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| Number | Title | Issue Date |
| 8187817 | Diagnosis, treatment, and prevention of vascular disorders using IL-1 autoantibodies Methods of detecting individuals at risk for atherosclerosis and related vascular diseases involving the detection of IL-1α autoantibodies, as well as therapeutic methods to prevent or treat atherosclerosis and related vascular disease by administering a pharmaceut... | 05/29/2012 |
| 8187819 | Methods of identifying compounds that bind TANGO240 The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode se... | 05/29/2012 |
| 8187804 | Specific marker Lmx1a on dopaminergic neurons The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be u... | 05/29/2012 |
| 8187818 | Use of sPLAactivity for the diagnosis of a cardiovascular event A method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, includes:—determining the sPLA2 activity of the patient as a first risk marker—determining at least the value of a second risk marker chosen among CRP lev... | 05/29/2012 |
| 8187820 | Detection method using nanoaggregate-embedded beads and system thereof The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which ... | 05/29/2012 |
| 8182998 | Blood biomarkers for bone fracture and cartilage injury Blood biomarkers are described for use in methods and compositions to determine whether an individual has sustained a bone fracture or a cartilage injury. ... | 05/22/2012 |
| 8183000 | Diagnosis of liver pathology through assesment of protein glycosylation Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting lectin binding on proteins in biological fluids, and comparing the detected lectin binding with reference values ... | 05/22/2012 |
| 8182999 | Compositions and methods for early pregnancy diagnosis Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta.... | 05/22/2012 |
| 8182997 | Prostate cancer related gene STYK1 The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the STYK1 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention ... | 05/22/2012 |
| 8178306 | Systems and methods of removing and managing heavy metals Systems and methods remove and manage heavy metals. In one implementation, an exemplary method can be applied to food processing and food consumption to remove heavy metals such as mercury, lead, uranium and cadmium before absorption by a living organism. The exempl... | 05/15/2012 |
| 8178307 | Methods and compositions for detection of lethal cell and uses thereof The present invention relates to methods and compositions for identifying and detecting lethal cell useful for monitoring disease status and therapy response in various types of cancer patients regardless of the etiological origin of the cancer and uses thereof.... | 05/15/2012 |
| 8178305 | Method of analyzing biochemical A method of highly sensitive and quantitative luminescent analysis with the use of a detection device using a micro-channel and carrying a molecule which is capable of capturing a substance to be detected and bonded to a solid phase. A biochemical to be detected is ... | 05/15/2012 |
| 8178302 | Mouse models for studying and treating hepatocellular and gastrointestinal tumors A mouse model is provided which is directed to mice bred to have a disruption in the TGF-β signaling pathways which causes tumorigenesis in the liver and gut of the developing mice. The mice models of the invention include those mice whose genome include at least o... | 05/15/2012 |
| 8178303 | Increasing the speed of cryoglobulin precipitation The present invention provides a method for the precipitation of cryoglobulins. In general, the method comprises the steps of: (a) providing a cryoglobulin sample; (b) providing a reagent such as a buffer reagent for decreasing the ionic strength of the sample; (c) ... | 05/15/2012 |
| 8178304 | Diagnostic methods relating to Graves' disease and other autoimmune disorders The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+ IGF-R+... | 05/15/2012 |
| 8173369 | Peripheral gene expression biomarkers for autism The disclosed invention comprises methods and materials for screening cells for genetic profiles associated with autism spectrum disorders. The methods typically involve isolating a cell from an individual and then observing the expression profile of one or more gen... | 05/08/2012 |
| 8173372 | Methods of donor specific crossmatching The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating Tie-2+ and CD34− precursor endothelial cells for use in donor-specific crossmatching. | 05/08/2012 |
| 8173377 | Methods and compositions for determining the purity of chemically synthesized nucleic acids This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic pro... | 05/08/2012 |
| 8173374 | Human embryonic stem cell methods and PODXL expression A method of identifying an undifferentiated human embryonic stem cell in a sample which may contain such cells, the method comprising identifying the cell or cells within the sample that express podocalyxin-like protein (PODXL) on their surface. A method of isolatin... | 05/08/2012 |
