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Class 435/811 - INTERFERON


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter in which the antiviral agent interferon is
No. of patents: 153
Last issue date: 09/18/2007


1        
NumberTitleIssue Date
7270974Rapid diagnostic method for detecting bacterial sinusitis
A method and device for rapidly, non-invasively and inexpensively differentiating between allergic rhinitis, upper respiratory tract viral infection and bacterial sinusitis, comprising a support strip upon which is fixed discrete indicators of pH, protein content, n...
09/18/2007
6936694Manufacture and expression of large structural genes
Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products, which products differ from naturally-occurring forms in terms of the...
08/30/2005
6866782Process for the purification of pharmacologically active proteins through cationic exchange chromatography
There is disclosed a process for the purification of pharmacologically active proteins based on the use of the cationic exchange chromatography on a solid matrix carried out at a more basic pH, i.e. higher, in respect of the pH corresponding to the isoelectric point...
03/15/2005
6579688Stabilizing diluent for polypeptides and antigens
Compositions for stabilizing polypeptides or antigens are described. These compositions are useful for stabilizing polypeptides or antigens stored in aqueous formulations. Such formulations can be used for various analytical or other methods....
06/17/2003
6475748Method for differentiating human peripheral blood granulocytes
Disclosed is a method for differentiating human peripheral blood granulocytes which comprises cultivating the granulocytes in the presence of an interferon and acting an immune complex on said granulocytes in the presence of a chemiluminescent substance, ...
11/05/2002
6461605Continuous low-dose cytokine infusion therapy
A method is provided for treating conditions that are susceptible of treatment with a cytokine wherein the undesirable side effects normally associated with cytokine administration are diminished or eliminated. The method comprises continuously administer...
10/08/2002
6300089Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus
The subject invention concerns a novel process for the early detection of insulin dependent diabetes (IDD). The novel process described here enables the detection of the onset of IDD before clinical symptoms appear. The novel process involves the detectio...
10/09/2001
6297015Crohn's disease diagnostic and treatment methods and compositions
A composition and method for detecting Crohn's disease include the use of serological testing as a rapid and simple way to diagnose Crohn's disease. The serological tests were based on the use of the two recombinant clones isolated from an M. paratubercul...
10/02/2001
5817307Treatment of bacterial infection with oral interferon-଱
Bacterial infections are treated by the administration of alpha-interferon at a dosage of from about 0.1 to about 5 IU/lb./day such that the interferon is held in contact with the patient's oral and pharyngeal mucosae. The method is particularly suitable ...
10/06/1998
5807744Use of interferon γ for the inhibition of proliferation and differentiation of primitive hematopoietic progenitor cells
The invention provides a method for inhibition of proliferation of primitive hematopoietic progenitor cells and hematopoietic stem cells, by incubating preparations containing said cells with IFN-γ. The method is especially useful for protecting said cel...
09/15/1998
5574137Recombinant gamma interferons having enhanced stability and methods therefor
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino ...
11/12/1996
5334504In vitro assay for detecting cell-mediated immune responses
An in vitro method of detecting a cell-mediated immune response to a specific antigen, comprising incubating a whole blood sample with the specific antigen and detecting the presence of gamma interferon released by sensitized lymphocytes in the whole bloo...
08/02/1994
5278286Immune interferon
An intact human immune interferon protein and a method for the extraction and purification of intact recombinant human immune interferon is disclosed. This method permits the purification to homogenity of intact recombinant human immune interferon....
01/11/1994
5273889Gamma-iterferon-leukotoxin gene fusions and uses thereof
New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of le...
12/28/1993
5149636Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products
Multiple copies of a foreign DNA I coding for the production of a protein may be introduced into eucaryotic cells by cotransforming suitable cells with foreign DNA I and with foreign DNA II which includes a functionally deficient, amplifiable gene coding ...
09/22/1992
5145842Protein kinase c. modulators. d.
Compositions having protein kinase C-modulatory, anti-inflammatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class....
09/08/1992
5098703Interferon-alpha 76
A new polypeptide, called IFN-򳅶, produced by E. coli transformed with a newly isolated and characterized human IFN-଱ gene is described. The polypeptide exhibits interferon activities such as antiviral activity, cell growth regulation, and re...
03/24/1992
4992271Formulation for lipophilic IL-2 proteins
An improved process for recovering and purifying lipophilic recombinant proteins such as human ଲ-interferon and interleukin-2 from their hosts yields a protein preparation which may be formulated into a stable pharmaceutical composition having a the...
02/12/1991
4980161Method of treating viral infection in plants
There is disclosed a method of treating or preventing viral infections in plants wherein an animal interferon is applied to the plants....
12/25/1990
4975276Interferon-alpha 54
A new polypeptide, called IFN-򳅔, produced by E. coli transformed with a newly isolated and characterized human IFN-଱ gene is described. The polypeptide exhibits interferon activities such as antiviral activity, cell growth regulation, and re...
