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| Number | Title | Issue Date |
| 7229789 | Methods and compositions for extracting proteins from cells A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective amount of a detergent. ... | 06/12/2007 |
| 6955886 | Scintillation proximity assay for the detection of peptidoglycan synthesis The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan synthesis. ... | 10/18/2005 |
| 6821752 | Methods and compositions for extracting proteins from cells The present invention relates to a process of releasing a protein, recombinant or otherwise, from a cell. The process of the present invention involves contacting a host cell containing a protein of interest with a solution comprising one or more detergents and one ... | 11/23/2004 |
| 6630302 | Methods and compositions for determining species of bacteria and fungi Methods and compositions are described for methods and compositions for determining the species for an unknown bacterium (or fungus) in a sample. The approach, which utilizes Ribosomal operon sequences, permits one to identify important bacteria (or fungi... | 10/07/2003 |
| 6379970 | Analysis of differential protein expression A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that are differentially present in the samples.... | 04/30/2002 |
| 6245296 | Flow immunosensor apparatus Target moiety is detected by (a) providing an antibody specific to the target, (b) saturating the binding sites of the antibody with a labelled form of the target, (c) flowing a liquid containing the target past the saturated antibody, thereby (d) allowin... | 06/12/2001 |
| 6187565 | Photoconversion of organic materials into single-cell protein A process is described for converting organic materials (such as biomass wastes) into sterile, high-grade bacterial protein suitable for use an animal feed or human food supplements. In a preferred embodiment the process involves thermally gasifying the o... | 02/13/2001 |
| 6159682 | Blood control and system for erythrocyte sedimentation measurement A control and system for acute protein plasma measurement. The control includes morphologically fixed and stabilized blood cells that have been added to a diluent.... | 12/12/2000 |
| 5723310 | Aqueous multiple-phase isolation of polypeptide A method is described for isolating an exogenous polypeptide in a non-native conformation from cells, such as an aqueous fermentation broth, in which it is prepared comprising contacting the polypeptide with a chaotropic agent and preferably a reducing ag... | 03/03/1998 |
| 5624841 | Process for the production of thermophilic microorganisms in high yield A process is described for the growth of anaerobic thermophilic heterotrophic methanogens belonging to the species Pyrobaculum islandicum and Pyrococcus furiosus to high cell densities under steady state conditions.... | 04/29/1997 |
| 5529911 | Preparation of granules containing salinomycin Granules containing salinomycin are prepared that are free-flowing, dust-free, and have unrestricted bioavailability of salinomycin. The granules are produced by fermenting a culture broth with a salinomycin producing microorganism to a residual fat conte... | 06/25/1996 |
| 5486368 | Production of a cultured yeast product from whey permeate, yeast cream and yeast centrate A modified cultured yeast product for human and animal consumption is produced by combining yeast cream and yeast centrate to produce a cream/centrate mixture, autolyzing the mixture, inactivating by heating the mixture and optionally drying. After autoly... | 01/23/1996 |
| 5407810 | Aqueous multiple-phase isolation of polypeptide A method is described for isolating an exogenous polypeptide in a non-native conformation from cells, such as an aqueous fermentation broth, in which it is prepared comprising contacting the polypeptide with a chaotropic agent and preferably a reducing ag... | 04/18/1995 |
| 5397711 | Determination of an analyte in a sample liquid The invention concerns a method for the determination of an analyte in a sample liquid by a reaction proceeding in several steps which are separated from one another in time and a suitable reaction vessel for this method.... | 03/14/1995 |
| 5342762 | Fibronectin purification vector Recombinant protein purification vectors and methods for their use are disclosed. The vectors contain a DNA sequence coding for a gelatin binding region of fibronectin. The vectors express a foreign DNA sequence of interest fused to the fibronectin portio... | 08/30/1994 |
| 5314820 | Process and microorganisms for producing single cell protein A methanol-utilizing bacterium selected from the group consisting of Methylophilus KISRI 5 (NCIB 12135), Methylophilus KISRI 6.1 (NCIB 12136), Methylophilus KISRI 512 (NCIB 12137), Methylophilus KISRI 5112 (NCIB 12138) and mutants and variants thereof. Al... | 05/24/1994 |
| 5177003 | Flavored protein products derived from Candida utilis A process is disclosed for improving the flavor of protein products derived from microorganisms which comprises heat treating the microorganism and then drying same in the absence of a centrifugation. Optionally, the microorganism can be cultured in the p... | 01/05/1993 |
| 5106731 | Kaposi's sarcoma endothelial cells and growth factor The present invention relates to a growth factor found in HTLV-II conditioned media and to compositions containing same. The growth factor of the present invention supports the growth of Kaposi's sarcoma endothelial-like cells. The factor has a molecular ... | 04/21/1992 |
| 5049493 | Enhancement of cell growth by expression of a cloned hemoglobin gene The invention relates to nucleotide sequences, including a substantially purified gene which codes for an oxygen-binding protein, and a gene promoter/regulator which is useful in subjecting the translation/transcription of DNA sequences to selective regul... | 09/17/1991 |
| 5008186 | Detection of unique chlamydia strain associated with acute respiratory disease Methods for detecting a unique strain of chlamydia associated with acute respiratory disease are disclosed. These methods utilize monoclonal antibody directed against an antigenic determinant of the TWAR strain of chlamydia. Also disclosed is a method for... | 04/16/1991 |
