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| Number | Title | Issue Date |
| 7419751 | Titanylphthalocyanine crystal and method of producing the titanylphthalocyanine crystal, and electrophotographic photoreceptor, method, apparatus and process cartridge using the titanylphthalocyanine crystal A titanylphthalocyanine crystal having an X-ray diffraction spectrum having plural diffraction peaks and a primary particle diameter not greater than 0.2 μm, wherein a maximum diffraction peak is observed at a Bragg (2θ) angle of 27.2±0.2°; main peaks are observ... | 09/02/2008 |
| 7348420 | nucleic acid sequences encoding cell surface protein homologues and uses therefore Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall,... | 03/25/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7267835 | Sweetener and process for producing the same The present invention provides a sweetener which has mild sweetness like sugar while maintaining a high sweetness intensity of a Stevia sweetener and also has a sharp head-taste of sweetness, a sharp after-taste of sweetness, as well as reduction of the bitterness a... | 09/11/2007 |
| 7208294 | Display device and display panel driving method A display device and a display panel driving method, in which a matrix panel includes pixel portions each have a series circuit of a bistable element and a light emitting element, every time one scan line is specified in order in accordance with an input image signa... | 04/24/2007 |
| 6921841 | Process for the synthesis of optically active anthracyclines It is described a process for the synthesis of optically active anthracyclines by the fact that the key intermediate (R)2-acetyl-2-hydroxy-1,2,3,4-tetrahydronaphtalene 5,8-dialkoxy-3,4-dihydronaphtalene by acylation asymmetric dihydroxylation, transformation into ch... | 07/26/2005 |
| 6613523 | Method of DNA sequencing using cleavable tags The present invention provides novel systems for sequencing nucleic acid molecules using dNTPs that are 3' end labeled with cleavable tags that block further extension and uniquely identify the bases to which they are attached. Removal of the tags liberat... | 09/02/2003 |
| 6562569 | Arrays with modified oligonucleotide and polynucleotide compositions The present invention provides arrays having associated modified oligonucleotides that selectively bind to DNA or RNA, methods of making such arrays, assays for using such arrays, and the like. In one embodiment, the arrays of the invention exhibit an inc... | 05/13/2003 |
| 6531299 | Cell-free synthesis of polyketides Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.... | 03/11/2003 |
| 6410265 | Gene encoding a putive efflux protein for solvents/antibiotics in Pseudomonas mendocina This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention f... | 06/25/2002 |
| 6399583 | Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof The present invention relates to novel hybrid anthracyclines generated by cloning of fused genes in a mutated Streptomyces galilaeus strain DSM 11638. Said strain was obtained by mutagenization of the S. galilaeus wild type (ATCC 31615). The aglycone moie... | 06/04/2002 |
| 6210930 | Process for preparing doxorubicin The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX. ##STR... | 04/03/2001 |
| 6187758 | Anthracycline glycosides An anthracycline glycoside of formula I ##STR1## wherein R is one of the two following residues: ##STR2## or a pharmaceutically acceptable salt thereof.... | 02/13/2001 |
| 6124105 | Method for detecting the presence of a mycobacterium species and a kit and antibodies for use therein The invention relates to a diagnostic test for the detection and identification of Mycobacterium species in biological specimens of human and animal origin. The test is based on the immunological detection of one or more antigens originating from Mycobact... | 09/26/2000 |
| 6080561 | Variety of Stevia Rebaudiana Bertoni The present invention provides seeds for cultivation of a new variety of Stevia rebaudiana Bertoni, the new variety, a sweetening obtained from dried leaves of the new variety and a process for production of the sweetening.... | 06/27/2000 |
| 6048712 | Process for producing -monoglucosyl hesperidin-rich substance The present process for producing a high -monoglucosyl hesperidin content product is characterized in that it comprises the steps of contacting glucoamylase and -L-rhamnosidase simultaneously or randomly with a solution containing -gl... | 04/11/2000 |
| 5989869 | Process for preparing daunorubicin and doxorubicin The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism involved in the glycosylation of daunorubicin to acid-sensitive, baumyc... | 11/23/1999 |
| 5976830 | Methods of producing doxorubicin The present invention provides novel methods for producing doxorubicin using daunomycin as a substrate. One method employs a genetically engineered host microorganism which is transformed with a vector, preferably a plasmid, which contains the doxA gene. ... | 11/02/1999 |
| 5965407 | Anthracycline compound 0624 The present invention relates to compound 0624 having excellent antitumor activity and antimicrobial activity, which is represented by the general formula (1), and a pharmaceutically acceptable salt thereof. ##STR1## (wherein R represents H or COCH | 10/12/1999 |
