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| Number | Title | Issue Date |
| 8187821 | Compositions and methods for the modulation of PGRMC1 The present invention provides for novel assays and the use of such assays for screening compounds that affect PGRMC1's and related homologue's ability to catalyze the incorporation of cholesterol into membranes. The present invention also provides for methods and c... | 05/29/2012 |
| 8187822 | Methods to identify modulators Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided. ... | 05/29/2012 |
| 8178058 | High throughput cell-based assays, methods of use and kits In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform th... | 05/15/2012 |
| 8178308 | Use of IL-27 agonists to increase interferon-gamma production Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders. ... | 05/15/2012 |
| 8173378 | Methods of using an alpha-1-adrenergic receptor having altered ligand affinity A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPC... | 05/08/2012 |
| 8168401 | Methods of detecting T1R2- and T1R3-expressing cells potentially sensitive to sweet tastants The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including mo... | 05/01/2012 |
| 8168392 | Tetrahydrofolate synthetase gene By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is provided, and a judging method, a preventing method and a treating method ... | 05/01/2012 |
| 8163505 | Methods using PBK1 for identifying agents that treat metabolic disorders The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a recombinant nucleic acid encoding a PBK1 protein; a method of identifying a ... | 04/24/2012 |
| 8153385 | Target protein and target gene in drug designing and screening method The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods f... | 04/10/2012 |
| 8133689 | Members of the capsaicin/vanilloid receptor family of proteins and uses thereof The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expre... | 03/13/2012 |
| 8129130 | High affinity antibodies against HMGB1 and methods of use thereof Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifical... | 03/06/2012 |
| 8124355 | Detection and identification of groups of bacteria The present invention concerns a method for the simultaneous detection of different bacteria, comprising the following steps: coupling one or more species of bacteriophage tail proteins onto a support, incubating the support coupled with the bacteriophage tail prote... | 02/28/2012 |
| 8124356 | Methods of purifying zsig33 The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and ... | 02/28/2012 |
| 8105793 | Process for in vivo treatment of specific biological targets in bodily fluids A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly,... | 01/31/2012 |
| 8105792 | Method of modulating human ENaC sodium channel In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human ta... | 01/31/2012 |
| 8084221 | Method of screening for a drug candidate that increases ATP release from RBCs stimulated via the Gs or Gi pathway The invention is based upon the discovery that red blood cells contain phosphodiesterase 3B (PDE3B), and that inhibition of that phosphodiesterase allows for an enhanced accumulation of cAMP and subsequent release of ATP. It was further discovered that RBCs treated ... | 12/27/2011 |
| 8071318 | High throughput method and system for screening candidate compounds for activity against target ion channels Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields ... | 12/06/2011 |
| 8071319 | Rapid microbial detection and antimicrobial susceptibiility testing A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the prese... | 12/06/2011 |
| 8067339 | Surface display of whole antibodies in eukaryotes Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukary... | 11/29/2011 |
| 8058019 | Method for assaying antibodies in body fluids by immune reaction with glycoprotein 2 (GP2) from zymogenic granules of the pancreas for the differential diagnosis of inflammatory intestinal diseases and chronic pancreatitis The invention relates to a method for the detection of antibodies from body fluids via immune reaction with GP2 from pancreatic zymogenic granules, immunoreactive sequences or analogs thereof, excluding tissue sections. ... | 11/15/2011 |
| 8043823 | Methods of identifying agonists and antagonists of hTASR bitter taste receptors The present invention relates to agonists of the human bitter-taste receptors hTAS2R46, hTAS2R47 and hTAS2R50 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R... | 10/25/2011 |
| 8034574 | Screening method for prokinetic agent The present invention provides a screening tool and screening method for obtaining a substance useful as a prophylactic and/or therapeutic drug for diseases associated with 5-HT production/secretion abnormalities, including digestive organ diseases, and a prophylact... | 10/11/2011 |
| 8034575 | Screening systems utilizing RTP801 RTP801 represents a unique gene target for hypoxia-inducible factor-1 (HIF-1). Down-regulation of the mTOR pathway activity by hypoxia requires de novo mRNA synthesis and correlates with increased expression of RTP801. The present invention relates to screeni... | 10/11/2011 |
| 8030008 | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use of these receptors in assays for identifying ligands that modulate th... | 10/04/2011 |
| 8030009 | Human T2R67 taste receptor and related assays for identifying human bitter taste modulators The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R67 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligand... | 10/04/2011 |
| 8026074 | Methods of using GPR119 to identify compounds useful for increasing bone mass in an individual The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone ma... | 09/27/2011 |
| 8026073 | Screening G protein-coupled receptor antagonists for methods of treating Alzheimer's disease A method for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology includes the steps of: (a) activating a receptor and determining a first extent of endocytosis of the receptor, wherein the receptor is a G-protein coup... | 09/27/2011 |
| 8012702 | H-gated ion channel The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated o... | 09/06/2011 |
| 8012701 | Agonists of bitter taste receptors and uses thereof The present invention relates to agonists of the human bitter-taste receptor hTAS2R3 and its role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R3 bitter taste transduction or bi... | 09/06/2011 |
| 8008028 | Panel cell used for granulocyte antibody detection A panel cell for detecting anti-HNA antibody is disclosed. The panel cell is obtained by introducing a DNA coding for an HNA antigen corresponding to the anti-HNA antibody into a cell so as to enable the expression of the DNA under the condition for use in the detec... | 08/30/2011 |
| 7998692 | Agonists of bitter taste receptors and uses thereof The present invention relates to agonists of the human bitter-taste receptor hTAS2R7 and its role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R7 bitter taste transduction or bi... | 08/16/2011 |
| 7993853 | Methods of nucleic acid target capture Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a ... | 08/09/2011 |
| 7977279 | Differential phage capture proteomics Disclosed herein are methods for identifying, isolating and comparing proteins and other biomolecules differing between two complex biological samples using affinity chromatography and phage display techniques. ... | 07/12/2011 |
| 7968305 | Biochips including ion transport detecting structures and methods of use The present invention recognizes that the determination of ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, s... | 06/28/2011 |
| 7964365 | Methods for diagnosing and monitoring the progression of cancer Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided. ... | 06/21/2011 |
| 7964364 | Cell isolation method The present invention relates to a method of isolating cells from a sample which method comprises binding said cells to a solid support by means of a non-specific ligand immobilised on said solid support, particularly to a method of isolating microorganisms from a s... | 06/21/2011 |
| 7960129 | Assays and methods for determining STIM2 activity The present invention provides assays and methods for determining levels of STIM2 activity, thus providing tools for the characterization and study of the regulation of intracellular calcium levels. ... | 06/14/2011 |
| 7960128 | TRP8, a transient receptor potential channel expressed in taste receptor cells The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The in... | 06/14/2011 |
| 7960127 | TRP8, a transient receptor potential channel expressed in taste receptor cells The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The in... | 06/14/2011 |
| 7947462 | Methods for identifying Kremen polypeptide binding partners The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g. tumors or diseases of the kidneys, bones and eyes, lipid and glucose m... | 05/24/2011 |
