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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 6960447 | Isolation of membrane bound ligand-specific complexes A method to recover receptors without removing microenvironmental components associated with them is described. The membranes containing the receptors are first associated with ligand-coupled solid supports to achieve association of the membranes through a receptor/... | 11/01/2005 |
| 6942169 | Micromachined lysing device and method for performing cell lysis A method and device for performing lysing on a cell-containing fluid, in which the fluid flows through a vibrating micromachined tube to physically rupture the cell walls (mechanical lysis), and/or to mix, agitate or homogenize the fluid during chemical lysis, and/o... | 09/13/2005 |
| 6818409 | Isolation and purification of Clostridium botulinum toxins A method for separating and purifying HA-positive progenitor toxin(s) (LL and/or L toxins) and HA-negative progenitor toxin (M toxin) from a Clostridium botulinum strain is provided. The method comprises applying a liquid containing both the HA-positive proge... | 11/16/2004 |
| 6812023 | Methods of producing membrane vesicles The present invention relates to methods of preparing biological material, for use in various experimental, diagnostic or therapeutic uses, including immunotherapy treatment or prophylaxy of tumors. More particularly, the present invention relates to methods of prep... | 11/02/2004 |
| 6541015 | Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradabl... | 04/01/2003 |
| 6340597 | Electrochemical biosensors and process for their preparation The present invention concerns new electrochemical biosensors for the determination of analytes concentration in sample solutions or suspensions, based on composite transducers containing an electro-conducting material, in the form of powder or grains, a ... | 01/22/2002 |
| 6281008 | Nucleic acid extraction apparatus This invention provides an apparatus for extracting nucleic acids from nucleic acid-containing samples. The nucleic acid extraction apparatus of the invention comprises (1) a group of extraction vessels each comprising a reactor tube in which a sample, a ... | 08/28/2001 |
| 6274370 | Yeast debris products The present invention provides a coloring agent comprising glucan-containing yeast cell ghosts which comprise a proportion of substantially intact yeast cell walls and at least one color source. The color source is selected to give the desired color in th... | 08/14/2001 |
| 6114131 | Methods for the detection of antibodies to ornithobacterium rhinotracheale The present invention relates to a novel bacterial respiratory poultry disease and the identification of the causative agent. A vaccine derived from this agent was effective in preventing the disease in chickens challenged with the virulent field strains.... | 09/05/2000 |
| 6103508 | Method for removing fumarase activity, microorganisms obtainable by the method, and production of optically active aminopolycarboxylic acids using the microorganisms This invention relates to a method for removing fumarase activity from a microorganism or processed product thereof having ethylenediamine-N,N'-disuccinic acid ethylenediamine lyase activity, which includes treating the microorganism or processed product ... | 08/15/2000 |
| 6100079 | Method for treating biopolymers, microorganisms or materials by using more than one type of magnetic particles Method and apparatus are described for purifying and separating biopolymers from a homogenized biological milieu using a pipette tip. The biopolymers are complexed with first magnetic particles. A magnet is applied to the pipette tip to attract the biopol... | 08/08/2000 |
| 6100084 | Micro-sonicator for spore lysis A micro-sonicator for spore lysis. Using micromachining technology, the micro-sonicator uses ultrasonic excitation of spores to perform spore and cell lysis. The micro-sonicator comprises a container with a cavity therein for retaining the sample in an ul... | 08/08/2000 |
| 6051552 | Lactobacillus therapies The present invention is directed towards isolated lactobacillus biosurfactants and the process for producing same. The present invention is also directed to methods for preventing urogenital infection in mammals using the isolated lactobacillus biosurfac... | 04/18/2000 |
| 5968767 | Methods for in vitro protein synthesis A method is provided for in vitro protein synthesis in a bacterial extract wherein the reaction mixture comprises a reducing agent and dissolved oxygen (DO2) wherein the DO2 concentration is regulated such that complete oxidation of ... | 10/19/1999 |
| 5958706 | Fine magnetic particles containing useful proteins bound thereto, process for producing the same, and use thereof This invention provides a useful protein-bound magnetic particle which includes a magnetic particle produced in the cell of a magnetic bacterium, and a hybrid protein bound to an organic membrane covering the magnetic particle, and of which the hybrid pro... | 09/28/1999 |
| 5952222 | Functional enucleation of bovine oocytes A method of preparing a recipient oocyte from a target zona-intact or zona-free oocyte by centrifuging the oocyte against a density gradient material to force the chromosomal material to pass through the cytoplasmic membrane.... | 09/14/1999 |
| 5914127 | Isolation and uses of caveolae Methods of isolating and purifying caveolae, microdomains of GPI-anchored proteins, and membranes consisting essentially of caveolae associated with microdomains of GPI-anchored proteins from endothelial cell membranes are disclosed. The methods comprise ... | 06/22/1999 |
| 5840878 | Vehicle for delivery of particles to a sample The present invention relates to a vehicle for delivery of particles to a sample of cells. The vehicle includes a barrier to retain the particles, which barrier is a dissolvable material. Once released into the sample, the particles are useful in methods ... | 11/24/1998 |
| 5830659 | Active microtubule-based separations by kinesins A method and system for separating a selected molecule from a heterogeneous mixture of molecules in aqueous solution are described. The method comprises (a) providing a separation device comprising a loading reservoir and a receiving reservoir coupled by ... | 11/03/1998 |
| 5811239 | Method for single base-pair DNA sequence variation detection The present invention describes a method for the detection of single base-pair DNA sequence variation in DNA samples isolated from cells with limited ploidy (1~ 3N). The method can detect variation essentially anywhere in the genome. The method... | 09/22/1998 |
