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| Number | Title | Issue Date |
| 8143013 | Visible to near-infrared light probe using energy transfer between luciferase and an organic dye via a sugar chain An object of the present invention is to produce a luminescent probe that has less biological effects, efficiently emits visible to near-infrared light, which is excellent for the imaging of individuals, and the use thereof. The present invention provides a sugar ch... | 03/27/2012 |
| 8114622 | Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and... | 02/14/2012 |
| 8043827 | Single molecule-format real-time bioluminescence imaging probe The present invention provides an “in vivo and in vitro real-time bioluminescence imaging means,” which can transmit a detection signal promptly in response to an external signal, while taking advantage of a single-molecule-format luminescent probe as a biolumin... | 10/25/2011 |
| 8043826 | Device for monitoring inhibition of platelet function response The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX 1 inhibitor; mixing the blood with a COX 1-dependent platelet agonist, ... | 10/25/2011 |
| 8039228 | Signal amplification using a synthetic zymogen Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is m... | 10/18/2011 |
| 8030017 | Thermostable luciferases and methods of production Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive ... | 10/04/2011 |
| 7989178 | Colony assay miniaturization with enumeration output A system combining a clonogenic differentiation assay with an instrument-based ATP bioluminescence proliferation assay to produce a standardized colony-forming stem and progenitor cell potency assay is provided. ... | 08/02/2011 |
| 7951551 | Kits and reagents for luciferase detection assay system The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and convenient detection of luciferase activity, such as luciferase reporter e... | 05/31/2011 |
| 7951550 | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. ... | 05/31/2011 |
| 7939286 | Enhancing a luminescent signal Methods and compositions are described for assaying luciferase bioluminescence in vitro and in vivo cells. The compositions provide at least one of enhanced stability of signal or magnitude of signal by varying the composition of the buffer. One or more of the follo... | 05/10/2011 |
| 7906298 | Thermostable luciferase mutant A protein having luciferase activity and at least 60% similarity to luciferase from Photinus pyralis, Luciola mingrelica, Luciola cruciata or Luciola lateralis. Hotaria paroula, Pyrophorus plagiophtalamus, Lampyris noctiluca, Pyrocoelia nayako or Ph... | 03/15/2011 |
| 7883861 | High throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc... | 02/08/2011 |
| 7879575 | Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence The present invention relates to nanostructures for use in luminescent assays as well as methods for the production of nano-sized tube and rods, including arrays of nanotubes and nanorods from a nylon. ... | 02/01/2011 |
| 7824878 | Sensitive method for detecting low levels of ATP Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to noise ratio. The maximum signal to noise ratio can be particularly usef... | 11/02/2010 |
| 7759081 | Annexin proteins and autoantibodies as serum markers for cancer The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also pr... | 07/20/2010 |
| 7741067 | Luciferase-based assays A method and kit is provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to... | 06/22/2010 |
| 7718389 | Stabilizing composition and stabilizing method of coelenterazine solution for high-throughput measurement of luciferase activity The present invention relates to a stabilization composition of coelenterazine or an analog thereof, a kit, a method for measuring a coelenterazine-based biological luminescence, containing coelenterazine or the analog thereof and an antioxidant. ... | 05/18/2010 |
| 7666615 | High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to assays, methods, and kits that provide reagent mixes and instructions for determining the proliferative status of isolated target cell populations. The methods measure the luminescent output derived from the intracellular A... | 02/23/2010 |
| 7666616 | Nucleic acid sequences encoding luciferase for expression in filamentous fungi The present invention relates to genetic reporters. Specifically, the present invention is directed to a modified gene encoding a luciferase for high level expression in an organism with a bias for cytosine (C) or guanine (G) in the third position of the codon. ... | 02/23/2010 |
| 7560245 | Luciferase and methods for measuring intracellular ATP using the same The present invention relates to luciferase having resistance to a surfactant and a method for measuring intracellular ATP which is characterized in that the luciferase having resistance to a surfactant is used in this method comprising the steps of: a first step wh... | 07/14/2009 |
