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| Number | Title | Issue Date |
| 7371830 | Method for separating biological material from a fluid using magnetic particles Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A... | 05/13/2008 |
| 7332126 | Integrated microfluidic disc Disclosed is a method for performing the steps of nucleic acid template purification, thermocycling reaction and purification of the products of the thermocycling reaction characterized in that the steps take place sequentially in a microfluidic disc. Also disclosed... | 02/19/2008 |
| 7115719 | Formulations and methods for denaturing proteins Reagents, methods and kits for denaturation of protein are provided. ... | 10/03/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7105339 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/12/2006 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7063976 | Process for preparing beta-fructofuranosidase enzyme and a process for producing fructooligosaccharides A process for preparing beta-fructofuranosidase enzyme and a process for producing fructooligosaccharides, in which the preparation of the enzyme is obtained by cultivating the fungus Aspergillus niger, either wild or mutated, in a preferably semi-solid cultu... | 06/20/2006 |
| 6982158 | Extraction and purification of phosphodiesterase 1 A process for purifying a phosphodiesterase 1 (PDE-1) from a cell including heating an extract of a cell formed from a solution including at least one divalent cation, to increase the specific activity of PDE-1 in the extract. ... | 01/03/2006 |
| 6908602 | Hydrocarbon conversion process Method for producing hydrogen and a hydroprocessed product from a hydrocarbonaceous feedstock by subjecting it to a catalytic hydrocracking treatment using hydrogen which has been at least partly produced from hydrocracked feedstock and subjecting at least pan of th... | 06/21/2005 |
| 6884597 | Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deace... | 04/26/2005 |
| 6884395 | Integrated microfluidic disc Disclosed is a method for performing the steps of nucleic acid template purification, a thermocycling reaction and purification of the products of the thermocycling reaction characterised in that the steps take place sequentially in a microfluidic disc. Also disclos... | 04/26/2005 |
| 6870047 | Magnetic pigment Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A... | 03/22/2005 |
| 6830655 | Method of modifying a xylan-containing carbohydrate substrate having hexenuronic acid groups attached to the xylan The present invention concerns a method for enzymatic treatment of lignocellulosic materials which contain xylan-polymers, such as cellulose kraft pulps. According to a method of the present kind, at least a part of the hexenuronic acid groups present in the materia... | 12/14/2004 |
| 6825027 | Method of production of purified hepatitis a virus particles and vaccine preparation The present invention provides methods of purification of Hepatitis A Virus from the supernatant of an infected cell culture and production of a preparation of purified HAV antigen. The present invention is also directed to an HAV vaccine composition comprising a pr... | 11/30/2004 |
| 6783929 | Biological sample component purification and differential display Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compat... | 08/31/2004 |
| 6762062 | Method of determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipopr... | 07/13/2004 |
| 6706486 | Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins (antibodies, in particular of the IgG class and primarily becoming bou... | 03/16/2004 |
| 6649354 | Catalytically generated mass labels The present invention involves a method for assaying a substance. The method of the present invention comprises contacting the substance with an assay agent comprising a catalytic agent to associate the substance with the catalytic agent, contacting the r... | 11/18/2003 |
| 6635420 | Purification of substances from a biological sample The invention concerns a method for the purification of a target substance from a biological sample by immobilizing the target substance on a solid phase by means of a high affinity binding pair and subsequently eluting it by adding a partner of the bindi... | 10/21/2003 |
| 6576460 | Filtration-detection device and method of use The present invention relates to a filtration-detection device for detecting or quantifying an analyte in a test sample including a filtration device having a first binding material immobilized thereto, wherein the first binding material is capable of bin... | 06/10/2003 |
| 6562605 | Extraction of water soluble biomaterials from fluids using a carbon dioxide/surfactant mixture A method is provided for the extraction of water soluble biomaterials such as enzymes or proteins into carbon dioxide utilizing certain carbon dioxide soluble surfactants. The extraction can be performed on an aqueous solution, a fermentation broth or a f... | 05/13/2003 |
