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| Number | Title | Issue Date |
| 8178321 | Recovery and purification of B-phycoerythrin produced by using two-aqueous-phase systems and isoelectric precipitation This invention focuses on a novel process in which Porphyridium cruentum biomass first undergoes a stage of cellular disruption and subsequently stages of recovery and purification in order to achieve the purified B-phycoerythin (BFE) protein dye, using isoel... | 05/15/2012 |
| 8158387 | Method for cell surface display of target proteins using FadL of The present invention relates to an expression vector which can effectively express target proteins or peptides on the surface of cells using an outer membrane protein (FadL) of E. coli as a surface anchoring motif. Also, the present invention relates to micr... | 04/17/2012 |
| 8143027 | Method of making a plasminogen activator polypeptide with clot-specific streptokinase activity The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of na... | 03/27/2012 |
| 8114635 | Methods for obtaining microbial trypsin mutants having chymotrypsin activity The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, 193, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, ... | 02/14/2012 |
| 8093019 | Method for cellulase production A fermentation process using hemicellulose-derived carbohydrates for the production of cellulase mixtures with a high proportion of cellulases relative to hemicellulases is provided. The cellulases produced by the process of the invention are further characterized b... | 01/10/2012 |
| 8084235 | Purification process for bacterial cytolysin The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromato... | 12/27/2011 |
| 8021861 | Pathogenic associated protein The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA poly... | 09/20/2011 |
| 8021862 | Process for preparing human G-CSF The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase. ... | 09/20/2011 |
| 8012716 | Media for clostridium bacterium and processes for obtaining a clostridial toxin Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. T... | 09/06/2011 |
| 8008044 | Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-products using ... | 08/30/2011 |
| 7998705 | Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol The present invention generally relates to novel processes for protein purification in high salt solutions such as cell culture broth by increasing the dynamic binding capacity of a resin with the addition of polyethylene glycol. ... | 08/16/2011 |
| 7972814 | Antimicrobial polypeptides from The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic aci... | 07/05/2011 |
| 7951561 | Method for the preparation of κ-carrageenase Halophilic marine gram negative bacteria, isolated from decayed algae, hydrolyzed κ-carrageenan. To maximize κ-carrageenase production in the cost effective manner, a novel medium was defined having minimum components and their optimum concentration by statistical... | 05/31/2011 |
| 7939298 | Fermentation process using specific oxygen uptake rates as a process control Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invent... | 05/10/2011 |
| 7932056 | Crustaceans as production systems for therapeutic proteins A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a ge... | 04/26/2011 |
| 7919275 | Oxaloacetate hydrolase deficient fungal host cells An isolated mutant host cell produced by disrupting or deleting, in a parent cell, a nucleic acid sequence encoding an oxaloacetate hydrolase, or a promoter thereof, which results in the mutant cell producing less of the oxaloacetate hydrolase than the parent cell i... | 04/05/2011 |
| 7855059 | Fermentation with cyclic pulse-pause feeding A process for the production of a valuable compound, comprising the steps of a) fermentation of a filamentous bacterial or fungal strain (e.g. a Streptomyces strain or an Aspergillus strain) in a fermentation medium wherein a carbohydrate during fermen... | 12/21/2010 |
| 7771971 | Methods for producing biological substances in enzyme-deficient mutants of The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Aspergillus niger strain in a medium suitable for the production of the heterologous biological substance, wherein (i) ... | 08/10/2010 |
| 7700322 | Method for stable gene-amplification in a bacterial host cell A bacterial host cell comprising at least two copies of an amplification unit in its genome, said amplification unit comprising: i) at least one copy of a gene of interest, and ii) an expressible conditionally essential gene, wherein the conditionally essential gene... | 04/20/2010 |
| 7642071 | Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts The present invention relates to a Gram-negative glycosaminoglycan gene and methods of making and using same. The present invention relates to recombinant Gram-positive host cells containing a Gram-negative glycosaminoglycan synthase gene, and methods of producing g... | 01/05/2010 |
| 7592159 | Antibiotic alternatives The present invention relates to two recombinant colicin expression systems, one utilizing a yeast expression system that produces a protein that is inexpensive to purify, and the other utilizing a plasmid expression system to be used as a probiotic culture. The rec... | 09/22/2009 |
| 7579171 | Ascorbic acid production from yeast Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a Zygosaccharomyces spp. or a Kluyveromyces spp. growing in a medium comprising an ascorbic acid precursor. In a second embodiment the yeast is a recom... | 08/25/2009 |
| 7575899 | Microorganism of the genus having enhanced L-lysine productivity and method of producing L-lysine using the microorganism of the genus The present invention provides a microorganism that belongs to the genus Corynebacterium and has an inactivated inherent NCgl2053 dehydrogenase gene, and a method of producing L-lysine using the same. By using the microorganism, the yield of L-lysine is incre... | 08/18/2009 |
| 7560251 | Media for bacterium Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. T... | 07/14/2009 |
| 7547529 | Methods for reducing the formation of by-products in the production of recombinant polypeptides A method for reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium in a method for producing a polypeptide containing a serine resi... | 06/16/2009 |
| 7544493 | Method for the purification of an N-terminal fragment of hepatocyte growth factor A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell, isolation of inclusion bodies containing said NK4 in denatured form, solubili... | 06/09/2009 |
| 7452697 | Chromatographic method and system for purifying a botulinum toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... | 11/18/2008 |
| 7445914 | Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-p... | 11/04/2008 |
| 7442527 | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the develo... | 10/28/2008 |
| 7435574 | NADH oxidase from The present invention is directed to a new NADH oxidase from Lactobacillus, nucleic acids encoding the NADH oxidase, methods of producing the NADH oxidase, as well as there use in producing improved NADH oxidase enzymes and for producing chrial enantiomer-enr... | 10/14/2008 |
| 7435570 | Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use The invention relates to novel variants of cytochrome P450 oxygenases. These variants have at least one mutation improving their ability to use peroxide as an oxygen donor as compared to the corresponding wild-type enzyme. The variants also have at least one mutati... | 10/14/2008 |
| 7435553 | Isolating cells expressing secreted proteins A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic... | 10/14/2008 |
| 7432095 | Formate dehydrogenase tolerant to halogen compounds and process for producing the same The invention provides a formate dehydrogenase having high specific activity, small Km values for formate and NAD, broad temperature and pH ranges of stability, broad temperature and pH ranges for action, and capable of regenerating a coenzyme with good efficiency i... | 10/07/2008 |
| 7429649 | Modification of lignin biosynthesis The present invention relates to the modification of lignin biosynthesis in plants, using the nucleotide sequences encoding the enzymes 4-coumarate CoA-ligase (4CL), cinnamoyl-CoA reductase (CCR), cinnamyl alcohol dehydrogenase (CAD) of the lignin biosynthetic pathw... | 09/30/2008 |
| 7425324 | Antagonists of MCP proteins Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated following non-conservative substitutions. Compounds prepared in accordance w... | 09/16/2008 |
| 7425433 | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and variants are also provided as methods for use of recombinant biocatalytic re... | 09/16/2008 |
| 7422884 | Feedback-resistant mevalonate kinases The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The ... | 09/09/2008 |
| 7419801 | Methods of protein production in yeast Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, an... | 09/02/2008 |
| 7419814 | Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine kinase type 2 isoform is produced in the cell, adding at least one drug ... | 09/02/2008 |
| 7419813 | Fructosyl peptide oxidase The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis, and an object of providing a method for producing the fructosyl peptid... | 09/02/2008 |