12/04/1990
4973479Interferon-򳅡
A new polypeptide, called IFN-򳅡, produced by E. coli transformed with a newly isolated and characterized human IFN-଱ gene is described. The polypeptide exhibits interferon activities such as antiviral activity, cell growth regulation, and re...
11/27/1990
4966843Expression of interferon genes in Chinese hamster ovary cells
DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The h...
10/30/1990
4929554Human immune interferon
Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultu...
05/29/1990
4925793Human immune interferon
Disclosed is a complete description of the preparation of novel, recombinant human immune interferon and des-CYS-TYR-CYS recombinant human immune interferon via recombinant DNA techniques utilizing any of an assortment of expression vectors and host cultu...
05/15/1990
4921698Polypeptide having gamma-interferon activity lacking amino acids coded by exon 4
A polypeptide having gamma-interferon activity which lacks the amino acid sequence coded for by exon 4, a polynucleotide sequence which codes for said polypeptide, a replicable expression vehicle containing said polynucleotide sequence and a transformed m...
05/01/1990
4918019Bioreactor system with plasticizer removal
An improved hollow fiber bioreactor system is disclosed that includes an arrangement for removing the plasticizer that is typically found within the hollow fibers of hollow fiber cartridges so as to prevent this material from contaminating the nutrient fl...
04/17/1990
4883661Use of arginine as an lymphokine synergist
It has been found that arginine serves to increase the receptivity of cells to lymphokines such as interleukin-2 and interferon. An improved method for treating a mammal with one or more lymphokines is disclosed wherein said improvement comprises administ...
11/28/1989
4855409Novel polypeptides and method of producing same
A novel polypeptide which is at least equivalent in biological activity to IFN-γ and is resistant to dimerization and polymerization, a transformant which carries a DNA coding for a novel polypeptide, and a method of producing a novel polypeptide from th...
08/08/1989
4845196Modified interferon gammas
Described are modified human gamma interferons, genes coding for their synthesis and plasmids containing and capable of expressing these genes....
07/04/1989
4845032Process for the isolation and purification of alpha-interferons
The invention relates to a process for the isolation and purification of ଱-interferons by (a) dissolution of the interferon-containing crude product in guandine. HCl solution and precipitation by dilution with water and/or (b) by chromatography on a...
07/04/1989
4835256Human gamma interferon polypeptide having glutamine as the ninth n-terminal amino acid
Disclosed is a novel DNA which shows complementarity to human interferon-γ mRNA, a recombinant plasmid containing the DNA, a microorganism containing the recombinant plasmid and a method of producing the same as well as a process for producing a polypept...
05/30/1989
4832959Preparation of polypeptides having human γ-interferon activity
Partial sequences of human-γ-interferon, comprising aminoacid sequences 5 to 127, 1 to 127 and 5 to 146, having biological activity. These partial sequences can be obtained by a genetic engineering process, for which purpose the appropriate DNA sequences...
05/23/1989
4828990Method for purifying an interferon
A method of purifying a polypeptide having a physiological activity such as one having interferon activities from a culture mixture of a microorganism obtained by a recombinant DNA technique and capable of producing the polypeptide is disclosed. The metho...
05/09/1989
4828989Process for purifying a protein
A process for purifying a protein and particularly the purification of a protein, such as gamma interferon, that forms highly insoluble aggregates during the growth of host cells transformed with DNA sequence coding for the protein....
05/09/1989
4824432Method for treating AIDS and other immune deficiencies and immune disorders
Methods are provided for the treatment of pathological conditions connected with the production of interferons which destroy the immune system and possess damaging action on the cell system of mammals. Interferons are removed from the blood of mammals in ...
04/25/1989
4820514Low dosage of interferon to enhance vaccine efficiency
A biologically active interferon can be administered to an animal in conjunction with the administration of a vaccine to improve the vaccine efficiency and allow the use of a smaller vaccination dose. This procedure will cause a less severe vaccine infect...
04/11/1989
4816566Polypeptides having interferon activity
A polypeptide having interferon activity which has an amino acid sequence corresponding to an amino acid sequence of an interferon selected from rIFN-଱, hybrid rIFN-଱, rIFN-ଲ and rIFN-γ interferons in which at least one cysteine residue...
03/28/1989
4808523Constitutive production of human IFN-댡 by mammalian cells transformed by the IFN-댡 gene fused to an SV40 early promoter
The invention concerns the production of the human fibroblast interferon, IFN-댡 by cells of mammalian origin which are capable of constitutively expressing a DNA sequence encoding for IFN-댡, producing the IFN and secreting it into the surrou...
02/28/1989
4806347Interferon combinations
There are disclosed compositions and methods for treating tumors and viruses in humans by administering a combination of gamma interferon and delta-4 alpha-2 (Bgl II-1)/(Bgl II) alpha-1 hybrid interferon, preferably by injection....
02/21/1989
4801685Microbial production of mature human leukocyte interferon K and L
This invention relates to the microbial production, via recombinant DNA technology, of new human leukocyte interferons, Le IF-K and Le IF-L for use in the treatment of viral and neoplastic diseases, and to the means and end products of such production....
01/31/1989
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