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| Number | Title | Issue Date |
| 7435569 | Method of forming a molded protein matrix for use in a sensor A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical ... | 10/14/2008 |
| 7429630 | Redox polymers for use in electrochemical-based sensors A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer ar... | 09/30/2008 |
| 7398161 | Sampling method and sampling device, and logD measuring method and logD measuring system A sampling method sampling a lower-layer liquid from a liquid body comprised of two layers of liquids, an upper-layer liquid (octanol) and the lower-layer liquid (buffer solution), without mixing the layers. An extracting device is provided with a tubular apical end... | 07/08/2008 |
| 7364873 | Method for manufacture of lactate biosensing strip We provide a lactate biosensing strip comprising a working electrode and a reference electrode, the two electrodes being deposited on an electrically insulated base support, the working electrode being formed by immobilizing lactate oxidase and an electron mediator ... | 04/29/2008 |
| 7332297 | Enzymatic polymerization The invention relates to a novel method for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction mixture for a time and under conditions sufficient for the monomer to... | 02/19/2008 |
| 7319018 | Lactate biosensing strip with two electrodes We provide a lactate biosensing strip comprising a working electrode and a reference electrode, the two electrodes being deposited on an electrically insulated base support, the working electrode being formed by immobilizing lactate oxidase and an electron mediator ... | 01/15/2008 |
| 7309582 | Polymer-template complex produced by enzymatic polymerization The invention relates to a novel method for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction mixture for a time and under conditions sufficient for the monomer to... | 12/18/2007 |
| 7250288 | Electrode compositions and configurations for electrochemical bioreactor systems Electrodes and configurations for electrochemical bioreactor systems that can use electrical energy as a source of reducing power in fermentation or enzymatic reactions and that can use electron mediators and a biocatalyst, such as cells or enzymes, to produce elect... | 07/31/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7192766 | Sensor containing molded solidified protein A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical ... | 03/20/2007 |
| 7115362 | Electrochemical test device and related methods An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The w... | 10/03/2006 |
| 7109271 | Redox polymers for use in electrochemical-based sensors A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer ar... | 09/19/2006 |
| 7090996 | Process for examining membrane enclosed biocompartments A process for the examination of biocompartments (1), having a micro-flow chamber (2) which contains a biocompartment (1) which is continually or intermittently subjected to the through-flow of a culture medium. In a culture medium zone proximal... | 08/15/2006 |
| 7018848 | Electrochemical test device and related methods An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The w... | 03/28/2006 |
| 6960466 | Composite membrane containing a cross-linked enzyme matrix for a biosensor An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors. ... | 11/01/2005 |
| 6933143 | Automated enzyme-linked immunosorbent assay device with ONP-GP An electronic controller, such as a programmed microcontroller, controls a series of pumps to automatically sequence the pumping of the individual fluids required by the ELISA procedure into a cell (or cells) necessary to produce a reporter, including the addition o... | 08/23/2005 |
| 6927033 | Polymer composition for forming surface of biosensor A polymer composition is provided, which contains a polymer or copolymer having a mercapto group at one end and functional group or ligand at the other end and also having a polyethylene glycol segment. Such a composition can form a biosensor surface of reduced non-... | 08/09/2005 |
| 6897035 | Biosensor The present invention relates to a biosensor for the detection and/or the determination of freshness biomarkers, such as biogenic amines (preferably histamine) in food and beverage, comprising an electrode and a mono-enzyme system, such as an amine oxidase, or a bi-... | 05/24/2005 |
| 6893814 | Influenza sensor A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional ... | 05/17/2005 |
| 6881551 | Subcutaneous glucose electrode A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in th... | 04/19/2005 |
| 6861232 | Creatinine biosensor The present invention generally relates to a method for producing biosensors and a biosensor for determination of creatinine. The biosensor comprises at least two enzymes, for the amperometric determination of enzymatically degradable substances in biological liquid... | 03/01/2005 |
