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| Number | Title | Issue Date |
| 7198941 | Porous vessel bioreactor The present invention provides a porous vessel bioreactor apparatus for use in reaction with immobilized enzymes and/or microbial cells, said apparatus consisting of a vertically elongated reaction vessel having at least one liquid reactant inlet; at least one produ... | 04/03/2007 |
| 7081361 | Biomass generator A biomass generator useful for continuously growing and withdrawing bacteria to be used in a desired beneficial application, the generator having a bacteria growth chamber; water and nutrient inlet ports; upper and lower outlet ports; a recirculating pump withdrawin... | 07/25/2006 |
| 6962794 | Application of glucose transport mutants for production of aromatic pathway compounds This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts−/glucose+. Such host cells... | 11/08/2005 |
| 6723555 | Multi-sample fermentor and method of using same A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an... | 04/20/2004 |
| 6686194 | Method and device for selecting accelerated proliferation of living cells in suspension The present invention relates to a method and a device for selecting accelerated proliferation of living cells in suspension. The culture apparatus (2) of the present invention enables cells to proliferate in suspension over unlimited periods of time. Nat... | 02/03/2004 |
| 6635441 | Multi-sample fermentor and method of using same A fermentation apparatus is constructed to produce a known and repeatable amount of unpoisoned fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation appa... | 10/21/2003 |
| 6620614 | Solid-state fermenter and method for solid-state fermentation The invention concerns a solid state fermenter in particular for large volumes as well as a procedure for solid state fermentation. The task of the present invention was the development of a solid state fermenter for large volumes and of a procedure for solid ... | 09/16/2003 |
| 6562615 | Apparatus for the preparation of chlortetracycline-containing animal feed compositions The present invention provides improved chlortetracycline-containing animal feed compositions and processes and apparatuses for their preparation. In certain embodiments, raw fermentation broth comprising chlortetracycline is divided into two portions. Th... | 05/13/2003 |
| 6492135 | U-shape and/or nozzle u-loop fermentor and method of carrying out a fermentation process A U-shape and/or nozzle-U-loop fermentor has a U-part consisting of an essentially vertical downstream part (2), an essentially vertical upstream part (4), a U-shape bend part (3) which connects the lower ends of the downstream and upstream parts, an inli... | 12/10/2002 |
| 6410265 | Gene encoding a putive efflux protein for solvents/antibiotics in Pseudomonas mendocina This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention f... | 06/25/2002 |
| 6403345 | Obtainment of γ-linolenic acid from protozoa of the genus colpidium The present invention relates to a process for the preparation of γ-linolenic acid (GLA) from Colpidium and its use in foodstuffs, cosmetics and pharmaceuticals. Colpidium can be fermentatively cultured up to a high absolute yield of GLA in an optimized ... | 06/11/2002 |
| 6335191 | Automated system and method for growing bacteria An automated system and method is provided for cultivating bacteria in a fluid medium and thereafter selectively discharging the fluid medium, wherein an initial supply of the selected strain or strains of bacteria is combined with nutrients and water in ... | 01/01/2002 |
| 6268190 | Method of producing arabitol by continuous fermentation A method of producing arabitol by continuous fermentation of at least one sugar by micro-organisms producing arabitol, characterised in that arabitol is produced in a first fermentation area including at least one fermenter in such a manner that some of t... | 07/31/2001 |
| 6214975 | Method for evaluating target protein quality from fermenter A chemiluminescence-based gel assay may be used as an indicator of fermenter health. The assay is performed using a sample of fermentation medium essentially directly from the fermenter (with no need for complicated purification of the sample before perfo... | 04/10/2001 |
| 6200764 | Detection, quantitation and classification of ras proteins in body fluids and tissues This subject of this invention is the detection, quantitation of ras p21 proteins in body fluids, tissues, or cells. Specifically, this invention concerns detecting and quantitating normal and mutated ras p21s from normal subjects, subjects suspected of h... | 03/13/2001 |
| 6136960 | Method for evaluation of the ratio of amounts of biomolecules or their sub-populations in a mixture The present invention is directed to a method of determining the ratio of the concentration or amounts of two or more chemical compounds and/or biopolymers, or of the relative amounts of sub-populations of closely structurally related compounds, in a mult... | 10/24/2000 |
| 6133019 | Centrifugal fermentation process The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered i... | 10/17/2000 |
| 6125736 | Fermenter The present invention relates to a fermenter consisting of a vat provided internally with a diaphragm designed to retain the gas bubbles produced by fermentation and release them when they have reached a large size. The diaphragm consists of a concave sur... | 10/03/2000 |
| 6043022 | Apparatus and method for the generation and use of ferric ions An apparatus and method for the generation and use of ferric ions produced by acidophilic, chemoautotrophic bacteria.... | 03/28/2000 |
| 6008010 | Method and apparatus for holding cells The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled closed environment in which the cells are grown, which are maintained in a desired condition and in ... | 12/28/1999 |
| 6001255 | Process for the production of water-soluble salts of carboxylic and amino acids The invention provides a process for the production and utilization of water-soluble salts selected from the group consisting of water-soluble salts of carboxylic acids and water-soluble salts of amino acids, comprising reacting an aqueous feed solution c... | 12/14/1999 |
