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| Number | Title | Issue Date |
| 8163522 | Human TNF receptor The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD ... | 04/24/2012 |
| 8137932 | Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2 scFv fragment The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment. ... | 03/20/2012 |
| 7811792 | Protocol and apparatus for determining heparin-induced thrombocytopenia A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 10/12/2010 |
| 7422856 | Methods for modulating transcriptional activation using mint proteins The present invention is directed to isolated nucleic acids encoding Mint protein variants having enhanced abilities to modulate the transcriptional activation mediated by the cytoplasmic tail of the amyloid precursor protein (APP) relative to wild-type Mint protein... | 09/09/2008 |
| 7413876 | Expression of G protein coupled receptors in yeast Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protein-coupled receptor and a second heterologous DNA sequence which codes for a mammalian G protein α subunit (mammalian Gα). The first an... | 08/19/2008 |
| 7351549 | Method for the manufacture of recombinant trypsin The present invention relates to a method for the manufacture and purification of recombinant trypsinogen and trypsin in E. coli and yeast, using high yield expression vectors with and without secretion leader sequences. The invention further relates to an im... | 04/01/2008 |
| 7279309 | Process for manufacture of Nematode-extracted Anticoagulant Protein (NAP) The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug substance that can be formulated as a NAP drug product. The present invent... | 10/09/2007 |
| 7270979 | DNA for expression of alpha 1-antitrypsin in methylotropic yeast Alpha 1-antitrypsin is prepared by growing in a fermentor methylotropic yeast transformants containing in their genome at least one copy of DNA encoding alpha 1-antitrypsin, in operational linkage with DNA encoding a signal sequence, which is effective for directing... | 09/18/2007 |
| 7262287 | yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encoding H. polymorpha yapsin1, a polypeptide encoded by the nucleic acid molecule, a H. polymorpha mutant strain having reduced yapsin activity by mutation of the HpYP... | 08/28/2007 |
| 7238356 | Core-glycosylated HCV envelope proteins The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in that on average up to 80% of their N-glycosylation sites are core-glyco... | 07/03/2007 |
| 7202356 | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast The regulatory sequences (i.e., promoter regions, introns and enhancers) associated with the Yarrowia lipolytica gene encoding fructose bis-phospate aldolase (FBA1) have been found to be particularly effective for the expression of heterologus genes in oleagi... | 04/10/2007 |
| 7198919 | Use of alpha factor sequences in yeast expression systems The isolation of the yeast α-factor genes is described. The promoter and signal peptide portions are isolated and joined to DNA coding for proteins heterologous to yeast in a plasmid which is used to transform yeast cells. The yeast expresses the heterologous DNA a... | 04/03/2007 |
| 7060461 | Methods and compositions for protein expression and purification Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed. ... | 06/13/2006 |
| 7026150 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 04/11/2006 |
| 6962796 | Production of human parathyroid hormone from microorganisms The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli, transformed by these plasmids. The invention also provides a plasmid for in... | 11/08/2005 |
| 6951734 | Methods for producing proteins by using cell-free protein synthesis systems A method for producing a protein suitable for X-ray crystallographic analysis, in a cell-free protein synthesis system comprising a cell-free extract, a nucleic acid coding for said protein, and amino acids for the substrate of said protein, wherein said amino acids... | 10/04/2005 |
| 6924125 | Expression of heterologous multi-domain proteins in yeast This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the inclusion of a plurality of (up to three) modular expression cassettes which... | 08/02/2005 |
| 6858384 | Phage antibodies Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antib... | 02/22/2005 |
| 6858409 | Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors Compounds are disclosed having the general formula R1—X—R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2 ... | 02/22/2005 |
| 6855550 | Expression of G protein coupled receptors in yeast Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protean coupled receptor and a second heterologous DNA sequence which codes for a mammalian G protein α subunit (mammalian Gα). The first an... | 02/15/2005 |
| 6828132 | Biological fertilizer compositions comprising garbage The present invention provides biological fertilizer compositions that comprise yeast cells and garbage. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals ... | 12/07/2004 |
| 6828131 | Biological fertilizer based on yeasts The present invention provides biological fertilizer compositions that comprise yeast cells that have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon c... | 12/07/2004 |