| 5955319 | Process for preparing doxorubicin The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.... | 09/21/1999 |
| 5932555 | Terpenoid compound 0406TP-1 The present invention relates to compound 0406TP-1 represented by the general formula (I): ##STR1## wherein Ac represents an acetyl group and Me represents a methyl group, or a pharmaceutically acceptable salt thereof, having excellent antitumor ... | 08/03/1999 |
| 5869298 | Stable mutants of D-N--carbamoylase and process for preparing D--amino acids The present invention relates to mutants of D-N--carbamylase wherein at least one of the cysteines in position 243, 250 and 279 of the amino acid sequence of the wild type enzyme is substituted with a different residue selected from natural amino a... | 02/09/1999 |
| 5843735 | Aklavinone C-11 hydroxylase, gene coding for same, expression vector therefor, and process for preparing hybrid antibiotics by using said vector Aklavinone C-11 hydroxylase separated from Streptomyces sp.; a gene encoding same; an expression vector comprising said gene; a microorganism transformed with said vector; and a process for preparing novel hybrid anthracyclines by using said vector.... | 12/01/1998 |
| 5821098 | Glycosyltransferase gene gtfD from amycolatopsis orientalis The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed heterologous host cells for expressing the GtfD protein, and me... | 10/13/1998 |
| 5756335 | CDC25A and CDC25B proteins, fusion proteins thereof, and antibodies thereto Two previously undescribed human cdc25 genes, designated cdc25 A and cdc25 B, which have been shown to have an endogenous tyrosine phosphatase activity that can be specifically activated by B-type cyclin, in the complete absence of cdc2 are described. As ... | 05/26/1998 |
| 5747312 | Human AlkB polypeptide A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatm... | 05/05/1998 |
| 5702924 | Process for preparing antiparasitic agents Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R1 is H or OH; provided that when X is a single bond, R1 is H or OH, and when X is a double bond, R1 is absent; R2 is H, C | 12/30/1997 |
| 5698528 | Substance IT-62-B and medicinal composition containing the same A substance IT-62-B represented by the following formula (1): ##STR1## a production process thereof, a medicinal composition comprising the compound as an active component, and methods of treating an infectious disease caused by bacteria and a tumor,... | 12/16/1997 |
| 5695966 | DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.... | 12/09/1997 |
| 5691169 | Process for preparing a desired protein A desired protein having the formula: A-B-C-P wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extende... | 11/25/1997 |
| 5681725 | Process for producing heme proteins Process for producing an extracellular heme protein in increased yields, the process comprising culturing an apoprotein producing microorganism in a fermentation medium containing heme or a heme-containing material under conditions permitting the producti... | 10/28/1997 |
| 5665564 | Isolation and characterisation of genes resistant to anthracycline antibiotics Doxorubicin resistance can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 1 or 2 of the accompanying drawings or a restriction fragment derived theref... | 09/09/1997 |
| 5652124 | -glycosyl hesperidin, and its preparation and uses -Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the -bond, is formed by a saccharide-transferring enzyme in a liquid containing hesperidin and -glucosyl sacc... | 07/29/1997 |
| 5652125 | Process for preparing daunorubicin The ability to improve the conversion of &3xb5;-rhodomycinone to daunorubicin can be conferred on a bacterial host transformed with a recombinant vector comprising a DNA coding for an appropriate protein useful for that conversion. Furthermore, the bacter... | 07/29/1997 |
| 5650283 | Biological assay for detecting agonists to the Ah receptor Murine and human Ah receptor cDNAs are provided. These molecules can be used to generate large quantities of Ah-receptor protein. The Ah receptor can be inserted into cell systems such as yeast or mammalian, expressed, and used in assays to detect agonist... | 07/22/1997 |
| 5639735 | Antitumor antibiotic compounds: hayumicins and analogs thereof Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic, particularly antibacterial, activity.... | 06/17/1997 |
| 5597806 | Antifungal agents There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.... | 01/28/1997 |
| 5484712 | Method for producing aclacinomycins A, B, Y using Strepomyces lavendofoliae DKRS Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS(KCTC 0092BP) of the present invention is capable of producing aclac... | 01/16/1996 |
| 5468637 | S. lavendofoliae DKRS cell culture producing anti-tumor aclacinomycins A, B, Y and aglycones Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing acla... | 11/21/1995 |
| 5374552 | Production of pradimicin antibiotics The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and designated as strain AB 1236 (ATCC 55208).... | 12/20/1994 |
