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| Number | Title | Issue Date |
| 8021860 | Method for producing human antibodies to a self physiological receptor by site-directed in vitro immunization of human lymphocytes A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A ... | 09/20/2011 |
| 7364842 | Methods of identifying modulators of human retrovirus replication This invention relates to the discovery that the transcription factors Pbx1 and HMG I are involved in retrovirus, e.g., HIV, replication. Thus, the invention provides methods of identifying modulators of these proteins. Such modulators can be used as reagents in in ... | 04/29/2008 |
| 7258998 | Cell culture medium A method for culturing cells in the presence of an alcanoic acid for enhancing protein production. ... | 08/21/2007 |
| 7220559 | Development of human monoclonal antibodies and uses thereof This invention provides: a heteromyeloma, other than B6B11, capable of producing a trioma when fused with a human lymphoid cell, wherein the trioma is capable of producing a monoclonal antibody-secreting tetroma when fused with a second, antibody-secreting human lym... | 05/22/2007 |
| 7030100 | Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of effectors for cGMP are not fully understood in the processing of pain in th... | 04/18/2006 |
| 6927279 | Antithrombin nucleotides and proteins from horn fly Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins. The protein named thrombostasin is isolated from the salivary glands of... | 08/09/2005 |
| 6913924 | Population of interferon producing cells Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided. ... | 07/05/2005 |
| 6911324 | Induction of beta cell differentiation in human cells The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene and a NeuroD/BETA2 gene with a GLP-1 receptor agonist, wherein the ... | 06/28/2005 |
| 6660523 | Dendritic cells; methods Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.... | 12/09/2003 |
| 6436411 | Cancer treatment method Treatment of tumors, including their metastases, is described. Retrieved cytokines and other molecules from the growth medium of human monocytes stimulated ex vivo with gamma globulin, or other immune stimulators are employed for cancer therapy.... | 08/20/2002 |
| 6300314 | Hematopoietic stimulation Methods and products for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells are provided. The methods and products can be used both in vivo and in vitro. The meth... | 10/09/2001 |
| 6156542 | Method for production of native human leukocyte (alpha) interferon The invention relates to a process for the preparation of natural human alfa interferon from human blood by ammonium chloride haemolysis and purification by washing with buffered physiological saline solution, then preparing a suspension in a liquid cultu... | 12/05/2000 |
| 6093802 | Glial cell line-derived neurotrophic factor A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequ... | 07/25/2000 |
| 6063593 | TGF댡 responsive bone marrow derived cells to express a recombinant protein A method for expressing a recombinant protein from bone marrow-derived cells comprises the steps of treating the bone marrow-derived cells in vitro with a TGF댡 protein, which selects a population of the cells for further treatment. The selected cel... | 05/16/2000 |
| 6033885 | Integrative recombinant adenoviruses, preparation thereof and therapeutical uses thereof The present invention relates to recombinant adenoviruses having a cassette capable of integrating into the genome of infected cells, their preparation, pharmaceutical compositions containing them, and their use. In particular, the cassette contains at le... | 03/07/2000 |
| 5932700 | Protein inhibiting the growth of human endometrial fibroblasts A novel cell growth-inhibiting protein is provided. The cell growth-inhibiting protein, obtainable from extract of human uterine endometrial carcinoma, has the amino acid sequence rich in hydrophobic residue at its N-terminal, has a molecular weight of ab... | 08/03/1999 |
| 5856159 | Production of galactosyltransferase A gene expression system for producing galactosyltransferase comprises an NSO cell recombinantly modified with a polynucleotide encoding galactosyltransferase or a portion thereof which catalyzes the reaction: UDP-D-galactose+N-acetylglucosamine.fwdarw.UDP+D-g... | 01/05/1999 |
| 5804186 | Nerve cell differentiation promoter A nerve cell differentiation promoter which comprises a physiologically active substance NK175203 or a pharmacologically acceptable salt thereof as an active ingredient is provided. It is expected that the nerve cell differentiation promoter of the presen... | 09/08/1998 |
| 5770398 | Vector for integration site independent gene expression in mammalian host cells Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type re... | 06/23/1998 |
| 5770449 | Vector for integration site independent gene expression in mammalian host cells which permit immunoglobulin gene expression A vector for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell. The vector comprises a promoter and the gene and in an immunoglobulin dominant control region derived from the ... | 06/23/1998 |
| 5744456 | Methods for obtaining production of a gene product in a host cell in vivo or in vitro using a DNA molecule for integration site independent gene expression Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type re... | 04/28/1998 |
| 5736359 | Isolated DNA molecules for integration site independent gene expression in mammalian host cells Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type re... | 04/07/1998 |
| 5710251 | Purification of bacterially expressed human interleukin-10 Disclosed is a method for purifying Interleukin-10 (IL-10). The method is comprised of subjecting an IL-10 containing solution to cation exchange chromatography, anion exchange chromatography, hydroxyapatite chromatography, and gel filtration chromatograp... | 01/20/1998 |