| 6858403 | Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide Hydrogels containing catalase co-immobilized with an analyte-sensitive enzyme such as glucose oxidase are disclosed. The hydrogels may be pH-sensitive, and preferably are thin and lightly crosslinked. The catalase is present in concentrations ranging generally from ... | 02/22/2005 |
| 6855556 | Binding protein as biosensors The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived there from, and their use as analyte biosensor both in vitro and in vivo. ... | 02/15/2005 |
| 6846654 | Catalytic antibodies as chemical sensors A system for detecting physical or chemical changes in an environment is disclosed. The system comprises means for conducting a chemical reaction; an active biological molecule whose physiological function is noncatalytic which is capable of catalyzing a chemical re... | 01/25/2005 |
| 6846639 | Method for detecting pathogens attached to specific antibodies The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode att... | 01/25/2005 |
| 6841379 | Conductive microplate A conductive microplate device for the detection of target biomolecules in a sample is described. The microplate comprises an assembly of a porous substrate and a conductive layer, wherein the assembly is sealed into bottom of at least some wells of the microplate. ... | 01/11/2005 |
| 6835552 | Impedance measurements for detecting pathogens attached to antibodies The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode att... | 12/28/2004 |
| 6814845 | Method for depositing an enzyme on an electrically conductive substrate Improved biosensors are provided having excellent selectivity and stability properties, together with methods of preparing the biosensors. A preferred biosensor includes an electrode (12) having enzyme (16) deposited thereon together with a layer of el... | 11/09/2004 |
| 6770179 | Biosensors comprising a covalently attached monomolecular biological conjugate layer and a transducing device The present invention relates to a biosensor which comprises a covalently attached monomolecular biological conjugate layer and a transducing system, wherein the biological conjugate layer has the following structural formula I: —R—X—P I | 08/03/2004 |
| 6762062 | Method of determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipopr... | 07/13/2004 |
| 6709856 | Liquid sample measuring device containing electrode sensor with enzyme layer A device and method are provided using a sensor containing an electrode with an enzyme layer to determine a component in a liquid sample. Inlet and outlet channels feed liquid sample to and from the sensor surface. The inlet channel is placed an angle of preferably ... | 03/23/2004 |
| 6692696 | Biosensor Apparatus comprising G-protein coupled receptor (GPCR) for detecting ligands or substances in liquid or vapor media. The GPCR is based on in a cell or in a synthetic membrane or polymer system, and combined with means for obtaining a sample of a liquid or... | 02/17/2004 |
| 6653091 | Method and device for predicting physiological values The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. ... | 11/25/2003 |
| 6638716 | Rapid amperometric verification of PCR amplification of DNA Rapid electrochemical verification of the amplification of DNA by a polymerase chain reaction in a small sample of the PCR product.... | 10/28/2003 |
| 6627396 | Influenza sensor A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a tri... | 09/30/2003 |
| 6582583 | Amperometric biomimetic enzyme sensors based on modified cyclodextrin as electrocatalysts The present invention provides a novel biosensor for the detection of chemicals of interest. The novel biosensor of the present invention comprises an electrode having a catalytically active cyclodextrin attached thereto. The present invention will be use... | 06/24/2003 |
| 6579690 | Blood analyte monitoring through subcutaneous measurement One embodiment of the invention is a method for obtaining an estimate of an analyte concentration in a first fluid. First, measurements of an analyte concentration in a second fluid are obtained using a sensing device. An analyte concentration estimate in... | 06/17/2003 |
| 6579673 | Patterned deposition of antibody binding protein for optical diffraction-based biosensors The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of an antibody-binding ... | 06/17/2003 |
| 6576460 | Filtration-detection device and method of use The present invention relates to a filtration-detection device for detecting or quantifying an analyte in a test sample including a filtration device having a first binding material immobilized thereto, wherein the first binding material is capable of bin... | 06/10/2003 |
| 6573109 | Surface amplifier The present invention relates to a membrane for use in detecting the presence of an analyte. The membrane comprises an array of closely packed self-assembling amphiphilic molecules and a plurality of first and second receptor molecules, the first receptor... | 06/03/2003 |
