Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7399602 | Method of prognosticating respiratory bacterial infection using urokinse receptor measurement Method of diagnosing and/or prognosticating HIV infection in a subject comprising the steps of: (a) performing in vitro a measurement of the level of a marker in the form of (i) urokinase plasminogen activator receptor (uPAR), (ii) soluble urokinase plasminogen acti... | 07/15/2008 |
| 7358076 | Sublancin lantibiotic produced by 168 An antimicrobial peptide produced by Bacillus subtilis 168 was isolated and characterized and named sublancin 168. The invention includes DNA encoding for the sublancin 168 peptides and peptides which are at least 80% identical to the sublancin 168 peptide. T... | 04/15/2008 |
| 7323340 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 01/29/2008 |
| 7319046 | Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles An integrated optoelectronic silicon biosensor that can detect biomolecules by the change of the optical coupling between the integrated light source and the integrated detector that is caused by the binding of the appropriately labeled analytes onto the recognition... | 01/15/2008 |
| 7316910 | Rapid test for hemolytic streptococcus A reagent for the detection of an extracellular enzymatically active protein produced by a beta-hemolytic streptococcus bacteria found in a host biological fluid includes a proteinaceous substrate or a cholesterol-containing membrane substrate for the extracellular ... | 01/08/2008 |
| 7291343 | antigens and vaccines A majority of E. faecalis and E. faecium clinical isolates fall into two groups and three groups, respectively. Distinct antigens are associate with each of the five groups. The Enterococcus antigens are readily obtained from strains of E. fa... | 11/06/2007 |
| 7285246 | Hand-held fluid analyzer A hand-held device detects the presence of a preselected substance in the breath. A deformable housing forms a test chamber for interacting an indicator reagent with the breath. An ampoule positioned inside the housing is ruptured by manual pressure through the wall... | 10/23/2007 |
| 7270969 | Methods of constructing and screening diverse expression libraries The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the lib... | 09/18/2007 |
| 7258992 | Immunization of dairy cattle with chimeric GapC protein against infection The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Str... | 08/21/2007 |
| 7252646 | Universal connecting device that designates an operational mode A controller for a gradient sequential compression system is provided for inflating a plurality of inflatable chambers of one or more compression sleeves according to several different modes of operation. A mode of operation may define the number and selection of ch... | 08/07/2007 |
| 7223534 | Diffraction-based diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ... | 05/29/2007 |
| 7189810 | Polypeptides, use thereof and process for producing the same An isolated polypeptide comprises the amino acid sequence of SEQ ID NO: 11, wherein the expression of said polypeptide is significant lower specifically in human livers with hepatitis compared with that in human health livers. The detection of said polypeptide expre... | 03/13/2007 |
| 7169550 | Diffraction-based diagnostic devices A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive mater... | 01/30/2007 |
| 7160689 | Pretreatment instrument of saliva and pretreatment method of saliva In a pretreatment instrument and a pretreatment method of saliva, used for identification and quantitation of Streptococcus mutans in saliva by the immunochromatographic method utilizing an antigen-antibody reaction, the instrument includes a swab and a mixin... | 01/09/2007 |
| 7141418 | polynucleotides and sequences The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides,... | 11/28/2006 |
| 7122194 | Vaccine compositions comprising polypeptides having selected structural motifs A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie between 80 and 680 residues in length. Also disclosed are processes f... | 10/17/2006 |
| 7097808 | Automatic analyzer An automatic analyzer analyzes a measurement item by making a sample and reagent react with each other and measuring the reaction result. This apparatus allows parameters associated with reagent dispensing executed by a reagent dispensing mechanism to be set as a di... | 08/29/2006 |
| 7091049 | Enhanced diffraction-based biosensor devices An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance with the analyte of interest, the tag emitting a measurable paramete... | 08/15/2006 |
| 7083912 | MAb-based Dot-ELISA method and assay kit for the detection of viruses A monoclonal antibody-based Dot-ELISA assay for the rapid detection of animal viruses such as avian influenza virus. The assay includes applying a specimen suspected of containing an animal virus on a porous membrane and treating the specimen with a solution of citr... | 08/01/2006 |