| 5698194 | Method for making a medicament for treating secondary immunodeficiency A method of producing a natural nonrecombinant cytokine mixture is disclosed including the steps of immobilizing at least one mitogen in a tissue culture vessel. An isolated population of lymphocytes free of neutrophils and erythrocytes, is suspended in a... | 12/16/1997 |
| 5665593 | Antisense oligonucleotides which combat aberrant splicing and methods of using the same A method of combatting aberrant splicing in a pre-mRNA molecule containing a mutation is disclosed. When present in the pre-mRNA, the mutation causes the pre-mRNA to splice incorrectly and produce an aberrant mRNA or mRNA fragment different from the mRNA ... | 09/09/1997 |
| 5643881 | Protein having anti-HIV activity and method for obtaining it A protein having potent anti-HIV activity is obtained by a method which comprises culturing a strain of CD4-positive T cells, such as a subclone of CEM cells designated 4084, in a tissue culture medium under conditions in which the cells are induced to pr... | 07/01/1997 |
| 5563120 | Cytokine preparation for immunotherapy A cytokine composition is prepared for use in immunotherapy of various diseases. The composition is prepared by culturing leucocytes previously infected with a virus in a culture medium containing a transal composition isolated from plasma and a complex o... | 10/08/1996 |
| 5540919 | Method for enhancement of production of lymphokines and applications thereof Disclosed is a method for enhancing the production of T cell lymphokines, which comprises exposing T cell lymphocytes which have a potential to make selected T cell lymphokines to an appropriate concentration of at least one particular steroid hormone pri... | 07/30/1996 |
| 5518914 | Growth medium containing a complex of prealbumin, a retinoid and retinol-binding protein used to enhance B cell growth This invention provides a complex consisting essentially of prealbumin, retinol-binding protein, and a retinoid which binds to retinol-binding protein, wherein the concentration of retinoid in the complex is from about 2×10-5 M to about 10 | 05/21/1996 |
| 5505944 | Physiologically active substance NK175203, process for production thereof and pharmaceutical use thereof Physiologically active substance NK175203 is produced by culturing bacteria belonging to the genus Streptomyces and capable of producing the physiologically active substance NK175203, and collecting the produced and accumulated substance. The physiologica... | 04/09/1996 |
| 5487982 | Method of obtaining immunogenic peptides from cells expressing temperature-sensitive mutants of major histocompatibility complex molecules Genetically engineered temperature-sensitive class I HLA mutants are provided which can be used in a method to obtain peptides which are bound to MHC class I molecules on the surfaces of cells that are transfected with the mutant genes.... | 01/30/1996 |
| 5480782 | Process for obtaining cellular protein having anti-HIV activity A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV ... | 01/02/1996 |
| 5474897 | Screening assay for the identification ov novel immunosuppressives using cultured T cells A method for identifying compounds capable of inducing immunosuppression by inhibiting the CD28 signal transduction pathway and T cell comprises exposing cultured T cells to one or more test compounds. The T cells are obtained from a T cell line which sta... | 12/12/1995 |
| 5470730 | Method for producing TH -independent cytotoxic T lymphocytes The present invention relates to cytotoxic T lymphocytes (CTLs) which have been converted to a helper T cell independent phenotype by introducing a recombinant expression vector encoding IL-1 receptor into the CTL. The resulting CTLs have the ability to g... | 11/28/1995 |
| 5346988 | Process for obtaining cellular protein having anti-HIV activity A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV ... | 09/13/1994 |
| 5328989 | Purification of human interleukin-10 from a cell culture medium A method for purifying Interleukin-10 (Il-10) from a eukaryotic cell culture medium. The method is comprised of subjecting IL-10 containing cell culture medium to cation exchange chromatography, anion exchange chromatography, hydroxyapatite chromatography... | 07/12/1994 |
| 5308626 | Lymphokine activated effector cells for antibody-dependent cellular cytotoxicity (ADCC) treatment of cancer and other diseases This invention relates to processes and compositions for the immunotherapeutic treatment of cancer and non-malignant tumors. More particularly, this invention relates to processes and compositions for enhancing the body's immune response by increasing the... | 05/03/1994 |
| 5294544 | Biologically active factor The invention comprises a factor having the following characteristics: a) It inhibits granulocyte-macrophage colony and cluster formation; b) It has a molecular weight of about 8 kDa as determined by SDS-PAGE; c) It has a weak anionic charge at pH 7.4 as shown by anion ... | 03/15/1994 |
| 5290688 | Method for intensive, in vitro culture of Babesia divergens strains Method for the culture of Babesia divergens, characterized in that the Babesia strain is maintained under culture in a culture medium free from serous protein but containing lipoproteins and red blood corpuscles, and a method for preparing exoantigens and... | 03/01/1994 |
| 5290681 | Method of assaying immunization stimulating activity A method of assaying immunization stimulating activity comprising (a) immunizing a lymphocyte in vitro by culturing the lymphocyte in contact with an immobilized antigen in a medium containing a test substance and (b) detecting an immunoglobulin, which is... | 03/01/1994 |
