Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7595175 | Polyketides and their synthesis Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or... | 09/29/2009 |
| 7300921 | Polyene polyketides and methods of production Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant... | 11/27/2007 |
| 7241595 | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates The present invention relates to glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates for treating cancers. ... | 07/10/2007 |
| 7217856 | PUFA polyketide synthase systems and uses thereof Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, t... | 05/15/2007 |
| 7211418 | PUFA polyketide synthase systems and uses thereof The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, t... | 05/01/2007 |
| 7211413 | Process for producing purified anthocyanin and crystalline anthocyanin Provided are a process for producing purified anthocyanidin glucoside in which a rhamnose end of anthocyanidin rutinoside is cleaved using rhamnosidase to convert the anthocyanidin rutinoside component into anthocyanidin glucoside, the anthocyanidin glucoside compon... | 05/01/2007 |
| 7160700 | Glycosyltransferase genes A nucleic acid encoding a protein which has an amino acid sequence according to SEQ ID NO: 2, 12, or 14, or the amino acid sequence modified by addition or deletion of one or more amino acids and/or substitution by other amino acids, and which has activity to transf... | 01/09/2007 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 7022825 | Polyketides and antibiotics Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting pol... | 04/04/2006 |
| 7019131 | Programmable one-pot oligosaccharide synthesis The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile ... | 03/28/2006 |
| 7019129 | Dark quenchers for donor-acceptor energy transfer The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes inco... | 03/28/2006 |
| 7018808 | Polyketides and their synthesis and use The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded ... | 03/28/2006 |
| 6958315 | Amphoteric surfactants based upon alkyl polyglucoside The invention relates to a series of polyglycoside derivatives that contain water-soluble groups introduced into the molecule by reaction with the hydroxyl groups present in the starting polyglycoside molecule. The preferred products have more than one water-soluble... | 10/25/2005 |
| 6916660 | Fluorescent sensor compounds for detecting saccharides Fluorescent sensor compounds having the formula: wherein L is selected from the group consisting of alkyl, alkylene, aryl, cycloalkyl, alkoxy, aryloxy, arylalkyl, and arylalkyloxyl; ... | 07/12/2005 |
| 6884604 | Glycorandomization and the production of novel erythronolide and coumarin analogs The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be ... | 04/26/2005 |
| 6797508 | Bioreactor for fermenting solids The invention relates to bioreactor for fermenting solid substrates, comprising a fermentation vessel (2), a device for feeding bioreactive substances and a nozzle arrangement in the fermentation vessel (2). The invention is characterized in that a noz... | 09/28/2004 |
| 6638725 | Method for assaying receptor binding property and reagent for the assay The present invention provides a method capable of simultaneous processing of plural test samples for the receptor binding property of a chemical substance, which does not require immobilization of the receptor or a special device, and a reagent to be use... | 10/28/2003 |
| 6576446 | Process for producing high 2-O--D-glucopyranosyl-L-ascorbic acid Disclosed is a process for producing a high G-AA content product, which comprises the steps of: contacting a solution as a material solution, containing G-AA, L-ascorbic acid, and a saccharide(s), with an anion exchange resin packed in a col... | 06/10/2003 |
| 6531299 | Cell-free synthesis of polyketides Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.... | 03/11/2003 |
| 6521600 | Compound, WF002, production thereof and use thereof The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and... | 02/18/2003 |
| 6511841 | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of ... | 01/28/2003 |
| 6288272 | Continuous process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives The present invention relates to a continuous process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives expressed by the following Formula 1 and more particularly, to the continuous process which enables preparing optically pure (S)-3... | 09/11/2001 |
| 6248579 | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of ... | 06/19/2001 |
| 6183994 | N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted wi... | 02/06/2001 |
