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...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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| Number | Title | Issue Date |
| 8133691 | Stable quantitation and detection of immune response levels with non-zero background peptides The invention relates to a kit comprising MHC Class I and Class II HLA-coated beads containing specific antigenic peptides for binding to antigen-specific T cells and the appropriate negative control peptides. Also provided are methods for making the coated beads an... | 03/13/2012 |
| 8105797 | Diagnostic test The invention provides a method of diagnosing Mycobacterium tuberculosis infection in a human, or of determining whether a human has been exposed to Mycobacterium tuberculosis, comprising: (i) contacting T-cells from said human with one or more of (a) ... | 01/31/2012 |
| 8097430 | Antigen targeting The present invention provides a method of raising an immune response in an animal. The method comprises administering to the animal a composition comprising a carrier and an antigen bound to a targeting moiety wherein the targeting moiety binds to at least one rece... | 01/17/2012 |
| 8071325 | Flow cytometric method and kit for metal-induced sensitivity This invention provides methods for determining metal-induced sensitivity of a subject and kits for affecting the same. Specifically, the invention provides methods for using immune cell proliferation resulting from exposure to test metals as a method for determinin... | 12/06/2011 |
| 8067191 | Method for detecting IL-16 activity and modulation of IL-16 activity based on rantes proxy protein levels Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of or susceptibility of a subject to an IL-16-related disorder involve measuring and comparing the levels of RANTES proxy produced by euka... | 11/29/2011 |
| 8058021 | Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene.... | 11/15/2011 |
| 8026076 | IP-10 based immunological monitoring The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10. The invention further discloses an assay and a kit for measuring CMI to an anti... | 09/27/2011 |
| 7998696 | Cell assay kit and method A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a... | 08/16/2011 |
| 7993864 | Assay for identifying antibody producing cells The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody produci... | 08/09/2011 |
| 7977063 | Method for determining an allergic response The present invention concerns a method for determining an allergic response by determining the extent of degranulation of human IgE sensitized cells upon activation by allergens in food products. ... | 07/12/2011 |
| 7972804 | Methods of detecting antibodies specific for denatured HLA antigens The invention is directed to methods of screening for HLA antibodies comprising detecting antibodies specific for native HLA antigens and denatured HLA antigens. The invention also provides for method of predicting whether a transplant recipient has an increased ris... | 07/05/2011 |
| 7968308 | Isolating human antibodies The invention is drawn to a method of isolating human antibodies. ... | 06/28/2011 |
| 7960131 | Functional genomic pore assay for mixed cell populations A method of assaying nucleotide receptor P2X7 pore activity in white blood cells contained within a mixed cell sample is provided comprising labeling white blood cells with a white blood cell-specific label; depolarizing the labeled white blood cells with... | 06/14/2011 |
| 7947464 | Method for identifying regulatory T cells The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious... | 05/24/2011 |
| 7923215 | Process for the measurement of the potency of glatiramer acetate The subject invention provides a process for measuring the relative potency of a test batch of glatiramer acetate. In addition, the subject invention provides a process for preparing a batch of glatiramer acetate as acceptable for pharmaceutical use. ... | 04/12/2011 |
| 7919265 | Antibody-based method for isolating Th1 and Th2 helper lymphocytes from human peripheral blood A negative isolation method for separately isolating preparations of Th1 and Th2 helper lymphocytes from peripheral blood mononuclear cells involving the use of novel combinations of monoclonal antibodies to separately sequester specific Th1 and Th2 lymphocytes and ... | 04/05/2011 |
| 7879571 | Population based assessments and means to rank the relative immunogenicity of proteins The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations wherein the immune response directed against any protein of i... | 02/01/2011 |
| 7829302 | Method for detecting the specificity of activated lymphocyte A method for detecting the specificity of activated lymphocytes is provided. The present method can be used to detect the specificity of activated lymphocytes in recipients or patients after organ transplantation or being infected by pathogenic microorganism or vacc... | 11/09/2010 |
| 7824873 | Blood test kit A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to permeate through, while agglutinated red blood cells cannot. The apparatus a... | 11/02/2010 |
| 7803566 | Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8+ T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been ide... | 09/28/2010 |
| 7803565 | Use of lymphocytes to measure anthrax lethal toxin activity It is disclosed herein that isolated lymphocytes, such as human B-cells and CD4+ T-cell can be used to determine an amount of lymphocyte-associated anthrax lethal toxin activity present. Methods of using isolated lymphocytes to identify anthrax therapeuti... | 09/28/2010 |
