producing an L-amino acid or a nucleic acid by culturing a microorganism having an ability to produce the L-amino acid or nucleic acid in a liquid medium in a fermentation tank containing a stirring impeller, and optionally adding seed crys... | 05/15/2012 |
| 8012717 | Method for the production of cladribine A method for producing cladribine (2-chloro-2′ deoxyadenosine) comprising the steps of: a) reaction of 2-deoxyuridine with 2-chloroadenine, in the presence of uridine phosphorylase (UPase) and purine nucleoside phosphorylase (PNPase) in an aqueous reaction medium ... | 09/06/2011 |
| 7776566 | Method for producing purine nucleoside by fermentation A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated represso... | 08/17/2010 |
| 7435560 | Method for producing purine nucleoside by fermentation A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated represso... | 10/14/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7335496 | Method for producing target substance A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modif... | 02/26/2008 |
| 7229797 | Enzymatic synthesis of deoxyribonucleosides The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method. ... | 06/12/2007 |
| 7217558 | Microorganism producing 5'xanthylic acid The invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 producing 5′-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 which is a mutant strain of Corynebacterium amm... | 05/15/2007 |
| 7148042 | Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group... | 12/12/2006 |
| 7141397 | Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group... | 11/28/2006 |
| 7141396 | Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group... | 11/28/2006 |
| 7067261 | Methods and compositions for treatment of central nervous system disorders The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). ... | 06/27/2006 |
| 7038039 | Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase,... | 05/02/2006 |
| 6927026 | Orotidine-5′-phosphate decarboxylase-gene, gene construct containing said gene and the utilization thereof The invention relates to an orotidine-5′-phosphate decarboxylase gene having the sequence of SEQ ID NO: 1 or its homologs, to a gene construct comprising this gene or its homologs, and to its use. The invention additionally relates to vectors or organisms comprisi... | 08/09/2005 |
| 6911341 | Vectors, host cells, and methods for production of uridine phosphorylase and purine nucleoside phosphorylase Strains of genetically modified prokaryotic micro-organisms capable of expressing polypeptides having the enzyme activity of the enzymes uridine posphorylase (UdP) and purine nucleoside phosphorylase (PNP) are described; the strains in question can be used, both in ... | 06/28/2005 |
| 6777208 | Method for producing 2′ -deoxyribonucleoside A 2′-deoxyribonucleoside is produced by culturing a microorganism, which is transformed with a gene encoding a ribonucleotide reductase and in which 2′-deoxyribonucleoside degradation activity is decreased or eliminated by disrupting a gene encoding a purine nuc... | 08/17/2004 |
| 6743910 | Stereoselective synthesis of nucleoside analogues The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of β and α anomers represented by the following formula A or formula B: wherein R is selected from the... | 06/01/2004 |
| 6649753 | Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The proce... | 11/18/2003 |
| 6635615 | Stable salts of S-adenosyl-l-methionine Stable salts of S-adenosyl-1-methionine with polycations such as chitosan are described. The salts according to the invention are very stable and are valuable for use as active constituents in pharmaceutical compositions.... | 10/21/2003 |
| 6620596 | Method of preparing a guanosine-group compound A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected fro... | 09/16/2003 |
| 6541625 | Stereoselective synthesis of nucleoside analogues The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of ଲ and anomers represented by the following formula A or formula B: ##STR1## wherein R is selected from the group consistin... | 04/01/2003 |
| 6506896 | Use of a pentopyranosyl nucleoside for producing an electronic component, and conjugates of said pentopyranosyl nucleoside The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) ##STR1## their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.... | 01/14/2003 |
| 6306647 | Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides A process for converting uridines to 2',3'-dideoxy-2',3'-didehydrouridines by reacting acetic anhydride with a 2',3'-0-alkoxymethylideneuridine intermediate.... | 10/23/2001 |