| 7078061 | Methods, compositions and kits for biomarker extraction The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods, kits, reagents and compositions for measuring a plurality of different ... | 07/18/2006 |
| 7078042 | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least o... | 07/18/2006 |
| 7056510 | Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. An... | 06/06/2006 |
| 7052831 | Detection of multiple analytes from a single sample using a multi-well, multi-analyte flow-through diagnostic test device The present invention provides a method and device for conducting a rapid in vitro enzyme immunoassay test for the direct and qualitative detection of two or more viral antigens from specimens of symptomatic patients. The method for immunoassay of viral antigens is ... | 05/30/2006 |
| 7049419 | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least o... | 05/23/2006 |
| 7033613 | Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino ... | 04/25/2006 |
| 6979576 | Methods of use of one step immunochromatographic device for Streptococcus A antigen A method to determine the presence or absence of Streptococcus Group A antigen in a sample, comprising the following steps: extracting the antigen from the sample in an assay chamber with two or less extraction reagents, wherein the two reagents may be added to the ... | 12/27/2005 |
| 6974700 | Kit for use in predicting refractory periodontal disease A kit and method of predicting a refractory response in a subject diagnosed as having periodontal disease by measuring serum concentrations of actinomyces antibodies, streptococcal antibodies and lysine decarboxylase antibodies and using the measurement along with o... | 12/13/2005 |
| 6936422 | Polynucleotides and their use for detecting resistance to streptogramin A or to streptogramin B and related compounds The present invention pertains to polynucleotides derived from staphylococcal genes encoding resistance to streptogramin A or to streptogramin B and chemically related compounds. This invention also relates to the use of the polynucleotides as oligonucleotide... | 08/30/2005 |
| 6936259 | CAMP factor of Streptococcus uberis The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial speci... | 08/30/2005 |
| 6927062 | Controls and standards for assays and method for manufacture thereof Controls and standards for assays and method for manufacturing the controls and standards is described. The controls or standards comprise a porous carrier material which has quantitatively reversibly absorbed and dried thereon an analyte for the control or standard... | 08/09/2005 |
| 6908619 | Camp factor of streptococcus uberis The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections. ... | 06/21/2005 |
| 6858439 | Compositions and methods for separation of moieties on chips The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in... | 02/22/2005 |
| 6858398 | Saliva test for detection of food allergy and intolerance A method for determining the presence of food allergy or food intolerance and their cross-reactive tissue antigens is disclosed. The method includes determining a level of antibodies against a dietary antigen in a mucosal sample from the patient and comparing the le... | 02/22/2005 |
| 6835818 | Mutants of Streptococcal toxin C and methods of use This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-l... | 12/28/2004 |
| 6824997 | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is conjugated to a spacer molecule, and the free end of the latter is then c... | 11/30/2004 |
| 6815172 | Methods and compositions for opsonophagocytic assays Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneou... | 11/09/2004 |
| 6774218 | Mutants of streptococcal toxin C and methods of use This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-l... | 08/10/2004 |
| 6756361 | Enterococcus antigens and vaccines A majority of E. faecalis and E. faecium clinical isolates fall into two groups and three groups, respectively. Distinct antigens are associate with each of the five groups. The Enterococcus antigens are readily obtained from strains of E. faecalis ... | 06/29/2004 |
| 6720160 | Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals The present invention involves a method and an immuno-analytical device for the rapid and simultaneous detection of multiple micro-organisms in the biological fluids from milk-producing animals suffering from mastitis. This method is based on a lateral flow immuno-a... | 04/13/2004 |
| 6689569 | Saliva test for detection of food allergy, candidiasis, microflora imbalance, intestinal barrier dysfunction and humoral immunodeficiencies A method for determining a cause for digestive and immune disorders is disclosed. The method determines the levels of antibodies against normal intestinal microflora and food antigens. It then compares the results to normal levels to determine the cause. ... | 02/10/2004 |