| 6174707 | Process for producing L-allysine acetals The present invention has for its object to provide a method for producing an L-allysine acetal which involves a fewer steps and is efficient. This invention relates to method for producing an L-allysine acetal which comprises; converting a D,L-allysine acetal... | 01/16/2001 |
| 6143901 | Complex formation between dsDNA and pyrrole imidazole polyamides Methods and compositions are provided for forming complexes between dsDNA and oligomers of heterocycles, aliphatic amino acids, particularly omega-amino acids, and a polar end group. By appropriate choice of target sequences and composition of the oligome... | 11/07/2000 |
| 6048712 | Process for producing -monoglucosyl hesperidin-rich substance The present process for producing a high -monoglucosyl hesperidin content product is characterized in that it comprises the steps of contacting glucoamylase and -L-rhamnosidase simultaneously or randomly with a solution containing -gl... | 04/11/2000 |
| 6017894 | Actinomadura fulva subsp uruguayensis and antimicrobial complex and antimicrobial compounds isolated therefrom Three novel macrolactam monosaccharides isolated from an antimicrobial complex 510 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. uruguayensis ATCC 53713.... | 01/25/2000 |
| 5939290 | Modified sialyl Lewisx compounds The present invention is drawn to methods for the synthesis of sialyl Lewisx derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemoenzymatic synthesis. The derivatives find use in the treatment and prevention of diseases.... | 08/17/1999 |
| 5925550 | Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex The present invention relates to a method for selectively enhancing the production of factors A2 and/or A3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, ... | 07/20/1999 |
| 5889164 | Chromanol glycoside and method for production thereof This invention provides a novel chromanol glycoside which is a water soluble antioxidant excellent in heat and pH stability and production method thereof. It is a chromanol glycoside represented by the general formula (1): ##STR1## wherein R | 03/30/1999 |
| 5879912 | Method of synthesizing saccharide compositions A method of synthesizing saccharide compositions is described. In this method, an acceptor moiety is contacted with at least one donor saccharide in the presence of at least one cell surface-bound glycosyltransferase specific for catalyzing the coupling o... | 03/09/1999 |
| 5879913 | Process for the production of sophorolipids by cyclic fermentation with feed of fatty acid esters or oils A process for the production of sophorolipids by a stock of Candida bombicola or apicola in a medium that contains a source of nitrogen and a substrate is described. The process includes a first fermentation cycle that includes a stage of growth of the st... | 03/09/1999 |
| 5861293 | Gene encoding glycosyltransferase and its uses This invention relates to glycosyltransferase, genes encoding glycosyltransferase, recombinant vectors having such a gene, host cells transformed with such a recombinant vector, and uses thereof. This invention makes it possible to glycosylate indolopyrro... | 01/19/1999 |
| 5856143 | N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted wi... | 01/05/1999 |
| 5854032 | Biological production of humic acid and clean fuels from coal Coal is treated aerobically or anaerobically to produce humic acid, volatile fatty acids, lower alcohols, and/or methane using a consortium of bacteria designated Mic-1 or KSARC56. This process can also be used to convert aromatic compounds, such as pheno... | 12/29/1998 |
| 5843679 | Method for selectively enhancing the production of factors A or B0 of antibiotic A 40926 complex The present invention is directed to a method for selectively enhancing the production of factors A, and/or B0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above co... | 12/01/1998 |
| 5840861 | A83543 compounds and process for production thereof New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 c... | 11/24/1998 |
| 5837691 | Actinomadura vulgaris subsp vulgaris and antimicrobial complex and antimicrobial A novel macrolactam monosaccharide isolated from an antimicrobial complex 517 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura vulgaris subsp. vulgaris ATCC 53748.... | 11/17/1998 |
| 5827682 | Two-step conversion of vegetable protein isoflavone conjugates to aglucones Disclosed are methods for converting isoflavone conjugates in vegetable protein materials to isoflavone aglucones by forming an aqueous mixture of a vegetable protein material containing isoflavone conjugates, converting the isoflavone conjugates to isofl... | 10/27/1998 |
