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| Number | Title | Issue Date |
| 8183014 | High affinity antibodies to human IL-6 receptor A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody... | 05/22/2012 |
| 8178320 | Artificial antibody library with super-repertory An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing... | 05/15/2012 |
| 8158385 | Cell death-inducing agent To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing acti... | 04/17/2012 |
| 8093017 | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders. ... | 01/10/2012 |
| 8084233 | Nucleic acids encoding anti-IL-12 antibody Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.... | 12/27/2011 |
| 8062865 | Expression control using antibody expression optimisation sequences The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, character... | 11/22/2011 |
| 8043832 | Method for determination of inflammatory bowel disease The instant invention provides a method for the differential diagnosis of inflammatory bowel disease which comprises, determining the relative ratio of G0 oligosaccharide represented by formula (I): to G2 oligosaccha... | 10/25/2011 |
| 8034585 | Superagonistic anti-CD28 antibodies The present invention relates to one or more nucleic acid(s) encoding a binding molecule specifically binding to a human CD28 molecule, comprising (a) a nucleic acid sequence encoding a VH region and a nucleic acid sequence encodin... | 10/11/2011 |
| 8021858 | Method for making polyalkylene oxide modified hemoglobin The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product... | 09/20/2011 |
| 8012714 | Sequence diversity generation in immunoglobulins Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does ... | 09/06/2011 |
| 7993878 | Antibodies to human IL-1β An IL-1β binding molecule, in particular an antibody to human IL-1β, especially a human antibody to human IL-1β is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease ... | 08/09/2011 |
| 7993877 | Process for the purification of recombinant albumin A process is provided for the preparation of a highly pure recombinant albumin solution having a nickel ion content of less than 100 ng per gram of albumin. The process comprises subjecting a recombinant albumin to a series of chromatography, concentration, and diaf... | 08/09/2011 |
| 7977071 | Binding moieties based on shark ignar domains The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been mo... | 07/12/2011 |
| 7968316 | Method for the mass production of immunoglobulin Fc region deleted initial methionine residues Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising... | 06/28/2011 |
| 7943343 | Production and use of novel peptide-based agents for use with bi-specific antibodies The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten ... | 05/17/2011 |
| 7943344 | Hepatocyte growth factor (HGF) binding proteins The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic a... | 05/17/2011 |
| 7943342 | Nucleic acids encoding IL-13 binding agents Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed. ... | 05/17/2011 |
| 7935502 | Hepatocyte growth factor (HGF) binding proteins The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic a... | 05/03/2011 |
| 7927834 | Recombinant production of mixtures of antibodies The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recomb... | 04/19/2011 |
| 7923221 | Methods of making antibody heavy and light chains having specificity for a desired antigen The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce... | 04/12/2011 |
| 7919273 | Structural variants of antibodies for improved therapeutic characteristics The present invention provides substituted humanized, chimeric or human anti-CD20 antibodies or antigen binding fragments thereof and bispecific antibodies or fusion proteins comprising the substituted antibodies or antigen binding fragments thereof. The antibodies,... | 04/05/2011 |
| 7910332 | Method for manufacturing a recombinant polyclonal protein The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid ... | 03/22/2011 |
| 7867734 | Anti-glypican 3 antibody having modified sugar chain An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a ... | 01/11/2011 |
| 7846691 | Polynucleotide encoding an anti-FGF19 antibody The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4. ... | 12/07/2010 |
| 7833755 | Anti-IL-6 antibody nucleic acid molecules and methods Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. ... | 11/16/2010 |
| 7807414 | Anti-IL-23 antibodies, compositions, methods and uses An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, m... | 10/05/2010 |
| 7790414 | Methods for producing antibodies The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurali... | 09/07/2010 |
| 7771969 | Methods for obtaining antibodies The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recog... | 08/10/2010 |
| 7754450 | Methods of generating high-production of antibodies from hybridomas created by in vitro immunization The invention provides methods for generating high titers of high-affinity antibodies from hybridoma cells produced by fusing myeloma cells with in vitro immunized donor cells. The hybridoma cells or mammalian expression cells with cloned antibody genes from the hyb... | 07/13/2010 |
| 7741077 | Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymph... | 06/22/2010 |
| 7727743 | Method for stabilizing a cryoprecipitate of plasmatic proteins for being subjected to a viral inactivation thermal treatment The invention relates to a method for obtaining cryoprecipitatable proteins, comprising a viral inactivation step by thermally treating a lyophilisate of these proteins, comprising, before rendering the proteins in the form of a lyophilisate, an initial addition ste... | 06/01/2010 |
| 7709226 | Method of humanizing antibodies by matching canonical structure types CDRs Disclosed herein are methods for humanizing antibodies based on selecting variable region framework sequences from human antibody genes by comparing canonical CDR structure types for CDR sequences of the variable region of a non-human antibody to canonical CDR struc... | 05/04/2010 |
| 7670804 | Chimeric, human and humanized anti-CSAP monoclonal antibodies The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers, including colon cancer. ... | 03/02/2010 |
| 7635577 | Process for producing human thrombin by gene modification technique A genetic recombinant human thrombin is provided. Human thrombin is efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transfectant animal cell transfected with an expression vector in which a gene encoding human prethrom... | 12/22/2009 |
| 7625721 | Non-precipitating bodily fluid analysis system A bodily fluid analyzer including a dry test strip impregnated with a reagent providing a non-precipitating reaction to exclude non-desired analytes. The reagent complexes the non-desired analytes so they remain in solution but cannot participate in the test reactio... | 12/01/2009 |
| 7608429 | Methods and compositions for increasing antibody production The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. T... | 10/27/2009 |
| 7601515 | Process of high purity albumin production A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, an... | 10/13/2009 |
| 7563599 | Reshaped human antibody to human medulloblastoma cells The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L ch... | 07/21/2009 |
| 7537916 | Efficient production of F(ab')fragments in mammalian cells The present invention provides immortalized eukaryotic cells and methods useful for the production of immunologically active bivalent antibody fragments, such as F(ab′)2 fragments. The methods and cells of the invention result in a desirable ratio of bi... | 05/26/2009 |
| 7521210 | Method for large-scale production of polypeptide in eukaryote cells and a culture vessel suitable therefor The invention provides a method for large-scale production of a polypeptide, such as a Factor VII or Factor VIIa polypeptide, in eukaryote cells, such as mammalian cells, contained in a culture liquid, said method comprising: monitoring the concentration of dissolve... | 04/21/2009 |