| 6555391 | Methods of conditioning an affinity resin after storage This invention relates methods for conditioning affinity chromatography resins to decrease leaching of the ligand during purification. The methods involve incubating the resin in a buffered solution of a hydroxyalkylamine compound (e.g., ethanolamine) pri... | 04/29/2003 |
| 6403350 | Method for rapidly obtaining enzyme crystals with desirable morphologies The present invention provides a crystallization process wherein a starting temperature is selected such that a desirable crystal morphology (e.g., square) is obtained. A temperature shift is then introduced, providing that the shift is not enough to indu... | 06/11/2002 |
| 6391654 | Separation and detection of spermatozoa A kit for testing male fertility comprises a vessel, a base unit, a liquid supply containing liquid and two filters. The first filter is a sample separation filter which forms a hindrance to transmission of spermatozoa. The second filter of the kit is a s... | 05/21/2002 |
| 6387377 | Acellular antibordetella vaccine The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B. Tertussis, B. parapertussis or B. bron... | 05/14/2002 |
| 6383819 | Method for determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low den... | 05/07/2002 |
| 6379599 | Process for the preparation of molecularly imprinted polymers useful for separation of enzymes The invention relates to a process for the preparation of molecularly imprinted polymers useful for separation of enzymes, which comprises the steps of reacting a complex of enzyme and affinity monomer, a comonomer and a crosslinker, with a polymerization... | 04/30/2002 |
| 6379915 | Diagnostic compositions and devices utilizing same A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinon... | 04/30/2002 |
| 6352852 | Method for the purification of human platelet heparanase A method for the purification of human platelet heparanase using chromatographic techniques is described. The method comprises detergent-aided solubilization of a heparanase-containing fraction followed by purification of the heparanase therefrom by conca... | 03/05/2002 |
| 6316695 | Isopentenyl diphosphate isomerase from Hevea brasiliensis and rubber producing method using the same The present invention cloned a cDNA clone encoding isopentenyl diphosphate (hereafter "IPP") isomerase (EC 5.3.3.2) from a cDNA library of Hevea brasiliensis latex. The clone has a continuous open reading frame encoding a peptide of 234 amino acids with a... | 11/13/2001 |
| 6306590 | Microfluidic matrix localization apparatus and methods Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided.... | 10/23/2001 |
| 6303326 | Insect salivary enzyme triggers systemic resistance The present invention includes the characterization of the major salivary protein or enzyme of the corn earworm Helicoverpa zea for triggering resistance to bacterial blight and frogeye leafspot in soybeans and for triggering resistance to insects in toma... | 10/16/2001 |
| 6255477 | Particles having a magnetic core and outer glass layer for separating biological material Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing th... | 07/03/2001 |
| 6255468 | MPROT12 polynucleotides and methods thereof MPROT12 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MPROT12 polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 07/03/2001 |
| 6251691 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces rel... | 06/26/2001 |
| 6251623 | Quick assay method for the activity of a plant-derived, asparagine residue-specific endoprotease A quick assay method for the activity of a plant-derived, asparagine residue-specific endoprotease is disclosed which comprises measuring fluorescence generated by a fluorescence quenching substrate split by an asparagine residue-specific endoprotease. Th... | 06/26/2001 |
| 6242207 | Diagnostic compositions and devices utilizing same A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a pero... | 06/05/2001 |
| 6214975 | Method for evaluating target protein quality from fermenter A chemiluminescence-based gel assay may be used as an indicator of fermenter health. The assay is performed using a sample of fermentation medium essentially directly from the fermenter (with no need for complicated purification of the sample before perfo... | 04/10/2001 |
| 6200791 | Method of purifying thrombin-like protease enzymes obtained from snake venom A process for purifying thrombin-like proteases from snake venoms is described, which consists in freeing the proteases from impurities in three chromatographic steps: a) affinity or anion exchange, b) adsorption onto a glass matrix at alkaline pH values,... | 03/13/2001 |
| 6156555 | Method of preparing an enzyme participating in C-terminal amidation A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal -hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of ... | 12/05/2000 |
