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| Number | Title | Issue Date |
| 8187824 | Porphyrinic compounds for use in flow cytometry The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compoun... | 05/29/2012 |
| 8187825 | Thiol detection method It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due to hydrolysis; and a method for detecting thiol using the aforementio... | 05/29/2012 |
| 8173381 | Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic... | 05/08/2012 |
| 8168586 | Cancer targets and uses thereof Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for thes... | 05/01/2012 |
| 8168404 | Methods to treat cancer with 10-propargyl-10-deazaaminopterin and methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin The present invention relates to a method for assessing the sensitivity of a patient's cancer to treatment with 10-propargyl-10-deazaminopterin and a method for selecting a patient for treatment of cancer with 10-propargyl-10-deazaminopterin, by determining the amou... | 05/01/2012 |
| 8163510 | Quantitative ZAP-70 assay An quantitative ZAP-70 assay is provided, with ZAP-70+ and ZAP-70− controls, normal human blood controls, an improved antibody with better signal to noise ratio, and using the median MEFL that is calibrated using a standard curve. ... | 04/24/2012 |
| 8163509 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor,... | 04/24/2012 |
| 8158373 | Method of detecting cancer and evaluating cancer prognosis A method of detecting cancer in a subject is provided. One step of the method includes obtaining a bodily sample from the subject. Next, the level of pro-prion protein (pro-PrP) in the bodily sample is detected. The level of pro-PrP in the bodily sample is then comp... | 04/17/2012 |
| 8148093 | Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk This invention relates to a method for assessing risk of prostate cancer. Specifically, it relates to utilizing both Pro108 and Prostate Specific Antigen (PSA) in combination to determine the risk of prostate cancer. In addition, it is directed to a method for asses... | 04/03/2012 |
| 8148094 | Methods and compositions for detecting the activation state of multiple proteins in single cells The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of co... | 04/03/2012 |
| 8129114 | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators EGFR biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) measuring in the mammal the level of at least... | 03/06/2012 |
| 8129131 | Pin1 as a marker for abnormal cell growth Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating... | 03/06/2012 |
| 8110373 | Methods and compositions for treating and diagnosing diseases Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT,... | 02/07/2012 |
| 8105796 | Regulation of expression of PI3Kβ protein in tumors We describe the use of PI3Kβ protein and/or its encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers, as well as a method for the diagnosis of malignant cell growth comprising the measuring the expression of P... | 01/31/2012 |
| 8101371 | Methods for the diagnosis of genitourinary cancer Methods for the diagnosis of genitourinary (GU) cancer are provided. In particular, urine has been found to contain significant levels of thromboxane receptor β (TPβ) methods for diagnosing GU cancer. Methods for assessing treatment, prognosing and staging GU canc... | 01/24/2012 |
| 8101370 | Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequ... | 01/24/2012 |
| 8101372 | Diagnosis and therapy of cancer using SGP28-related molecules The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable ... | 01/24/2012 |
| 8097429 | Method for characterization of abnormal cells It is described a method to detect and phenotype target cells in cell suspensions by using particles coated with antibodies/ligands directed to antigenic determinants/receptors expressed on the target cells, characterized in that several types of particles, each par... | 01/17/2012 |
| 8093013 | Claudins as markers for early detection, diagnosis, prognosis and as targets of therapy for breast and metastatic brain or bone cancer Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue ... | 01/10/2012 |
| 8093012 | Multiplex in situ immunohistochemical analysis A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear antigens, in a tissue sample. ... | 01/10/2012 |
| 8093011 | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase... | 01/10/2012 |
| 8088590 | Use of FOXC2 in diagnosing, preventing and treating cancer metastasis The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, o... | 01/03/2012 |
| 8088591 | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described. ... | 01/03/2012 |
| 8080384 | Method for determination of prognosis of prostate cancer, and diagnostic agent for use in the method A method for determining probability that prostate cancer will metastasize, as well as a diagnostic reagent used therefor is disclosed. It was discovered that the percentage that NF-κB-p65/RelA has the 254th amino acid threonine which is phosphorylated is significa... | 12/20/2011 |
| 8076094 | Phosphorylation of histone H3 at threonine 11—a novel epigenetic mark for transcriptional regulation The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least on... | 12/13/2011 |
| 8076093 | Monoclonal antibodies and methods for their use in the detection of cervical disease Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding c... | 12/13/2011 |
| 8071324 | Methods for diagnosing and treating kidney cancer Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detec... | 12/06/2011 |
| 8071321 | Methods for up-regulating antigen expression in tumors The invention provides methods of modulating tumor antigen associated (TAA) expression, and methods of modulating TAA expression in order to treat a tumor. More particularly, the invention provides methods of increasing an immune response against a tumor cell. Metho... | 12/06/2011 |
| 8071323 | Human monoclonal antibodies that bind human insulin like growth factors and their use Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided. ... | 12/06/2011 |
| 8071322 | Method for identifying differentially expressed proteins The invention provides a method of identifying an antigen that is present in different amounts in two different samples. In general, the methods involve generating a first and second distinguishably labeled population of antibodies that reactive to the two samples, ... | 12/06/2011 |
| 8067190 | Use of protein SATB2 as a marker for colorectal cancer The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type. ... | 11/29/2011 |
| 8067189 | Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators by measuring the level of collagen type IV VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulato... | 11/29/2011 |
| 8062859 | Method for screening anticancer substances, set or kit for implementing said method A method for screening anticancer substances comprising the following steps: a) obtaining a culture of tumour cells which do not express E-cadherin on their cell membrane; b) bringing the cells obtained at step a) into contact with a candid... | 11/22/2011 |
| 8062858 | Artificial antibody polypeptides A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kit... | 11/22/2011 |
| 8058020 | Method of detecting cancer using delta-catenin The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence... | 11/15/2011 |
| 8034577 | Methods and probes for detecting esophageal cancer Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained fr... | 10/11/2011 |
| 8034578 | oncogene as a prognostic indicator for lung cancer The present invention provides the method of predicting an non-small cell lung cancer (NSCLC) prognosis. ... | 10/11/2011 |
| 8030014 | Detecting agent and therapeutic agent for highly malignant breast cancer A detection agent for high malignancy breast cancer includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. A therapeutic agent for high malignancy breast cancer includes a conjugate of an anticancer drug and an antibody ag... | 10/04/2011 |
| 8030013 | Methods and compositions for the diagnosis for early hepatocellular carcinoma Methods and compositions are provide to allow discrimination of dysplastic nodules from early HCC nodules. More specifically, it has been determined that TERT, GPC3, gankyrin, survivin, TOP2A, LYVE1, Ecadherin, IGFBP3, PDGFRA, TGFA, cyclin D1 and HGF are differentia... | 10/04/2011 |
| 8030012 | Id-1 and Id-2 genes and products as markers of epithelial cancer A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When e... | 10/04/2011 |