| 6824997 | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is conjugated to a spacer molecule, and the free end of the latter is then c... | 11/30/2004 |
| 6800466 | Biological fertilizer compositions comprising sludge The present invention provides biological fertilizer compositions that comprise yeast cells and sludge. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals a... | 10/05/2004 |
| 6733997 | Isolated nucleic acids encoding a secretory signal for expression and secretion of heterologous recombinant proteins A universal secretory signal originally derived from a piscine vitellogenin (Vtg) gene is inserted into various expression vectors for driving the secretion of the recombinant protein into the culture medium. This enhances the detection, quantification and downstrea... | 05/11/2004 |
| 6730303 | Fused G-CSF and IL-3 proteins and uses thereof Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the mu... | 05/04/2004 |
| 6645739 | Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same The present invention provides novel expression systems for producing desired polypeptides in certain strains of yeast. The present invention further provides methods for producing polypeptide products using such expression systems. The present invention ... | 11/11/2003 |
| 6642029 | Hybrid DNA synthesis of mature insulin-like growth factors Methods and compositions are provided for efficient production of human insulin-like growth factor. Synthetic IGF I and IGF II genes are joined to leader and processing signals which provide for expression and secretion of the gene product in yeast. Enhan... | 11/04/2003 |
| 6596272 | Biological fertilizer compositions comprising poultry manure The present invention provides biological fertilizer compositions that comprise yeast cells and poultry manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose p... | 07/22/2003 |
| 6562576 | Yeast two-hybrid system and use thereof A method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in yeast cells. The interaction between the two fusion proteins leads to protein trans-splicing, generating ... | 05/13/2003 |
| 6551786 | Screen assay for selecting protein-protein interaction modulators A method for selecting compounds capable of modulating protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in the presence of test compounds. The interaction between the two fusion pr... | 04/22/2003 |
| 6545140 | DNA encoding an avian beta-defensin and uses thereof An isolated nucleic acid molecule encoding avian beta-defensin is provided. Further provided are compositions comprising an avian beta-defensin, or portions thereof.... | 04/08/2003 |
| 6534286 | Protein production in Aureobasidium pullulans The present disclosure provides methods and DNA molecules for the synthesis of heterologous proteins in the fungus Aureobasidium pullulans either intracellularly or with secretion out of the cells using a regulated xylanase promoter and for secreted prote... | 03/18/2003 |
| 6509447 | G protein chimeras and methods of screening compounds A chimeric G protein having yeast G (Gpa1p) amino acid sequences modified by a minimum of 3 amino acids positions within the C-terminal 10 amino acids by substitution by alternative amino acids, a transformed yeast cell... | 01/21/2003 |
| 6503749 | Yeast strains possessing the interrupted ATF2 gene and their applications A subject of the invention is a modified yeast strain in which the acetyl-CoA pregnenolone acetyltransferase (APAT) activity is eliminated by altering the gene coding for this activity with resultant stabilization of 3ଲ-hydroxysteroids.... | 01/07/2003 |
| 6479735 | Transgenic plants including a transgene consisting of a hybrid nucleic acid sequence, comprising at least one unedited mitochondrial gene fragment from higher plants and process for producing them Hybrid nucleic acid sequences including at least the coding region of an unedited mitochondrial gene of superior plants and controlling the male fertility of plants containing said sequences, transgenic plants having such sequences and methods of producti... | 11/12/2002 |
| 6458527 | HIV immunoassays using gag polypeptides Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides... | 10/01/2002 |
| 6416983 | Biological fertilizer compositions comprising garbage The present invention provides biological fertilizer compositions that comprise yeast cells and garbage. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassiu... | 07/09/2002 |
| 6306625 | Method for obtaining expression of mixed polypeptide particles in yeast The present invention provides a method for obtaining expression of a mixed hepatitis B surface antigen particle, e.g., a particle of mixed polypeptide composition, in yeast. Also disclosed is a method for obtaining multimeric structures presenting two or... | 10/23/2001 |
| 6303319 | Cell based assay for identifying sh2-domain-specific signal transducer antagonist The present invention provides methods and compositions for identifying inhibitors of the interaction between phosphopeptide binding pairs, i.e., a protein domain having at least one phosphopeptide binding domain and the phosphorylated ligands that bind t... | 10/16/2001 |
