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| Number | Title | Issue Date |
| 7442517 | Method for the detection of serovar Described herein is the identification of a novel Salmonella enterica serovar Enteritidis locus that serves as a marker for DNA-based identification of this bacterium. In addition, three primer pairs derived from this locus that may be used in a nucleo... | 10/28/2008 |
| 7270969 | Methods of constructing and screening diverse expression libraries The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the lib... | 09/18/2007 |
| 7255851 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 08/14/2007 |
| 7223534 | Diffraction-based diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ... | 05/29/2007 |
| 7217536 | Medium and method for detecting/identifying microorganisms A medium for biological analysis by biochemical means involving chromogenic or fluorogenic substrates that react with enzymes (esterases and/or osidases and/or peptidases and/or sulfatases and/or phosphatases) specific for the target strains is that is in a stable, ... | 05/15/2007 |
| 7208286 | Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably incorporated into the chromosome of the microorganism and an Optical Applicati... | 04/24/2007 |
| 7198774 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 04/03/2007 |
| 7179603 | Detection and identification of enteric bacteria The invention provides probes, antibodies and methods for detecting a gene that is only found in Enterobacteriaceae, the deoxyguanosine triphosphate triphosphohydrolase gene. These probes and methods are useful for the detecting whether test samples, including food ... | 02/20/2007 |
| 7094464 | Multi-layer coated porous materials and methods of making the same Multi-layer coated materials and methods of making them are disclosed. In a specific embodiment, a porous polymeric substrate is pre-activated and immersed in a polyelectrolyte solution to form a first layer having an electric charge and at least one functional grou... | 08/22/2006 |
| 6962696 | Compositions and methods for tumor-targeted delivery of effector molecules The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor. The primary effector molecule(s) of the invention is used in the method... | 11/08/2005 |
| 6958219 | Method for detecting a gram-negative bacterial autoinducer molecule The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals t... | 10/25/2005 |
| 6905691 | Vaccines containing attenuated bacteria The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations were initially identified as being useful in vaccines from a bank of ran... | 06/14/2005 |
| 6881549 | Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces The present invention provides a method for immobilizing a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (—C(═O)—COOH) or a ketal or hemiketal group corresponding thereto, e.g. derived from KDO (2-keto-3-deoxy-D-manno-... | 04/19/2005 |
| 6866847 | Method of delivering a protein to poultry A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that contains a recombinant gene encoding the protein. ... | 03/15/2005 |
| 6858398 | Saliva test for detection of food allergy and intolerance A method for determining the presence of food allergy or food intolerance and their cross-reactive tissue antigens is disclosed. The method includes determining a level of antibodies against a dietary antigen in a mucosal sample from the patient and comparing the le... | 02/22/2005 |
| 6858439 | Compositions and methods for separation of moieties on chips The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in... | 02/22/2005 |
| 6818409 | Isolation and purification of Clostridium botulinum toxins A method for separating and purifying HA-positive progenitor toxin(s) (LL and/or L toxins) and HA-negative progenitor toxin (M toxin) from a Clostridium botulinum strain is provided. The method comprises applying a liquid containing both the HA-positive proge... | 11/16/2004 |
| 6815172 | Methods and compositions for opsonophagocytic assays Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneou... | 11/09/2004 |
| 6794153 | Helicobacter pylori antigens in blood The present invention relates to the finding and detection of Helicobacter pylori (H. pylori) antigens in blood of infected individuals. The H. pylori antigens are components of H. pylori cells which include, but not limited to DNA, RNA, ... | 09/21/2004 |
| 6713073 | Method of vaccination of newly hatched poultry A method of vaccinating poultry by spraying the poultry with an effective amount of a live avirulent derivative of an enteropathogenic enterobacteria is disclosed. ... | 03/30/2004 |
| 6689569 | Saliva test for detection of food allergy, candidiasis, microflora imbalance, intestinal barrier dysfunction and humoral immunodeficiencies A method for determining a cause for digestive and immune disorders is disclosed. The method determines the levels of antibodies against normal intestinal microflora and food antigens. It then compares the results to normal levels to determine the cause. ... | 02/10/2004 |
| 6649143 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal model... | 11/18/2003 |
