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| Number | Title | Issue Date |
| 8137934 | Regeneration and neogenesis of retinal photoreceptor cell using Otx2 gene The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an agent for preventing, treating or suppre... | 03/20/2012 |
| 7858346 | Regeneration and neogenesis of retinal visual cell-expressing Otx2 protein The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an agent for preventing, treating or suppre... | 12/28/2010 |
| 7807417 | Ecdysone receptor-based inducible gene expression system This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene ex... | 10/05/2010 |
| 7741079 | Method of making a genetically modified mammalian cell A method of making a genetically modified mammalian cell, the method including selecting a first codon of a parent polynucleotide that encodes a polypeptide for replacement with a synonymous codon, wherein the synonymous codon is selected on the basis that it exhibi... | 06/22/2010 |
| 7709229 | Serum-free cell culture medium for mammalian cells This invention relates to a process for the manufacturing of a protein in mammalian cells cultured in a serum-free medium. ... | 05/04/2010 |
| 7662591 | Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory s... | 02/16/2010 |
| 7659094 | Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory s... | 02/09/2010 |
| 7655441 | Nucleic acid sequences having gene transcription regulatory qualities The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory s... | 02/02/2010 |
| 7608431 | Fed-batch process for production of erythropoietin in human embryonic retina cells that express adenovirus E1A The invention provides processes for recombinant production of erythropoietin (EPO) in a human embryonic retina cell that expresses at least an adenoviral E1A protein, wherein said EPO is produced at high concentrations and wherein said EPO as produced has a high av... | 10/27/2009 |
| 7468260 | Method of detecting and using an expression-enhancing sequence The invention relates to a method of detecting a DNA sequence which at least partially contributes to promote the stable expression of a gene. To this end the DNA fragment to be examined is cloned in a vector between i) a DNA sequence involved in the induction of ge... | 12/23/2008 |
| 7439037 | Use of aminoglycoside resistance gene Use of aminoglycoside resistance gene product for achieving high-density growth of animal cells. ... | 10/21/2008 |
| 7435553 | Isolating cells expressing secreted proteins A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic... | 10/14/2008 |
| 7429459 | Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloidal-be... | 09/30/2008 |
| 7410778 | Estrogen receptor genes and utilization thereof A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid sequence of SEQ ID NO: 1, (b) an estrogen receptor comprising the amino a... | 08/12/2008 |
| 7364842 | Methods of identifying modulators of human retrovirus replication This invention relates to the discovery that the transcription factors Pbx1 and HMG I are involved in retrovirus, e.g., HIV, replication. Thus, the invention provides methods of identifying modulators of these proteins. Such modulators can be used as reagents in in ... | 04/29/2008 |
| 7335491 | Production of anti-abeta An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 02/26/2008 |
| 7312309 | PRO6017 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 12/25/2007 |
| 7309769 | PRO1487 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 12/18/2007 |
| 7300773 | Production of TNFR-Ig An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 11/27/2007 |
| 7294484 | Production of polypeptides An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 11/13/2007 |
| 7291484 | Processes for culturing E1-immortalized cells to increase product yields The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® (human embryonic retina) cells, to improve product yields from such cells. Feed strategies for such cells and c... | 11/06/2007 |
| 7276352 | Induction of β cell differentiation in human cells by stimulation of the GLP-1 receptor The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured... | 10/02/2007 |
| 7270990 | Virus production An improved process for recovery of virus from allantoic fluid of virus-infected chick embryos. Virus associated with granular and fibrous debris in the allantoic fluid can be disassociated from the debris and recovered, thereby increasing viral yield. Dissociation ... | 09/18/2007 |
| 7264923 | Norovirus infected cell cultures and uses therefor A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a defic... | 09/04/2007 |
| 7258998 | Cell culture medium A method for culturing cells in the presence of an alcanoic acid for enhancing protein production. ... | 08/21/2007 |
| 7255879 | Post-partum mammalian placenta, its use and placental stem cells therefrom The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood b... | 08/14/2007 |
| 7250294 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells This invention provides populations of neural progenitor cells and differentiated neurons, obtained by culturing pluripotent cells in special growth cocktails. The technology can be used to produce progenitors that proliferate through at least ˜40 doublings, while ... | 07/31/2007 |
| 7244578 | Methods for modeling infectious disease and chemosensitivity in cultured cells and tissues The present invention provides methods for utilizing a form of optimized suspension culture to examine the infectivity of pathogenic organisms and agents in human cells and tissues. Also provided are methods using a rotating wall vessel to predict chemosensitivity o... | 07/17/2007 |
| 7244401 | Apparatus for separation of constituents from matrices The present invention provides an apparatus useful for the separation of hazardous and non-hazardous organic and inorganic constituents from various matrices. A method of separating such constituents is also provided. ... | 07/17/2007 |
| 7198920 | HER-2/neu fusion proteins The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the HER-2/neu fusion ... | 04/03/2007 |
| 7198947 | Production of functional proteins: balance of shear stress and gravity The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-a... | 04/03/2007 |
| 7192741 | DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory s... | 03/20/2007 |
| 7186428 | Method of oxygenating yeast slurry using hydrophobic polymer membranes Disclosed is a an economical method of efficiently oxygenating yeast slurry without bubble formation. The method employs a membrane oxygenator comprising at least one hydrophobic, microporous membrane having a gas side and a liquid side. The yeast slurry flows over ... | 03/06/2007 |
| 7129334 | Synthetic peptide and uses for same Beta taipoxin obtained the taipoxin component of the venom of the taipan snake, Oxyuranus s. scutellatus, was fragmented by trypsin digestion. The fragment which showed the highest activity on skin cells for mitogenic activity and on PC12 cells for neurite gr... | 10/31/2006 |
| 7118746 | Conditioned cell culture medium compositions and methods of use Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic c... | 10/10/2006 |
| 7109003 | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, ... | 09/19/2006 |
| 7098309 | Recombinant hepatitis B surface antigen The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts... | 08/29/2006 |
| 7094400 | Transkaryotic implantation The present invention provides a method of altering the concentration or level of expression of a desired gene product in a recipient subject which involves administering to a recipient a transkaryotic cell capable of expressing a desired gene when the cell is prese... | 08/22/2006 |
| 7029879 | Iodine uptake restoration in thyroid cancer A method of expressing a tumor specific therapeutic response element in a cancerous cell is disclosed in which the response element was previously blocked from expression. The method comprises the step of administering an unblocking agent to the cancerous cell harbo... | 04/18/2006 |
| 7009043 | Plus end-directed microtubule motor required for chromosome congression The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators. ... | 03/07/2006 |