| 7785818 | Inflammatory bowel disease and irritable bowel syndrome IBD-first chek diagnostic panel A method for the differentiation of inflammatory bowel disease (IBD) from irritable bowel disease (IBS) followed by distinguishing ulcerative colitis and Crohn's disease from other gastrointestinal illnesses. This highly differential method first uses the presence o... | 08/31/2010 |
| 7745157 | Human lymphocyte medium adjuvant The present invention relates to an adjuvant derived from human lymphocytes. The adjuvant can be used in combination with traditional vaccines or cancer immunotherapy, to enhance the response of the patient's immune system to the vaccine or other immunotherapeutic a... | 06/29/2010 |
| 7718575 | Method of selecting HLA-DP4 ligands and the applications thereof A method of selecting a test molecule that binds to HLA-DP4 by (i) incubating HLA-DP4 with the test molecule and a labeled peptide of formula (I) Z1X1X2X3X4X5X6X7X8X | 05/18/2010 |
| 7713714 | Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof A method for inducing proliferation of cytolytic T cells is described. ... | 05/11/2010 |
| 7674598 | Method for a fully automated monoclonal antibody-based extended differential Methods for differentially identifying cells in an instrument employ compositions containing a combination of selected antibodies and fluorescent dyes having different cellular distribution patterns and specificities, as well as antibodies and fluorescent dyes chara... | 03/09/2010 |
| 7670793 | Enumeration of CD4+ lymphocytes The invention provides a method of enumerating the number of cells of a cell type in a cell sample by (a) counting the white blood cells in the cell sample to obtain the white blood cell population of the sample; (b) determining the proportion or percentage of the c... | 03/02/2010 |
| 7659084 | Methods for detecting and isolating antigen-specific T lymphocytes with CD40/C154 inhibitors What is suggested herein is the use of CD154 for the detection and/or isolation of antigen-specific T lymphocytes and a method for the detection and/or isolation of antigen-specific T lymphocytes, wherein the suspension is contacted with a CD40/CD154 system inhibito... | 02/09/2010 |
| 7604955 | Immunoglobulin E vaccines and methods of use thereof The present invention concerns the prophylaxis or therapy of immunoglobulin E-mediated disease conditions. The present invention discloses methods for identifying peptides that induce a cytotoxic T-lymphocyte response against immunoglobulin E. The present invention ... | 10/20/2009 |
| 7588905 | Identification and monitoring of systemic lupus erythematosus A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE and/or... | 09/15/2009 |
| 7585640 | Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells. ... | 09/08/2009 |
| 7560243 | White blood cell functional assay A method of rapidly assaying nucleotide receptor P2X7 pore activity in white blood cells contained within a blood sample. A method according to the invention includes the steps of: (a) labeling the white blood cells with a white blood cell-specific label;... | 07/14/2009 |
| 7527938 | Methods for diagnosis and treatment of chronic immune diseases Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the pres... | 05/05/2009 |
| 7524641 | Method of separating cells from a sample Rare cells are separated from a sample fluid by a positive selection or negative selection antibody by centrifuging in a tube containing a harvesting float. The harvesting float has an axial passage and a density to settle in the sample fluid and expand the layer of... | 04/28/2009 |
| 7521197 | Method for producing cytotoxic T-cells The invention relates to the method for producing antipeptide cytotoxic T lymphocytes (CTLs) by attaching a complex of a class I HLA and a peptide to antigen presenting cell(s) (APCs) present in a sample of peripheral blood lymphocytes (PBLs), optionally removing ex... | 04/21/2009 |
| 7521198 | Compositions and methods for detecting and treating atherosclerosis Methods for detecting atherosclerotic plaque and quantifying the amount of Group V sPLA2 in plasma are disclosed. These methods can be used to assess the risk of cardiovascular pathology in a patient. ... | 04/21/2009 |
| 7514232 | Method for detecting T cell response to specific antigens in whole blood This invention comprises a novel approach to the assessment of antigen-specific T cells that quantitates and characterizes these cells with unprecedented clarity, and importantly, because it is performed in whole blood, is amenable to routine use in the clinical imm... | 04/07/2009 |
| 7504228 | Integrin linked kinase modulation of monocyte activation Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expres... | 03/17/2009 |
| 7476514 | Method for monitoring the immune response and predicting clinical outcomes in transplant recipients Methods for monitoring the immune response and predicting clinical outcomes for patients on immunosuppressive drugs (such as transplant patients) are provided. The methods are based on the measurement of an intracellular metabolic marker in lymphocytes (such as ATP)... | 01/13/2009 |
| 7465555 | Early detection of sepsis Diagnostic methods, systems, and kits for identifying patients with systemic inflammatory response syndrome who are likely to progress to sepsis. ... | 12/16/2008 |