| 6630355 | Magnetic focusing immunosensor for the detection of pathogens A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and mea... | 10/07/2003 |
| 6566508 | Fluorogenic compounds and uses therefor Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar... | 05/20/2003 |
| 6509166 | Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction The presence or absence of a target microbial analyte in a substance, such as a biological or environmental substance, is assayed by inoculating a sterile growth media with a sample of the substance. The media may be combined with a labeled analyte-specif... | 01/21/2003 |
| 6495334 | Recombinant Sef14 fimbrial protein from Salmonella A truncated SE fimbria antigen useful as an antigen for immunoassay diagnosis of Salmonella enteritidis (SE) infection or evidence of infection.... | 12/17/2002 |
| 6436653 | Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces The present invention provides a method for immobilizing a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (--C(.dbd.O)--COOH) or a ketal or hemiketal group corresponding thereto, e.g. derived from KDO (2-keto-3-deo... | 08/20/2002 |
| 6391653 | Acoustic standing-wave enhancement of a fiber-optic salmonella biosensor A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be conce... | 05/21/2002 |
| 6379918 | Composition, formulae, devices and methods for control of specificity and inclusivity of microorganisms containing closely related antigen epitopes Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or similar detection technology, wherein detection requires th... | 04/30/2002 |
| 6348318 | Methods for concentrating ligands using magnetic particles This invention provides methods, compositions and kits for concentrating target ligands, including microorganisms, from samples, including biological samples. The methods involve the use of magnetic particles to concentrate the target analytes. Also provi... | 02/19/2002 |
| 6217847 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for tracking light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models... | 04/17/2001 |
| 6203996 | Rapid detection of bacteria liquid cultures A means for the rapid detection of bacteria from a liquid culture or slurry is described. A membrane mounted on a solid support is immersed in a liquid culture for a time sufficient to allow bacteria to adhere to the membrane, the membrane is removed from... | 03/20/2001 |
| 6159689 | Methods of capture and assay procedures Methods of capturing and labeling a species, include attracting magnetically attractable particles to a solid support by magnetic forces, which particles have an affinity for the species, contacting the particles on the support with a sample containing th... | 12/12/2000 |
| 6004766 | Method for detecting low levels of microorganisms A method is provided for the detection of low levels of a microorganism in a sample in the presence of competing microflora, comprising the steps of: (a) exposing the sample to a solid support to which are adsorbed antibodies specific for said microorgani... | 12/21/1999 |
| 5989841 | Polypeptides and nucleic acids derived from Salmonella typhi and detection of Salmonella using thereof Nucleic sequences from the genome of Salmonella Typhi include all or part of the genetic information required for the in vitro infection of cultured HeLa cells by Salmonella bacteria. Polypeptides encoded by these nucleic sequences are also described, as ... | 11/23/1999 |
| 5965458 | Test strip, its production and use A test strip for a rapid immunoassay containing specific immunochemical reagent zones (7, 8, 9) is described. The test strip (10) has a backing sheet (1) and attached thereto a receiving end pad (3) and at a distance therefrom a finishing end pad (5). A t... | 10/12/1999 |
| 5935799 | Biological assay for microbial contamination A semi-quantitative method for determining the concentration of viable coliforms or E. coli in a liquid is provided. The sample to be tested is mixed with an indicator reagent which includes a specific indicator compound that undergoes a change that is de... | 08/10/1999 |
| 5902722 | Method of detecting organisms in a sample The presence or absence of an organism in a sample is detected by isolating the organism from the sample by a suitable affinity matrix, releasing the organism from the affinity matrix, rupturing the cells of the organism to release total nucleic acid and ... | 05/11/1999 |
| 5871944 | Salmonellae preferential media A new Salmonella preferential media uses lactose and cellobiose to suppress formation of black colonies by non-Salmonella, to permit easy inspection of the media to determine the presence or absence of Salmonella. Modified media, including high levels of ... | 02/16/1999 |
| 5840509 | Protease and related nucleic acid compounds The present invention provides for a novel ICE related protease and nucleic acids coding same. The present invention also provides a method to isolate an ICE related protease and related DNA compounds encoding this protease. The present invention further ... | 11/24/1998 |
