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| Number | Title | Issue Date |
| 8143028 | B1, alkalophilic enzyme solution and method of producing the same The present invention relates to Bacillus licheniformis B1 strain, alkalophilic enzyme solution and a method for preparing the same, in particular the method for producing cellulase demonstrating optimal activity at pH 10-13 by using Bacillus licheniformis... | 03/27/2012 |
| 8043833 | Expression of soluble therapeutic proteins The present invention provides enhanced methods of producing soluble, active fibroblast growth factor-20 (FGF-20), FGF-21, neurotrophin-3 (NT-3), growth hormone (GH), granulocyte colony stimulating factor (G-CSF), or glucocerebrosidase proteins in microorganisms tha... | 10/25/2011 |
| 8017355 | Mannitol induced promoter systems in bacterial host cells The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading... | 09/13/2011 |
| 7811793 | Process for preparing purified active monomer of bone-derived factor A process for preparing a purified refolded monomer or dimer of a bone-derived factor, which comprises subjecting an inclusion body of a bone-derived factor produced by genetic engineering to the following steps a) to c) in sequence: | 10/12/2010 |
| 7790416 | Mutant strain with increased succinic acid production The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions. ... | 09/07/2010 |
| 7723076 | Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy Methods of detecting interactions of a putative ligand with a selectively labeled target molecule, methods of screening for compounds which bind to a selectively labeled target molecule, methods for calculating the dissociation constant of a ligand that binds to a s... | 05/25/2010 |
| 7642072 | Optimized interferon-beta gene A new nucleic acid molecule that is codon-optimized to expressbeta interferon in Escherichia coli with greater efficacy. ... | 01/05/2010 |
| 7534586 | Method for producing biomass The invention relates to a method for producing biomass from halophilic organisms, in which the halophilic organisms are fermented in a hollow space in a salt dome and said halophilic organisms or components thereof are isolated as biomass. ... | 05/19/2009 |
| 7498155 | Microbial nanowires, related systems and methods of fabrication Conductive nanowires, as are available from a range of bacteria species, methods of use and related device structures. ... | 03/03/2009 |
| 7422863 | Molting hormone receptor and method for screening ligand to the receptor The present invention provides a completely novel molting hormone receptor, which is used for efficiently screening a substance that can be applied to a disinfestant or the like. An insect molting hormone receptor comprising the following polypeptide (a) and polypep... | 09/09/2008 |
| 7419804 | CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use. ... | 09/02/2008 |
| 7396665 | Method of producing FR901228 Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of ... | 07/08/2008 |
| 7374874 | Bacteriophages that infect bacteria (Anthrax) The invention provides bacteriophages that infect Bacillus bacteria, including Bacillus anthracis, and compositions containing the bacteriophages. The invention also provides methods for using the bacteriophages of the invention to prevent and treat in... | 05/20/2008 |
| 7368547 | Use of novel virulence-specific genes as targets for diagnosis and potential control of virulent strains of A method for identifying virulent strains of L. monocytogenes that includes the use of primers or probes in a PCR assay or hybridization technique that employs primers or probes, which are specific for virulence-specific genes of L. monocytogenes. Also... | 05/06/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7341852 | Methods of decoupling reaction scale and protein synthesis yield in batch mode Biological macromolecules are synthesized in vitro in a thin film that provides for high surface area/volume ratio, allowing improved yield in scaled up reactions. ... | 03/11/2008 |
| 7338789 | Methods of in vitro protein synthesis Biological macromolecules are synthesized in vitro under conditions and in a reaction composition wherein oxidative phosphorylation is activated and protein folding is improved. ... | 03/04/2008 |
| 7332304 | Process and materials for production of glucosamine and N-acetylglucosamine A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorga... | 02/19/2008 |
| 7329513 | High level constitutive production of anthrax protective antigen The present invention relates to a process for preparing anthrax protective antigen protein from E. coli using fed batch culture. This process creates a constitutively expressing system for rapid, efficient, cost-effective and high-level production of anthrax... | 02/12/2008 |
