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| Number | Title | Issue Date |
| 6974681 | Cell culture performance with vanadate The invention provides methods and compositions for improved in vitro culture of cells that make use of vanadate. The methods enhance cell survival thereby recovery of the polypeptide of interest produced in the cells is increased relative to cells grown without van... | 12/13/2005 |
| 6913924 | Population of interferon producing cells Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided. ... | 07/05/2005 |
| 6855519 | Methods for enhancing the production of interferon in cell culture Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-dependent kinas... | 02/15/2005 |
| 6607914 | Camello gene family and uses thereof The present invention provides a purified and isolated nucleic acid encoding a camello protein. The present invention also provides a vector comprising nucleic acid encoding camello, a host cell transformed with the vector, and a method for producing reco... | 08/19/2003 |
| 6489144 | Methods for enhancing the production of interferon in cell culture Methods for enhancing the production of interferon in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-depen... | 12/03/2002 |
| 6312924 | Murine interferon- Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and ... | 11/06/2001 |
| 6159712 | Methods for enhancing the production of interferon in cell culture Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-depe... | 12/12/2000 |
| 6156542 | Method for production of native human leukocyte (alpha) interferon The invention relates to a process for the preparation of natural human alfa interferon from human blood by ammonium chloride haemolysis and purification by washing with buffered physiological saline solution, then preparing a suspension in a liquid cultu... | 12/05/2000 |
| 5891443 | Method to produce granulocyte colony stimulating factor from immortalized avian T lymphocytes to produce immortalized cells Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized in vivo. The activated T cells are first exposed in vitro t... | 04/06/1999 |
| 5856179 | Polypeptide production in animal cell culture A method of producing a polypeptide in fed batch cell culture is provided which involves an initial cell growth phase and a distinct production phase. In the initial growth stage, animal cells having nucleic acid encoding the polypeptide are cultured at a... | 01/05/1999 |
| 5834249 | Process for production of protein A process for production of a desired protein comprising the steps of: a culturing animal cells capable of producing the desired protein in a medium containing trichostatin compounds; and recovering the desired protein from the culture.... | 11/10/1998 |
| 5731193 | Recombinant DNA and transformant containing the same Insertion of IFN-alpha promoters in recombinant DNAs improves their expression efficiencies for useful polypeptides. Expression of such a recombinant DNA in host cells of mammalian origin is artificially controllable by the presence and absence of externa... | 03/24/1998 |
| 5698194 | Method for making a medicament for treating secondary immunodeficiency A method of producing a natural nonrecombinant cytokine mixture is disclosed including the steps of immobilizing at least one mitogen in a tissue culture vessel. An isolated population of lymphocytes free of neutrophils and erythrocytes, is suspended in a... | 12/16/1997 |
| 5676942 | Composition containing human alpha interferon species proteins and method for use thereof This invention provides alpha interferon compositions comprising one or a mixture of selected highly antiviral interferon proteins, which compositions are characterized by increased anti-viral activity. These compositions may be used therapeutically in th... | 10/14/1997 |
| 5672692 | Purification of human myelomonocyte interferon gamma with an immobilized antibody A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being implanted in a non-human warm-blooded animal or in a diffusion cham... | 09/30/1997 |
| 5563120 | Cytokine preparation for immunotherapy A cytokine composition is prepared for use in immunotherapy of various diseases. The composition is prepared by culturing leucocytes previously infected with a virus in a culture medium containing a transal composition isolated from plasma and a complex o... | 10/08/1996 |
| 5554515 | Preparation of a monoclonal antibody specific to human myelomonocyte interferon-gamma A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being implanted in a non-human warm-blooded animal or in a diffusion cham... | 09/10/1996 |
| 5518899 | Preparation of human myelomonocyte interferon-gamma The present invention relates to a novel human interferon-gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte interferon-gamma has a novel polypeptide and carbohydrate cha... | 05/21/1996 |
| 5362490 | Human myelomonocyte interferon-gamma, and process for preparation and use thereof The present invention relates to a novel human interferon-gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte interferon-gamma has a novel polypeptide and carbohydrate cha... | 11/08/1994 |
| 5308626 | Lymphokine activated effector cells for antibody-dependent cellular cytotoxicity (ADCC) treatment of cancer and other diseases This invention relates to processes and compositions for the immunotherapeutic treatment of cancer and non-malignant tumors. More particularly, this invention relates to processes and compositions for enhancing the body's immune response by increasing the... | 05/03/1994 |
| 5272082 | Cytotoxic T-ALL cell lines and uses therefor The invention provides cytotoxic T-ALL cell lines, and modified cytotoxic T-ALL cell lines which contain a heterologous DNA sequence. The DNA sequence may encode a product capable of stabilizing or potentiating the tumoricidal activity of the cytotoxic ce... | 12/21/1993 |