| 5981260 | Process for the production of cell mass and/or fermentation products under sterile conditions Process for the production of cell mass and/or fermentation products under sterile conditions, during which the fermentation mixture, at least at times, is recycled and the metabolic products of the cultivated cells, and possibly the cell mass are separat... | 11/09/1999 |
| 5981211 | Maintaining cells for an extended time by entrapment in a contracted matrix Methods of maintaining animal cells for product production, for supporting hepatocyte function and viability to treat a patient suffering from hepatic failure and for preserving tissue-specific function of mammalian cells are carried out with a bioreactor... | 11/09/1999 |
| 5962307 | Apparatus for producing organic acids A continuous process and apparatus for preparing organic acids and their salts from biomass. Biomass flows from a region of fresh biomass and high acid and acid salt concentration to a region of digested biomass and low acid and acid salt concentration in... | 10/05/1999 |
| 5948633 | Method for determining the effect of a chemical compound on microorganisms growing in continous culture A device and process for determining the effect of an antimicrobial agent or other compound on a microorganism growing in continous broth culture. The microorganisms are grown in a vessel of fixed volume (18), which is supplied with a constant inflow of n... | 09/07/1999 |
| 5925563 | Multi-stage column continuous fermentation system A multi-stage column continuous fermentation system for brewing beer and the like. The system comprises several basic interconnected stages or sections including a discharge stage or section, a feed stage, at least one fermentation stage, a top stage, and... | 07/20/1999 |
| 5874263 | Method and apparatus for producing organic acids A continuous process and apparatus for preparing organic acids and their salts from biomass. Biomass flows from a region of fresh biomass and high acid and acid salt concentration to a region of digested biomass and low acid and acid salt concentration in... | 02/23/1999 |
| 5869300 | Method for producing L-glutamic acid by continuous fermentation A method for producing L-glutamic acid, comprising inoculating a microorganism having an ability to produce L-glutamic acid, in a liquid medium containing a carbon source and a nitrogen source, conducting continuous L-glutamic acid fermentation in which b... | 02/09/1999 |
| 5851820 | Unit for the preparation of fermenting gas A unit for the preparation of fermenting gas by fermenting viscous media with mixing paddles that can be moved continuously back and forth and in the same direction in the tank to mix the medium to be fermented. Alternately, the mixing paddles hang from a... | 12/22/1998 |
| 5843763 | Dehalogenation of organohalogen-containing compounds Enzymatic dehalogenation of undesirable nitrogen-free organohalogen compounds is carried out by adding a dehalogenase to an aqueous composition comprising a nitrogen-free organohalogen compound and a nitrogen-containing cationic polymer. The enzymatic deh... | 12/01/1998 |
| 5827701 | Method for the generation and use of ferric ions A process for generating a ferric ion solution. The process includes the steps of establishing in a vessel a population of acidophilic, chemoautotrophic bacteria which oxidize ferrous ions into ferric ions; supplying the bacteria with a feed solution of f... | 10/27/1998 |
| 5821116 | Centrifugal fermentation process The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered i... | 10/13/1998 |
| 5817505 | Particle settler for use in cell culture Disclosed is a device for separating particles from a bulk liquid, such as viable hybridoma cells from antibody-containing liquid medium. The device comprises a plurality of settlement plates, or other surfaces, being inclined to the vertical, and a pump ... | 10/06/1998 |
| 5798253 | Method of culturing micro-organisms under a mutagenic influence An accelerated micro-organism culture method is for decomposing harmful substances. For this purpose, the cultivation, mutagenic treatment and stabilization of the micro-organisms are carried out simultaneously in a mutation fermenter containing a nutrien... | 08/25/1998 |
| 5798254 | Gas driven fermentation method using two oxygen-containing gases A gas driven fermentation method is disclosed wherein a gas, such as air, is passed heterogeneously upwardly through a fermentation broth to agitate and recirculate the broth. Further, the provision of oxygen for fermentation permits the carbon dioxide to... | 08/25/1998 |
| 5795750 | Process for the continuous enzymatic extraction of hydrophobic products and device suitable therefor In a process for the continuous enzyme-catalyticzed enzymatic production of hydrophobic products in an aqueous solution of a reaction mixture, the product is extracted from the product containing reaction mixture by way of a product-permeable microporous ... | 08/18/1998 |
| 5760078 | Process for the fractioning and recovery of valuable compounds from vinasse produced in fermentations A process is provided for the preparation of valuable products from vinasse which contains potassium salts. The process comprises concentrating the vinasse to a dry matter content of 50-80% dry solids and separating the formed crystals in a concentration ... | 06/02/1998 |
| 5753474 | Continuous two stage, dual path anaerobic fermentation of butanol and other organic solvents using two different strains of bacteria The instant invention describes a process for the manufacture of butanol and like volatile organic compounds by fermenting carbohydrates, mainly polysaccharide, with micro-organisms which convert carbohydrates into mainly butyric acid and other acids. The... | 05/19/1998 |
| 5688674 | Continuous fermentation process for the production of metabolities using a moving filter A metabolite, e.g., ethanol, is continuously produced from low cost carbohydrate substrates by a process which comprises pulverizing the carbohydrate substrate; liquefying and saccharifying the pulverized substrate; continuously fermenting the lique-sacch... | 11/18/1997 |
| 5571720 | Integrated cell culture protein purification system for the automated production and purification of proteins An integrated cell culture-protein purification system has been developed for the continuous, automated production of pure cell culture protein products. The instrument comprises a bioreactor subunit having a hollow fiber bioreactor to culture and maintai... | 11/05/1996 |
