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| Number | Title | Issue Date |
| 8119371 | Process for the preparation of polymyxin B employing (PAENI) The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxin B with yield from 1.8 to 2.8 g/l of filtrate of fermentation broth at temperature 28° C., pressure 40−70 kPa,... | 02/21/2012 |
| 7935503 | Methods for producing and using polymyxins The present invention provides methods for producing a polymyxin from an isolated Paenibacillus amylolyticus, and methods for using the polymyxin, including methods for producing a recombinant polypeptide. ... | 05/03/2011 |
| 7927836 | Device and method for the production of biologically active compounds by fermentation The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is located within a working chamber or is adjacent to it. A pressure gradie... | 04/19/2011 |
| 7820411 | -derived vaccine and therapy against botulism A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing ex... | 10/26/2010 |
| 7662592 | Bacteriocin inducer peptides Novel peptides produced by bacteriocin-producing bacteria stimulate the production of bacteriocins in vitro. The producer bacteria are cultured in the presence of a novel inducer bacteria and a peptide having a carboxy terminal sequence of VKGLT in order to achieve ... | 02/16/2010 |
| 7449311 | Method of producing macedocin by culturing The invention relates to the field of bacteriocin producing microorganisms. The invention more specifically relates to the characterization of a novel food grade bacteriocin, namely a lantibiotic, named macedocin and produced by Streptococcus macedonicus ACA-... | 11/11/2008 |
| 7432080 | Process for the production of teicoplanin The present invention provides a newly isolated mutant culture of Actinoplanes teichomyceticus BNG 2315. This culture is capable of producing teicoplanin more than 60 times productivity than those reported before (e.g., Actinoplanes teichomyceticus nov... | 10/07/2008 |
| 7407654 | Antibiotics GE 81112 factors A,B,B1, pharmaceutically acceptable salts and compositions, and use thereof The invention relates to an antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 81112 factor A, factor B1 and factor B, which is produced by fermentation of Streptomyces sp. DSMZ 14386, the pharmaceutically acceptable salts and co... | 08/05/2008 |
| 7396665 | Method of producing FR901228 Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of ... | 07/08/2008 |
| 7378257 | Bacterial superantigen vaccines The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen t... | 05/27/2008 |
| 7335495 | Process for the isolation of pharmaceutical compound cyclosporin a from fungus The present invention describes the development and standardization of a facile method for the isolation and purification of cyclosporin A from a new source, viz., Fusarium nivale and evaluation of its novel antifungal activity against the food spoilage As... | 02/26/2008 |
| 7326689 | Pseudomycins useful against plant diseases Plants and crops subject to attack by fungal related diseases are protected or treated by the application of Pseudomycin compositions which were originally isolated from Pseudomonas syringae. ... | 02/05/2008 |
| 7326782 | Metabolic engineering of viomycin biosynthesis The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes and recombinant host cells comprising a functional fragment of the vi... | 02/05/2008 |
| 7317001 | Use of ramoplanin to treat diseases associated with the use of antibiotics The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be cau... | 01/08/2008 |
| 7314632 | exotoxin A-like chimeric immunogens This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. ... | 01/01/2008 |
| 7312080 | Plant resistance to insect pests mediated by viral proteins The invention involves combining a peptide toxin effective against insects, including but not limited to thrips, leaf hoppers, and beetles, with a transport peptide capable of facilitating transfer of the peptide toxin from the gut of an insect to the hemocoel. The ... | 12/25/2007 |
| 7262268 | Lipopeptide stereoisomers, methods for preparing same, and useful intermediates The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as anti... | 08/28/2007 |
| 7241614 | Methods for producing polypeptides in mutant cells The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequen... | 07/10/2007 |
| 7232800 | Derivatives of magainin and methods of production thereof The present invention provides a Magainin derivative peptide and method of production thereof. Also provided is a pharmaceutically composition comprising said Magainin derivative peptide and pharmaceutically acceptable carrier and/or pharmaceutically compatible bind... | 06/19/2007 |
| 7192743 | Method of producing teicoplanin Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous adsorption resin under selective elution conditions and recovering highl... | 03/20/2007 |
| 7176001 | Manufacture and purification of cyclosporin A The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and f... | 02/13/2007 |
| 7169756 | Streptogramin antibiotics Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond. ... | 01/30/2007 |
| 7157245 | Neisserial vaccine compositions and methods Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria whic... | 01/02/2007 |
| 7144858 | Antibacterial compounds and methods for treating Gram positive bacterial infections The present inventive subject matter relates to novel antibacterial compounds that are capable of inhibiting bacterial multiplication and killing living bacteria. The present inventive subject matter further relates to methods for treating Gram positive bacterial in... | 12/05/2006 |
| 7144991 | Streptavidin expressed gene fusions and methods of use thereof The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genom... | 12/05/2006 |
| 7141395 | Biological control of crown gall disease The present invention provides a method for controlling crown gall disease in plants using an effective quantity of α-proteobacteria that produces trifolitoxin (TFX). The present invention also provides a biocontrol agent for use in the above method, and a plant co... | 11/28/2006 |
| 7141244 | proteins useful for vaccines and diagnostics This invention provides polypeptides of Helicobacter pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for... | 11/28/2006 |
| 7138487 | Extractive purification of lipopeptide antibiotics The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extract... | 11/21/2006 |
| 7125844 | Dabderivatives of lipopeptide antibiotics and methods of making and using the same The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing such compounds, and methods of using the compounds in... | 10/24/2006 |
| 7118749 | Transferrin receptor genes Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminan... | 10/10/2006 |
| 7105317 | Immunogenic compositions comprising vrg-gene products from extracts This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis, or B. bronchiseptica. The inve... | 09/12/2006 |
| 7052874 | Detection of antibacterial activity in excretory secretory product of adult The present invention provides a heat-stable and protease-resistant antibacterial activity in excretory-secretory products (ESP) of Trichuris suis. The antibacterial activity is not more than 10,000 MW; is resistant to boiling, trypsin, and pronase E; has a b... | 05/30/2006 |
| 7045314 | Method for the production of bacterial toxins Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin ex... | 05/16/2006 |
| 7030085 | Thiopeptide compounds A microorganism belonging to the genus Bacillus is cultured and thiopeptide compounds QN3323 and thiocillin I/II compounds are collected from the culture medium. The compounds are useful as drugs to treat infections caused by multidrug-resistant bacteria.... | 04/18/2006 |
| 7018813 | Method for the production of bacterial toxins Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are providing including, but not limited to, addition of toxin ex... | 03/28/2006 |
| 7018814 | Process of purifying vancomycin hydrochloride Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin through a strong acid cation exchange resin, a weak base anion exchan... | 03/28/2006 |
| 7011826 | Control of acidosis The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof, wherein said microorganism is capable of producing lactic acid within the... | 03/14/2006 |
| 6986893 | Method for treating a mucus secretion A method and composition for treating a patient suffering from an excessive mucus secretion includes administration to the patient of a therapeutically effective amount of a botulinum toxin type A, B, C, D, E, F and/or G. ... | 01/17/2006 |
| 6964860 | Glycopeptide antibiotics The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 ... | 11/15/2005 |
| 6962970 | Glycopeptide derivatives and pharmaceutical compositions containing the same Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositi... | 11/08/2005 |
