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Class 435/7.33 - Staphylococcus


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter involving bacteria of the genus Staphylococcus.
No. of patents: 87
Last issue date: 07/15/2008


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NumberTitleIssue Date
7399609/patents/7399609/description.html
The invention relates to methods of detecting staphylococcus. ...
07/15/2008
7364918Colorimetric sensors constructed of diacetylene materials
Colorimetric sensors comprising a receptor incorporated within polydiacetylene assemblies to form a transducer capable of indicating a color change when contacted with an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric ...
04/29/2008
7358076Sublancin lantibiotic produced by 168
An antimicrobial peptide produced by Bacillus subtilis 168 was isolated and characterized and named sublancin 168. The invention includes DNA encoding for the sublancin 168 peptides and peptides which are at least 80% identical to the sublancin 168 peptide. T...
04/15/2008
7279162Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection
The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further describes an in vivo animal model useful for testing the efficacy of phar...
10/09/2007
7270969Methods of constructing and screening diverse expression libraries
The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the lib...
09/18/2007
7234414Mastitis detection
Method and apparatus for testing a milk for mastitis wherein the milk sample is admixed with a detergent under condition that increase the viscosity of the milk sample; the increased viscosity mixture is subjected to a further procedure for further increasing its vi...
06/26/2007
7223534Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ...
05/29/2007
7045131Staphylococcal immunotherapeutics via donor selection and donor stimulation
A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a d...
05/16/2006
7015007Capsular polysaccharide adhesin antigen, preparation, purification and use
A substantially pure capsular exopolysaccharide adhesin of coagulase-negative staphylococcal strains, and a gonoral method to prepare such adhesins, are described. Vaccines composed of such adhesins, and uses of such adhesins to produce polyclonal and monoclonal ant...
03/21/2006
7005510Recombinant DNase B derived from
The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing l...
02/28/2006
6979446Monoclonal antibodies to the ClfA protein and method of use in treating or preventing infections
Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from Staphylococcus aureus, including the active fragments proteins from its fibrinogen binding domain such as Clf...
12/27/2005
6936258Staphylococcus antigen and vaccine
A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus
08/30/2005
6858439Compositions and methods for separation of moieties on chips
The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in...
02/22/2005
6858398Saliva test for detection of food allergy and intolerance
A method for determining the presence of food allergy or food intolerance and their cross-reactive tissue antigens is disclosed. The method includes determining a level of antibodies against a dietary antigen in a mucosal sample from the patient and comparing the le...
02/22/2005
6815172Methods and compositions for opsonophagocytic assays
Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneou...
11/09/2004
6790448Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface protein...
09/14/2004
6783930Development of novel anti-microbial agents based on bacteriophage genomics
A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for p...
08/31/2004
6767536Recombinant Staphylococcus thioredoxin reductase and inhibitors thereof useful as antimicrobial agents
Isolated and purified Staphylococcus thioredoxin reductases (TrxB) are provided. Polynucleotides encoding the TrxBs, vectors and host cells containing such polynucleotides are also provided. In addition, antibodies reactive with the TrxBs are provided, as are method...
07/27/2004
6747129Target of RNAIII activating protein(TRAP)
The present invention is directed to a protein isolated from S. aureus that is the target of RAP, called TRAP, which is characterized by a molecular weight of about 21 KDa, is capable of being phosphorylated by RAP, and comprises an amino acid sequence of SEQ...
06/08/2004
6740485Anti-bacterial methods and materials
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and provision of novel S. aureus mutants useful in vaccines. ...
05/25/2004
6720160Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals
The present invention involves a method and an immuno-analytical device for the rapid and simultaneous detection of multiple micro-organisms in the biological fluids from milk-producing animals suffering from mastitis. This method is based on a lateral flow immuno-a...
04/13/2004
6713250Identification of human allergens and T-lymphocyte antigens in vitro
The invention provides a method for screening a test compound for the ability of the test compound to induce a response from human naive T-cells. The method comprises admixing human naive T cells, macrophages/monocytes, immortalized B cells lacking class I and class...