| 5780424 | Purified ribosomal fractions separated from the nonphotosynthetic filamentous bacteria beggiatoales Variously pure ribosomal fractions separated from at least one nonphotosynthetic filamentous bacterium are well suited for formulation into a variety of cosmetic/pharmaceutical compositions, for example for the immunostimulation of the immune system of th... | 07/14/1998 |
| 5747663 | Process for the depletion or removal of endotoxins A process is disclosed for reducing or removing endotoxins from compositions containing therapeutic active substances extracted from natural sources by genetic engineering and/or biotechnology. For that purpose, the compositions are treated with chromatog... | 05/05/1998 |
| 5691174 | Production of plastics materials from microorganisms A plastic is recovered from microorganisms containing it by chemically solubilising non plastic material with an oxidising agent in the presence of a chelating agent.... | 11/25/1997 |
| 5670310 | Methods and compositions for differential diagnosis of acute and chronic hepatitis c virus infection The present invention provides antigenic peptides which bind anti-HCV antibodies for the differential diagnosis of acute and chronic HCV infection. The invention further provides a method of differentiating acute and chronic hepatitis C virus infection in... | 09/23/1997 |
| 5665582 | Isolation of biological materials A method for the isolation and sorting of biological materials has been developed. Biological material includes chromosomes, segments of chromosomes, cell organelles, or other minute cellular components. The biological material is separated from the cellu... | 09/09/1997 |
| 5652096 | Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes Hybridization method for discriminating between complementarity and partial complementarity of DNA base sequences. Kinetic covalent entrapment of PCR-amplified target DNA is achieved through the use of crosslinkable probes. A crosslinking site is introduc... | 07/29/1997 |
| 5599664 | Method for characterizing polymer molecules or the like A method for observing and determining the size of individual particles and for determining the weight distribution of a sample containing particles of varying size, which involves placing a deformable or nondeformable particle in a medium, subjecting the... | 02/04/1997 |
| 5545557 | Water insoluble coloring agent The present invention provides a water insoluble coloring agent containing glucan-containing yeast cell ghosts which contain a proportion of intact yeast cell walls and at least one water soluble color source. The color source is selected to give the desi... | 08/13/1996 |
| 5482834 | Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells Nucleic acid components in a biological sample are detected and/or quantified utilizing a process wherein the sample is first solubilized with a chaotropic salt solution. In a preferred embodiment, cells and nucleic acid components therein are solubilized... | 01/09/1996 |
| 5482833 | Test to determine predisposition or susceptibility to DNA associated diseases Cellular DNA repair enzyme activity has been found to be an indicator of susceptibility or predisposition of an individual to DNA associated diseases. The activity of the enzyme adenosine diphosphate ribosyl transferase (ADPRT) has been found to be a good... | 01/09/1996 |
| 5474911 | Promotion of high specificity molecular assembly This invention relates to an improvement in promoting the rate of association for high specificity binding pairs used in a variety of industrial, research and medical applications. These pairs include enzyme/substrate, complementary polynucleotide and ant... | 12/12/1995 |
| 5447841 | Methods for chromosome-specific staining Methods and compositions for chromosome-specific staining are provided. Compositions comprise heterogenous mixtures of labeled nucleic acid fragments having substantially complementary base sequences to unique sequence regions of the chromosomal DNA for w... | 09/05/1995 |
| 5447864 | Capture method for cell nucei using a DNA mesh A method of separating cell nuclei from cells comprises: treating a fluid containing whole cells so as to selectively lyse the cytoplasmic membrane together with a small proportion of the nuclear membranes but leaving a large proportion of the cell nuclei... | 09/05/1995 |
| 5443981 | Acremonium typhinum ATCC 74228 which exhibits endoproteolytic activity A crude membrane fraction of leaf sheath tissue of a grass endophytically infected by A. typhinum is produced. The extract exhibits endoproteolytic activity in the presence of detergent or after methanol precipitation. This activity is optimal at 35°-40Â... | 08/22/1995 |
| 5418137 | Flea membrane binding site proteins as screening tools The cellular binding proteins present in membranes of fleas, especially those which are present in the digestive tract, are useful as screening tools for systemic anti-flea reagents and in the design of vaccine formulations. Particularly useful is the &#x... | 05/23/1995 |
| 5362624 | Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inne... | 11/08/1994 |
| 5350673 | Detection of a unique Chlamydia strain associated with acute respiratory disease Methods for detecting a unique strain of Chlamydia associated with acute respiratory disease are disclosed. These methods utilize monoclonal antibody directed against an antigenic determinant of the TWAR organism, or DNA probes capable of specifically hyb... | 09/27/1994 |
| 5281518 | Detection of a unique chlamydia strain associated with acute respiratory disease Methods for detecting a unique strain of Chlamydia associated with acute respiratory disease are disclosed. These methods utilize monoclonal antibody directed against an antigenic determinant of the TWAR organism, or DNA probes capable of specifically hyb... | 01/25/1994 |
| 5273877 | Non-histological cell type determination Disclosed are non-histological methods for determining the presence in a sample of a preselected cell type such as a malignant or genetically defective cell, or cell nucleus debris from such cells. The methods involve determination of an intranuclear matr... | 12/28/1993 |
| 5240853 | Apparatus and method for continuously removing oxygen from fluid streams using bacterial membranes The present invention is directed to a continuous flow method for removing oxygen from a fluid stream. The method comprises the steps of providing a fluid stream containing oxygen, causing the fluid stream to come in contact directly or indirectly, with a... | 08/31/1993 |