| 8173375 | Rabbit monoclonal antibodies to hepatitis B surface antigens and methods of using the same Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a”... | 05/08/2012 |
| 8173373 | Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling Methods for screening compounds that modulate umami taste signaling in taste cells are provided. These methods comprise contacting a compound with hetero-oligomeric taste transduction G-protein coupled receptors that respond to umami taste stimuli, and determining w... | 05/08/2012 |
| 8173376 | Method for identifying compounds for treatment of pain Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the act... | 05/08/2012 |
| 8168400 | Methods and kits for detection of thromboxane A2 metabolites Methods, compositions and kits are provided for measuring aspirin's anti-thrombotic effectiveness on a subject. Included are a novel assay for quickly and specifically measuring TxA2 metabolite levels in urine and correlating the levels with aspirin dose in a subjec... | 05/01/2012 |
| 8168397 | Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins a... | 05/01/2012 |
| 8168398 | Asbestos exposure, pleural mesothelioma, and osteopontin levels The present invention provides diagnostic methods based on levels of osteopontin. ... | 05/01/2012 |
| 8168399 | Supports for assaying analytes and methods of making and using thereof Described herein are supports for assaying an analyte and methods of making and using thereof. ... | 05/01/2012 |
| 8168396 | Methods for detecting pre-diabetes and diabetes using differential protein glycosylation Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed ... | 05/01/2012 |
| 8168395 | Taste receptors of the T1R family from domestic dog The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the ... | 05/01/2012 |
| 8168394 | Method for simultaneously detecting an antigen of, and an antibody against, an infectious microorganism The invention relates to a method for detecting, in vitro, an infection with a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneously detecting an antigen of this microorganism and the antibodies against this same antigen, and also t... | 05/01/2012 |
| 8168391 | Method for modulating insulin production The present invention provides screening methods for the detection of agents that affect various aspects of β-cell biology, particularly insulin gene expression. Screening methods are also provided for detection of agents that affect β-cell differentiation from pr... | 05/01/2012 |
| 8168393 | Compositions and methods for diagnosing tumors using LEDGF/p75 The invention provides methods for diagnosing tumors in mammals using a reagent that bind to LEDGF/p75 or to a nucleic acid encoding LEDGF/p75. For example, the tumor may be located in the CNS, the prostate, the skin, the bone marrow, or the gut of the mammal. Also ... | 05/01/2012 |
| 8163500 | Polypeptides and methods for the specific detection of antibodies in patients with a infection The present disclosure relates to proteins derived from OspC from bacteria of the genus Borrelia, in particular a protein which comprises a first OspC polypeptide, wherein the first OspC polypeptide is linked to a second OspC polypeptide via a disulphide brid... | 04/24/2012 |
| 8163501 | Methods of assessing Crohn's disease patient phenotype by I2 serologic response The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA ant... | 04/24/2012 |
| 8163504 | Combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event A method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, includes: measuring, in a sample obtained from the subject, at least two cardiovascular risk factor... | 04/24/2012 |
| 8163503 | Methods of identifying compounds that bind TANGO509 The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid... | 04/24/2012 |
| 8163498 | Method for determination of molecular weight of hyaluronic acid A method of measuring a molecular weight of hyaluronic acid, comprising at least reacting hyaluronic acid in a sample containing the hyaluronic acid with a hyaluronic acid-binding protein to measure an amount of the hyaluronic acid-binding protein that is bound to t... | 04/24/2012 |
| 8163502 | Method for predicting the risk of disease based on lectin binding Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of the saliva... | 04/24/2012 |
| 8163495 | Method for isolating and/or identifying mesenchymal stem cells (MSC) The present invention concerns antibodies produced from hybridoma cell lines chosen from the group comprising W8B2, W1C3, W7C6, W5C4, 24D2, 28D4, HEK-3D6, W4A5, W3D5, W5C5, 9A3G9, 58B1, F9-3C2F1, 39D5, for isolating and/or identifying homogenous mesenchymal stem cel... | 04/24/2012 |
| 8163499 | Drug selection for breast cancer therapy using antibody-based arrays The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the inven... | 04/24/2012 |
| 8163496 | Methods and kits for measuring von Willebrand factor Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having at least two of a G233V, D235Y and M239V mutations and an agent to d... | 04/24/2012 |