| 7556933 | Reagent system and process for adenosine triphosphate monitoring A reagent system comprises a first reagent which includes a high pH phosphate buffer, and a second reagent which includes luciferase, luciferin, a magnesium salt and an enzyme stabilizer. The second reagent has a low pH and a buffer with a pK which is near the optim... | 07/07/2009 |
| 7521199 | Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds ... | 04/21/2009 |
| 7494781 | Sensitive method for detecting low levels of ATP Methods, devices and systems are provided for detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low molarity... | 02/24/2009 |
| 7459282 | Use of c-Jun or c-Jun activating agents such as UV or c-Jun N-terminal kinases (JNKs) for treating cancer The invention concerns the increased stabilization and activation of p73, a homologue of p53. Specifically, the inventors have determined that c-Jun, a component of the AP-1 family of transcription factors, is necessary for stabilization and activation of p73. Thus,... | 12/02/2008 |
| 7442518 | Imaging regulated protein-protein interactions in cells and living animals by enhanced luciferase protein fragment complementation An enhanced firefly luciferase protein fragment complementation assay method is described that produces a robust and broadly applicable bioluminescence signal and demonstrates both modification-independent and phosphorylation-dependent protein interactions in intact... | 10/28/2008 |
| 7439015 | Methods for detecting DNA viruses A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then detecting the reporter. ... | 10/21/2008 |
| 7435546 | System to detect inducible translocation The present invention relates to a novel method for screening to identify/detect polypeptides capable of translocating into or out of the nucleus of a cell in response to induction by an external stimulus or stimuli. Kits for practicing the method of the invention a... | 10/14/2008 |
| 7425422 | Luciferase detection assay system The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and convenient detection of luciferase activity, such as luciferase reporter e... | 09/16/2008 |
| 7416854 | Luminogenic and nonluminogenic multiplex assay A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided. ... | 08/26/2008 |
| 7396655 | Method for enhancing activity of luciferase with fluorescence activity Methods for enhancing luminescence of a luciferase (BFP-aq) with fluorescence activity derived from a calcium-binding photoprotein are provided. To a luciferase solution with fluorescence activity that contains an apoprotein, a calcium-binding photoprotein, which is... | 07/08/2008 |
| 7384758 | Bioluminescent protease assay with modified aminoluciferin or derivatives thereof A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay employs an aminoluciferin or a carboxy-terminal protected derivative there... | 06/10/2008 |
| 7384751 | Methods of diagnosing muscle damage A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilamen... | 06/10/2008 |
| 7371565 | Apparatus and method for measuring intracellular reactions An intracellular-reaction measuring apparatus for measuring intracellular reactions by the use of a specimen in which a plurality of cell colonies are contained in a non-contact state, the apparatus includes a device that specifies the intensity of first light emitt... | 05/13/2008 |
| 7368232 | High-throughput assay for virus entry and drug screening The present invention provides a rapid virus entry/binding detection assay. An enzyme such as luciferase was incorporated at the C-terminal end of viral envelope proteins of the HIV Nef protein that would specifically associate with cell membranes to deliver the enz... | 05/06/2008 |
| 7364843 | Method of identifying target cell using target cell-specific virus Provided is a method of identifying a target cell using a virus. The method includes infecting the target cell with the virus by contacting the virus to the target cell and culturing the target cell to propagate the virus; adding a chromogenic substrate to the resul... | 04/29/2008 |
| 7354729 | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro... | 04/08/2008 |
| 7354730 | High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc... | 04/08/2008 |
| 7348159 | Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S This invention relates to screening assay methods that can be applied to broad members of the protein kinase gene family and are useful in the detection and evaluation of kinase inhibitors. ... | 03/25/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7329486 | High-throughput assay for virus entry and drug screening The present invention provides a rapid virus entry/binding detection assay. An enzyme such as luciferase was incorporated at the C-terminal end of viral envelope proteins that would deliver the enzyme into the viral particles upon viral assembly. Virus entry/binding... | 02/12/2008 |