| 4981653 | Self-indicating strip The present invention relates generally to an analytical reagent test strip for assaying fluid samples. The reagent test strip of this invention has a self-indicating format which provides accurate and reliable results without the need for a color chart o... | 01/01/1991 |
| 4834976 | Monoclonal antibodies to pseudomonas aeruginosa flagella Cell lines have been produced that secrete monoclonal antibodies capable of binding to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa.... | 05/30/1989 |
| 4795708 | Novel backteria and single cell protein production therewith Single cell protein (SCP) is produced at high yields from a novel methanol assimilating Methylomonas sp. grown at elevated temperatures in an aerobic bacterial fermentation process.... | 01/03/1989 |
| 4752564 | Fermentation method and apparatus A process for the production of microbial cells by fermentation of carbonaceous material in a foam fermenter containing an oxygen-enriched nutrient medium. The process uses a source of carbon which is assimilable by the microorganism for the production of... | 06/21/1988 |
| 4707449 | Pichia pastoris yeast strains of enhanced tryptophan content Mutant Pichia pastoris yeasts which produce relatively high levels of tryptophan. These high tryptophan capability Pichia pastoris mutants, grown on such as methanol or glucose, produce improved amino acid balance single-cell protein product reducing the ... | 11/17/1987 |
| 4670397 | Fermentation apparatus Fermentation apparatus useful for conducting aerobic fermentations of microbial cells, particularly at high productivities, is disclosed.... | 06/02/1987 |
| 4663291 | Method for solubilizing microbial protein obtained from Chlamydia trachomatis A method of specimen treatment preparatory to conducting an immunoassay is disclosed whereby a microbial protein is solubilized by a detergent at elevated temperatures and in the presence of an alkali or alkaline earth metal ion. At elevated temperatures,... | 05/05/1987 |
| 4652527 | Process for culturing methylophilus methylotrophus This invention provides a process for single cell protein production which involves the culturing of Methylophilus methylotrophus microorganisms by facultative growth on glucose as a carbon and energy source.... | 03/24/1987 |
| 4643972 | Method and apparatus for multiphase contacting between gas, solid and liquid phases Multiphase contacting between gas, solid and liquid phases is effected using a novel apparatus comprising a cylindrical vessel, a draft tube, a conical bottom and a gas-sparger system. Mild and uniform mixing is achieved within the novel apparatus while s... | 02/17/1987 |
| 4617272 | Enzyme drying process A process for removing the water from an enzyme-containing aqueous medium is disclosed which comprises spraying the medium onto a heated, fluidized bed of inert substrate particles and recovering a dry enzyme concentrate therefrom.... | 10/14/1986 |
| 4617274 | Biochemical conversions by yeast fermentation at high cell densities Novel yeasts are disclosed including Pichia pastoris NRRL Y-11430, yeasts having the characteristics of Pichia pastoris NRRL Y-11430, mutants of Pichia pastoris NRRL Y-11430, and strains derived therefrom. Also disclosed are methods of culturing the strai... | 10/14/1986 |
| 4614717 | Process for cultivation of organisms wherein a uniform protein from microorganisms is enzymatically degraded Products which are soluble without opalescence even at pH 3 and which, because of their reproducible composition, are particularly well suited as a source of nitrogen for organisms are obtained by enzymatic degradation of uniform microbial cell aggregates... | 09/30/1986 |
| 4614651 | Interferon epsilon Disclosed is a new material having antiviral activity designated interferon epsilon. The material may be produced, for example, by exposing primary, diploid human epithelial cells to a virus and then incubating the cells under conditions in which the new ... | 09/30/1986 |
| 4606917 | Synergistic antiviral composition Combinations of 9-(1,3-dihydroxy-2-propoxymethyl) guanine or a pharmaceutically acceptable salt thereof, with ଲ-interferon show a surprisingly high degree of synergism in their activity against viral infections.... | 08/19/1986 |
| 4601986 | Protein product of reduced nucleic acid content and low allergenicity A nucleic acid-reduced substantially allergen-free single cell protein product is obtained by culturing a yeast, fungi or bacterium on an ultra-low sulfate medium, treating the produced cells with a base at a pH of about 9.5 with moderate heat, thereafter... | 07/22/1986 |
| 4596778 | Single cell protein from sulfur energy sources Single cell protein is produced in an aqueous fermentation process employing an oxidizable sulfur energy source plus a carbon dioxide source, such as hydrogen sulfide and carbon dioxide, in a controlled oxygen aqueous environment. The process also can emp... | 06/24/1986 |
| 4514501 | Method for cultivation of microorganism A method for cultivating, under alkaline conditions, microorganisms in a culture medium containing, as a carbon source, the extracted liquor or spent liquor derived from alkaline pulping is presented. In this cultivation, organic acids contained in the ex... | 04/30/1985 |
| 4473641 | Method for producing protein Protein is produced by bacterial degradation of rubber in a nutrient-containing, preferably sterile environment. The resultant protein is particularly useful as an animal feed.... | 09/25/1984 |
| 4439525 | High methionine content Pichia pastoris yeasts Mutant yeasts of the strain Pichia pastoris have been developed which contain relatively high levels of methionine. These high methionine content Pichia pastoris mutants grow on an oxygenated hydrocarbon such as methanol, to produce improved amino acid ba... | 03/27/1984 |
| 4416987 | Method of synthesizing proteins from methanol The invention disclosed provides a method for synthesizing proteins by means of strains of microorganisms improved as regards their performances in using methanol.... | 11/22/1983 |
