Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 8114618 | Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody,... | 02/14/2012 |
| 8114616 | Methods for diagnosing irritable bowel syndrome The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the detecting antibody. Luminescent substrate CPSD was used to enhance the ... | 02/14/2012 |
| 8114617 | Method for quantifying phosphokinase activity on proteins The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of... | 02/14/2012 |
| 8114615 | Method for automated tissue analysis The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a ... | 02/14/2012 |
| 8110352 | Method of diagnosing and treating cancer using B-catenin splice variants The invention relates to method of diagnosing and treating cancer, in particular β-catenin related cancers. The invention further relates to methods of identifying CTNNB1 related cancer CTNNB1 therapeutics. ... | 02/07/2012 |
| 8105794 | Rapid nasal assay kit The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an allergic reaction or a non-allergic reaction. ... | 01/31/2012 |
| 8101369 | Diagnose device for measuring the ratio of proteins with similar structure The present invention relates to a diagnostic device for measuring the ratio of similar structural proteins among the proteins secreted in a liquid test sample taken from diagnosis subject. In further detail, the test device according to the present invention compri... | 01/24/2012 |
| 8101368 | Quantitation of cellular DNA and cell numbers using element labeling Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental ... | 01/24/2012 |
| 8097426 | Methods of screening T1R2/T1R3 receptors for compounds which modulate sweet taste signaling Heteromeric taste receptors are provided. These receptors comprise a first polypeptide containing extracellular domains and transmembrane domains wherein the extracellular domains are at least 95% identical to the extracellular domains of specific T1R1 polypeptides ... | 01/17/2012 |
| 8097427 | Direct mass spectrometric analysis of drug candidates targeting protein complexes The invention relates to a method of using high mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the qualitative and quantitative analysis of the effect of drug candidates on protein complexes such as protein-protein interactions in pur... | 01/17/2012 |
| 8097428 | Monoclonal antibodies and their use Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifi... | 01/17/2012 |
| 8097425 | Multiplex protein fractionation The invention provides methods, compositions, and kits for multiplex fractionation of proteins in a sample. Protein-binding molecules, such as small epitope antibodies or small epitope aptamers, are used for multiplex fractionation of proteins in a protein containin... | 01/17/2012 |
| 8093010 | Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these molecules can prevent interaction between JAM-B and JAM-C; testing the positi... | 01/10/2012 |
| 8088579 | Complement factor H for diagnosis of age-related macular degeneration The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD. ... | 01/03/2012 |
| 8084222 | Methods for generating host cells The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value. ... | 12/27/2011 |
| 8080383 | Method of discriminating at least two cell populations, and application A subject of the invention is a method for discriminating between and counting at least two populations of biological elements carrying specific characteristics, optionally present in a sample. The invention allows the clear and unambiguous detection of at least thr... | 12/20/2011 |
| 8076090 | Label free biosensors and cells Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed. ... | 12/13/2011 |
| 8076091 | Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed ag... | 12/13/2011 |
| 8076092 | Nonseparation assay methods Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte fr... | 12/13/2011 |
| 8071320 | Use of specific T2R taste receptors to identify compounds that block bitter taste Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with... | 12/06/2011 |
| 8067188 | Analyte detection The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measu... | 11/29/2011 |
| 8067187 | Cross-β structure binding compounds The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structure conformation. Even more particular, the invention relates to compounds capa... | 11/29/2011 |
| 8062857 | H-FABP as early predictor of myocardial infarction The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac troponin level which is detectable but lower than the level that is considered as being indicative for a myocardial... | 11/22/2011 |
| 8062854 | Method for enriching a prokaryotic DNA A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein... | 11/22/2011 |
| 8062855 | Assay methods and materials The invention relates to assays in which complexes between an analyte and a binding agent specific for the analyte are detected by a reporter molecule, which is capable of binding to the binding agent when the binding agent is complexed with analyte but not when the... | 11/22/2011 |
| 8062856 | System for cell-based screening The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large n... | 11/22/2011 |
| 8053204 | Beta-2 microglobulin as a biomarker for peripheral artery disease The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject. ... | 11/08/2011 |
| 8053203 | Methods and device for the detection of occult blood The present invention relates generally to detection of occult blood. In particular, the present invention provides a device and methods for the simultaneous detection of hemoglobin and transferrin in fecal samples, which permit a more sensitive diagnosis of occult ... | 11/08/2011 |
| 8048641 | Micropatterning of biological molecules using laser ablation The present invention employs the natural hydrophilic properties of a macromolecular film such as a hydrogel and in combination with localized photo-ablation of monolayers created with the hydrogel using multi-photon laser excitation, provides a stampless, versatile... | 11/01/2011 |
| 8048640 | Methods for evaluating and implementing prostate disease treatments Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human pros... | 11/01/2011 |
| 8043824 | Methods for determining the redox status of proteins A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine group therein; b) contacting the sample with a reducing agent to reduce at... | 10/25/2011 |
| 8039222 | Treatment and prevention of tissue damage A method for the treatment or prevention of tissue damage in a subject having an inflammatory and/or tissue damaging condition, which comprises administering to the subject an effective amount of a compound capable of inhibiting the binding of C-reactive protein (CR... | 10/18/2011 |
| 8039223 | Method of selectively assaying adiponectin multimers Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot b... | 10/18/2011 |
| 8039225 | Method to identify patients at risk for lung transplant rejection Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one method pulmonary disease and disorders such as Idiopathic Pulmonary ... | 10/18/2011 |
| 8039224 | Gene specifically expressed in postmitotic dopaminergic neuron precursor cells A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in te... | 10/18/2011 |
| 8034576 | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt thereof;... | 10/11/2011 |
| 8030011 | Biomarkers and assays for myocardial infarction Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinica... | 10/04/2011 |
| 8030010 | Method for detecting a biomarker of oxidative stress in a biological sample A method for characterizing oxidative stress. The method includes dosing a ratio of HNE-to-DHN-protein in blood; comparing the ratio of HNE-to-DHN-protein in blood to a predetermined interval of ratio values associated with a predetermined level of oxidative stress;... | 10/04/2011 |
| 8026075 | Method for stabilizing coenzyme and composition thereof Disclosed is a sugar and/or a sugar alcohol as a substance for suppressing dephosphorylation reaction of a phosphorylated coenzyme. Also disclosed is a method for stabilizing a phosphorylated coenzyme which is characterized by having at least a substance for suppres... | 09/27/2011 |
| 8021853 | Inhibition of the β3 subunit of L-type Cachannels The present invention provides reagents and methods for identifying inhibitors of the L-type Ca2+ channel β3 protein, which has been demonstrated to be involved in calcium signaling, insulin secretion, and glucose homeostasis. The invention al... | 09/20/2011 |