| 4966843 | Expression of interferon genes in Chinese hamster ovary cells DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The h... | 10/30/1990 |
| 4948730 | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the... | 08/14/1990 |
| 4929443 | Method of treating interferon sensitive diseases, and a method and device for preparing γ-interferon containing preparation Methods and means for treating interferon-sensitive diseases are disclosed, wherein a whole blood sample is taken from a patient suffering from such disease and is incubated in vitro together with a mitogen to produce γ-interferon. After incubation the w... | 05/29/1990 |
| 4908432 | Novel polypeptide having gamma-interferon activity The present invention provides a peptide having an amino acid sequence of less than about 100 amino acids, immunochemically reactive with an antibody directed against human gamma-interferon, and displaying gamma-interferon antiviral and cytolytic activiti... | 03/13/1990 |
| 4882147 | Novel polynucleotide analogs, methods for inhibiting nucleic acid polymerases and methods for inducing synthesis of interferon Polyribonucleotide analogs which are partially substituted by the introduction of mercapto groups and fluorine at the 5-position of some of their cytosine and uracil bases possess effective in vivo antitumor activity. Double stranded complexes formed from... | 11/21/1989 |
| 4803163 | Preparation of a protein fraction exhibiting cell growth-inhibiting activity A protein fraction isolated from tissue cultures of human diploid fibroblasts or lymphoblastoid cells inhibits the growth of heterologous human cells.... | 02/07/1989 |
| 4764461 | Tellurium and selenium compounds for the induction of in vivo and in vitro production of cytokines Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and their receptors. These compounds may be utilized in the treatment of certain tumors, autoimmune diseases, immune diseases and... | 08/16/1988 |
| 4758510 | Simplified in-vitro interferon production Interferon is produced in-vitro from whole blood, obtainable from animals or humans including blood from corpses or retroplacental blood, in a simplified non-critical process preferably carried out in a sterile system of interconnected plastic bags. The b... | 07/19/1988 |
| 4723000 | Human interferon gamma and interleukin-2 A process for producing unique human interferon gamma and interleukin-2 by chromatographic fractionation utilizing ion exchange and metal chelate chromatography. The interferon gamma and interleukin-2 are purified from crude interferon obtained by mitogen... | 02/02/1988 |
| 4696899 | Process for the preparation of human leukocyte and human gamma interferon The invention relates to a process for the preparation of - and γ-interferon by isolating the buffy coat fraction of blood, removing the erythrocytes, suspending the leukocytes in a suitable nutrient medium and treating with an -interferon ... | 09/29/1987 |
| 4683199 | Interleukin-2 dependent cytotoxic T-cell clones Interleukin-2 dependent cytotoxic cultured T-cell lines are found to produce , ଲ, and γ interferon, as well as interleukin-2, when stimulated by mitogenic or antigenic agents.... | 07/28/1987 |
| 4680261 | Process for producing interferon A process for producing interferon comprises culturing interferon-producing mammalian cells in a cell culture medium containing at least one compound selected from the group consisting of ascorbic acid, an ascorbic acid derivative and a vanadium compound.... | 07/14/1987 |
| 4617378 | Purification of biologically active human immune interferon There is provided a process for purification of human immune interferon (IFN-γ) to homogeneity without appreciable loss of biological activity by the use of chromatography on controlled-pore glass, ultrafiltration and high performance cation exchange chr... | 10/14/1986 |
| 4614651 | Interferon epsilon Disclosed is a new material having antiviral activity designated interferon epsilon. The material may be produced, for example, by exposing primary, diploid human epithelial cells to a virus and then incubating the cells under conditions in which the new ... | 09/30/1986 |
| 4606917 | Synergistic antiviral composition Combinations of 9-(1,3-dihydroxy-2-propoxymethyl) guanine or a pharmaceutically acceptable salt thereof, with ଲ-interferon show a surprisingly high degree of synergism in their activity against viral infections.... | 08/19/1986 |
| 4591557 | Process and materials for producing soluble biological mediators from white blood cells A process and cellular system for producing soluble biological mediators, including cytokines, lymphokines, monokines and interferons, and mRNA therefor, from white blood cells is provided. The process involves treating white blood cells with a mitogenic ... | 05/27/1986 |
| 4548900 | Method of interferon production A method for the mass production of interferon, wherein cultured cells are brought into contact with at least one polyhydric alcohol, thereby achieving a remarkable increase in the production of interferon from the cultured cells.... | 10/22/1985 |
| 4541952 | Purification method of human interferon A method for the purification of human interferon by the successive treatments of a crude interferon solution with an immobilized carrier which is coupled with a blue dye and a chelating carrier which contains a chelating residue chelated with at least on... | 09/17/1985 |
| 4526782 | Process for recovering interferon Interferon can be recovered simply by contacting an aqueous solution containing interferon which is induced and produced from cells of human origin capable of producing interferon, with a siliceous substance to adsorb interferon on it and eluting the adso... | 07/02/1985 |