| 7329802 | Genetic engineering of cotton to increase fiber strength, water absorption and dye binding An expression cassette having a fiber specific promoter driving expression of a gene encoding an elastic and plastic protein based polymer having the repetitive amino acid sequence Gly-Val-Gly-Val-Pro (SEQ. ID. NO. 2), a terminator, and selectable marker genes for t... | 02/12/2008 |
| 7326545 | antigens and corresponding DNA fragments and uses thereof The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide seque... | 02/05/2008 |
| 7300790 | Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins The present invention relates to non-vaccinal and non-pharmacologic compositions and methods for controlling complex retroviral infections. In particular, the present invention provides transgenic animals expressing a transdominant negative Rex gene product that inh... | 11/27/2007 |
| 7297341 | Chlamydia antigens and corresponding DNA fragments and uses thereof The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polynucleotide molecule... | 11/20/2007 |
| 7297514 | Method for preventing superoxide damage to cells and oxygen-labile proteins A method of reducing superoxide damage to a cell is disclosed. In one embodiment, this method comprises the step of engineering the cell to produce more than a native amount of the YggX protein or its homolog, wherein the cells are rendered more resistant to superox... | 11/20/2007 |
| 7282354 | Method for producing fermented milk product There is provided a fermented milk product that contains lactic acid bacteria capable of producing a large amount of lactotripeptide and a large amount of active ingredient having hypotensive activity and anti-stress effect, and that can be taken pleasantly as foods... | 10/16/2007 |
| 7264949 | Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast The promoter region associated with the Yarrowia lipolytica glycerol-3-phosphate O-acyltransferase (gpat) gene has been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the instant invent... | 09/04/2007 |
| 7258996 | Metalloproteinase inhibitory agent The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The invention also relates to the manufacture of an active agent, in which a fo... | 08/21/2007 |
| 7256018 | Microorganism producing L-threonine having inactivated tyrR gene, method of producing the same and method of producing L-threonine using the microorganism Provided are a microorganism capable of producing L-threonine and having an inactivated tyrR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield. ... | 08/14/2007 |
| 7247453 | Calcium binding recombinant antibody against protein C A Ca2+ dependent recombinant antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C has been constructed. The antibody does not bind to Activated Protein C and can be used... | 07/24/2007 |
| 7244616 | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced express... | 07/17/2007 |
| 7241590 | Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer) The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, ex... | 07/10/2007 |
| 7241614 | Methods for producing polypeptides in mutant cells The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequen... | 07/10/2007 |
| 7241594 | Gene encoding formate dehydrogenases D & E and method for preparing succinic acid using the same Nucleotide sequences encoding formate dehydrogenases D & E and a method for preparing succinic acid using the same, more particularly, formate dehydrogenases D & E converting formate to carbon dioxide and hydrogen, fdhD and fdhE nucleotide sequences encoding the for... | 07/10/2007 |
| 7229794 | Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism Provided are a microorganism capable of producing L-threonine and having an inactivated galR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield. ... | 06/12/2007 |
| 7227010 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the... | 06/05/2007 |
| 7223567 | Mutant strain with increased succinic acid production The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions. ... | 05/29/2007 |
| 7214318 | Method for separation of actinide elements A method for separation of actinide elements comprising feeding a solution containing actinide elements such as americium, curium, californium and the like, into a resin column in which a weakly basic primary, secondary or tertiary anion exchange resin obtained by r... | 05/08/2007 |
| 7214787 | Recombinant vaccine against botulinum neurotoxin This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as w... | 05/08/2007 |
| 7208292 | Nucleic acid encoding an interleukin-9 receptor variant This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One embodiment of the invention is a variant of AAF2 wherein codon 173 is delete... | 04/24/2007 |
| 7202059 | Fusion proteins capable of being secreted into a fermentation medium Fusion protein including a fusion part and a protein of interest, the combination of the two proteins leading to the fusion protein being secreted into a supernatant of a bacterial host with the protein of interest being present in its correct three-dimensional stru... | 04/10/2007 |