03/30/2004
6689569Saliva test for detection of food allergy, candidiasis, microflora imbalance, intestinal barrier dysfunction and humoral immunodeficiencies
A method for determining a cause for digestive and immune disorders is disclosed. The method determines the levels of antibodies against normal intestinal microflora and food antigens. It then compares the results to normal levels to determine the cause. ...
02/10/2004
6686169Reagent for the detection of Staphylococcus aureus by agglutination
Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Stap...
02/03/2004
6630355Magnetic focusing immunosensor for the detection of pathogens
A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and mea...
10/07/2003
6566508Fluorogenic compounds and uses therefor
Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar...
05/20/2003
6528272Receptor-based assays for pathogens
A rapid, simple, and inexpensive sandwich enzyme-linked receptor based immunodot assay detects pathogens or pathogenic products in test samples using receptors for a characteristic component of the pathogen. This assay is widely applicable because it is h...
03/04/2003
6485899Anti-bacterial methods and materials
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel S. aureus mutants useful in vaccines....
11/26/2002
6482602Reagent for the detection of Staphylococcus aureus by agglutination
Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Stap...
11/19/2002
6475788Anti-bacterial antibodies and methods of use
A process of preparing a pharmaceutical composition includes the steps of: a) obtaining isolated immunoglobulins from an animal; b) contacting the isolated immunoglobulins with a bacterial Fc-binding protein; c) collecting the immunoglobulins not bound to...
11/05/2002
6410696Cyclosporin immunoassay
A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring the amount of cyclosporin in a sample suspected of contain...
06/25/2002
6340571Antibodies specific for Staphylococcus aureus, and use thereof
A monoclonal or polyclonal antibody specific for an epitope common to Staphylococcus aureus strains of various capsular serotypes, particularly methicillin-resistant strains, the antibody being selected from immunoglobulins G, M, and A, and the use thereo...
01/22/2002
6316211ThdF
The invention provides thdF polynucleotides encoding thdF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing thdF polypeptides to screen for antibacterial compounds....
11/13/2001
6228602Competitive apo-peroxidase assay
Disclosed is an assay for an analyte in a fluid test sample such as urine which involves combining the fluid test sample with a reagent system comprising an apo-peroxidase, a redox dye, a peroxide and a metal porphyrin which is bound to an analyte/analyte...
05/08/2001
6165740Method and device for flow-cytometric microorganism analysis
To reduce the effects of the contaminants in the measurement of microorganisms and the reduction of the time necessary for the measurement. Measurement is performed of the microorganism prior to and following culture, and the difference between the two is...
12/26/2000
6156524Reagent for the detection of Staphylococcus aureus by agglutination
Reagents and methods for the detection of Staphylococcus aureus are provided. The reagents contain an antibody that binds to a capsular polysaccharide of type 5 of Staphylococcus aureus, and can be used in methods for detection of oxacillin resistant Stap...
12/05/2000
6143868Monofunctional glycosyltransferase of Staphylococcus aureus
The invention provides isolated nucleic acid compounds encoding a novel MTG of Staphylococcus aureus. Also provided are vectors and transformed heterologous host cells for expressing the MTG and a method for identifying compounds that bind and/or inhibit ...
11/07/2000
5998128Use of porphyrins in instrumental detection methods
The present invention relates to a process for quantifying entities, comprising the steps of (a) mixing an effective detection amount of a (proto-) porphyrin represented by formula (I) ##STR1## wherein R1 independently represents a radical...
12/07/1999
5955074Directed human immune globulin for the prevention and treatment of staphylococcal infections
This invention is directed to a Directed Human Immoglobulin and compositions thereof for preventing or treating staphylococcal infections such as S. epidermidis in neonates....
09/21/1999
5922549Process for screening substances having a modulating effect on an interleukin-5 receptor mediated cellular signal transmission pathway
A process is disclosed for screening substances having a modulating effect on the interleukine-5-receptor-dependent signal tranmission path in mammal cells. Test substances are applied on cells which express the functional interleukine-5-receptor and are ...
07/13/1999
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