| 6291215 | Inhibitory effects on synthetic and natural colorants on carcinogenes A method of reducing the percentage of Epstein-Barr virus genome-carrying cells which exhibit Epstein-Barr virus early antigen induction, where the Epstein-Barr virus genome-carrying cells have been cultivated in the presence of at least one tumor-promoti... | 09/18/2001 |
| 6197552 | Process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine A process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine. These compounds may be used as materials for pharmaceuticals, such as antiviral agents and the like, and particularly as starting materials for antisense oligonucleotides.... | 03/06/2001 |
| 6172209 | Aminooxy-modified oligonucleotides and methods for making same Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups (such as 2'-aminooxy groups) for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl n... | 01/09/2001 |
| 6087132 | Multi-functional enzymes including derivable 2'3'-dideoxyribofuranoside triprosphates The invention relates to a multifunctional nucleoside didesoxyribosyl or nucleoside deoxyribosyl transferase which has one or more of the following additional activities (desoxy) nucleoside kinase, nucleoside reductase desaminase, or DNA polymerase activi... | 07/11/2000 |
| 6040158 | Process for preparing sugar nucleotide A process for preparing a sugar nucleotide from a nucleotide by using a yeast cell, characterized in that both a nucleoside diphosphate-sugar pyrophosphorylase and a sugar 1-phosphate are present in the reaction system. According to this process, various ... | 03/21/2000 |
| 6017736 | Method of preparing purine nucleoside compound The present invention provides a method of preparing stably and at a high yield a purine nucleoside compound by utilizing an exchange reaction of a nucleic acid base which is carried out in the presence of an enzyme, and also provides a microorganism capa... | 01/25/2000 |
| 5948648 | Nucleotide compounds including a rigid linker A nucleoside/tide compound having the structure NUC--L--S--LB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a member of a linkage pair or a label. NUC is attached to L through ... | 09/07/1999 |
| 5851494 | Solid phase synthesis reaction vessel and method of using the same A solid phase synthesis reaction vessel includes a vessel with a first inlet, a second inlet, and an outlet. A first stopcock is disposed within the first inlet and a second stopcock is disposed within the outlet. Solid phase material is prevented from es... | 12/22/1998 |
| 5821090 | Riboflavin-biosynthesis in fungi The present invention relates to the genes for riboflavin biosynthesis in the fungus Ashbya gossypii and to genetic engineering processes for preparing riboflavin using these genes and gene products.... | 10/13/1998 |
| 5770716 | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same Substituted propargylethoxyamido nucleosides are disclosed having the structure ##STR1## wherein X is selected from the group consisting of amino alkanoic acid, alkylamino benzoic acid, -amino acid, and 4-amino-2-butynoic acid. R1 | 06/23/1998 |
| 5714351 | Cyclopentenes The individual enantiomers of the compounds (Ia), (Ib), (IIa) or (IIb), optionally substituted by non-interfering substituent(s). The novel enantiomers can be obtained by biotransformation. The (Ia) or (IIa) compounds can be used for the synthesis of chir... | 02/03/1998 |
| 5700666 | Process for the production of arabinonucleotides A process for the production of arabinonucleotides of general formula I ##STR1## in which X represents a hydrogen atom or a fluorine atom, is described, which is characterized in that an arabinonucleoside of general formula II ##STR2## in which ... | 12/23/1997 |
| 5563049 | 2',3'-dideoxy purine nucleosides and process for the preparation thereof 2',3'-Dideoxy purine nucleosides represented by following general formulae [I] and/or [II] ##STR1## (wherein X and Y indicate nitrogen atoms or carbon atoms and R1, R2, R3, R4 and R5 indicate eac... | 10/08/1996 |
| 5506122 | Process for producing nucleosides The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby formin... | 04/09/1996 |
| 5391550 | Compositions of matter and methods for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair Disclosed are methods and compositions of matter for increasing the intracellular synthesis of ATP. The compositions comprise amino acids, metabolites, electrolyte and/or a pentose sugar. When applied to wounds, the invention increases the rate of wound r... | 02/21/1995 |
| 5384251 | Process for producing nucleosides The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby formin... | 01/24/1995 |
