Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 7923220 | Process for preparing high levels of interferon beta The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation. ... | 04/12/2011 |
| 7811791 | Interferon-like molecules and uses thereof The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides ... | 10/12/2010 |
| 7807413 | GAG binding protein A method is provided for introducing a GAG binding site into a protein comprising the steps: identifying a region in a protein which is not essential for structure maintenance introducing at least one basic amino a... | 10/05/2010 |
| 7749735 | IFNAR2 mutants, their production and use The present invention relates to mutant polypeptides of the beta chain of the type I IFN receptor (IFNAR2 mutant) with enhanced affinity for IFNβ as compared to the wild type protein for prolonging the effect of IFNβ in vivo. ... | 07/06/2010 |
| 7585647 | Nucleic acid encoding recombinant interferon This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and, therefore, is useful in preventing and treating viral diseases... | 09/08/2009 |
| 7527946 | Interferon-beta-1a-immunoglobulin fusion proteins and uses A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptid... | 05/05/2009 |
| 7419805 | Polynucleotides encoding S99T interferon gamma polypeptide variants and means of expression The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the polypeptide variants and their use in the treatment of diseases, in partic... | 09/02/2008 |
| 7390637 | Keratinocyte derived interferon The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors,... | 06/24/2008 |
| 7390638 | S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this constitutes a severe problem in that valuable polypeptide material is lost... | 06/24/2008 |
| 7381795 | Modified interferon beta with reduced immunogenicity A modified interferon beta (INFβ) is provided, which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered to a human in vivo. The modified INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by a substitution at one or mor... | 06/03/2008 |
| 7364724 | Recombinant super-compound interferon This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and therefore is useful to prevent and treat viral diseases and can... | 04/29/2008 |
| 7345149 | Cysteine substitution variants of beta interferon The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 03/18/2008 |
| 7338788 | Interferon-β variants and conjugates The present invention provides new interferon β conjugates, methods of preparing such conjugates and the use of such conjugates in therapy, in particular for the treatment of multiple sclerosis. ... | 03/04/2008 |
| 7335761 | Avian gene expression controlling regions The present invention includes avian ovomucoid gene expression controlling regions which may be operably linked to one or more useful amino acid coding sequences. ... | 02/26/2008 |
| 7332649 | Changing the fine chemical content in organisms by genetically modifying the shikimate pathway The present invention relates to a process for the production of fine chemicals, in particular vitamin E, vitamin K and/or ubiquinone by culturing organisms, in particular plants, whose shikimate pathway is genetically modified over that of the wild type, and to the... | 02/19/2008 |
| 7317142 | Immunization of fish with plant-expressed recombinant proteins Plants are produced that express an amino acid sequence that, when administered to a fish, produce an antigenic or immune response in the fish. The amino acid sequence in one embodiment is an antigen from an organism that causes pathology in fish. The plant tissue m... | 01/08/2008 |
| 7314719 | Method for increasing productivity of secondary metabolite by conferring drug-resistant mutations This invention relates to a method for increasing the productivity of the secondary metabolite in a micro-organism, for example, the improvement of antibiotic producers by conferring drug-resistant mutations to micro-organisms. ... | 01/01/2008 |
| 7311902 | Conjugates comprising human IL-18 and substitution mutants thereof Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjuga... | 12/25/2007 |
| 7311903 | Glycosylated human interferon alpha isoform The present invention relates to an amino acid-modified human interferon alpha isoform having at least one of the Asn-Xaa-Ser/Thr (N-X-S/T) sequence formed at a specific site so that glycosylation takes place at this site and a gene encoding the same, an expression ... | 12/25/2007 |
| 7294507 | Ovomucoid promoters and methods of use The present invention includes nucleic acid molecules comprising an artificial chromosome and an avian ovomucoid gene expression controlling region operably linked to the coding sequence of a useful polypeptide. ... | 11/13/2007 |
| 7270809 | Cysteine variants of alpha interferon-2 The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 09/18/2007 |
| 7268120 | Methods for treating cancer using cytokine-expressing polynucleotides The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or more cationic compounds. The present invention also provides methods o... | 09/11/2007 |
| RE39821 | Manufacture and expression of large structural genes Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products, which products differ from naturally-occurring forms in terms of the... | 09/04/2007 |
| RE39788 | Gene therapy Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy. ... | 08/21/2007 |
| 7252969 | Interferon-like protein Zcyto21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypept... | 08/07/2007 |
| 7253261 | Interferon-like protein Zcyto21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypept... | 08/07/2007 |
| 7241870 | Interferon-like protein Zcyto21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypept... | 07/10/2007 |
| 7235232 | Interferon alpha hybrids Hybrid human interferon-α polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these peptides, and the use of these polypeptides to treat viral disease and regulate cell growth are also provided. ... | 06/26/2007 |
| 7232562 | E38N interferon gamma polypeptide variants A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one i... | 06/19/2007 |
| 7230081 | Interferon gamma conjugates A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one i... | 06/12/2007 |
| 7217689 | Glycosylation analogs of erythropoietin Erythropoietin analogs having at least one additional site for glycosylation, or a rearrangement of at least one site for glycosylation are disclosed. The invention also relates to DNA sequences encoding said erythropoietin analogs, and recombinant plasmids and host... | 05/15/2007 |
| 7198919 | Use of alpha factor sequences in yeast expression systems The isolation of the yeast α-factor genes is described. The promoter and signal peptide portions are isolated and joined to DNA coding for proteins heterologous to yeast in a plasmid which is used to transform yeast cells. The yeast expresses the heterologous DNA a... | 04/03/2007 |
| 7183108 | Selection and uses of lactic acid bacteria strains modulating non-specific immunity The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said enterocytes. The strains can also be incorporated in food supplements such as fe... | 02/27/2007 |
| 7176002 | Universal-tagged oligonucleotide primers and methods of use The present invention relates to universal-tagged oligonucleotide primers, and to methods of using the primers for amplifying the genome. ... | 02/13/2007 |
| 7161064 | Method for producing stably transformed duckweed using microprojectile bombardment Methods and compositions for the efficient transformation of duckweed are provided. The methods involve transformation by ballistic bombardment. In this manner, any gene or nucleic acid of interest can be introduced and expressed in duckweed plants. Transformed duck... | 01/09/2007 |
| 7148333 | Cysteine variants of granulocyte-macrophage colony-stimulating factor The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 12/12/2006 |
| 7141392 | Latent fusion protein The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comp... | 11/28/2006 |
| 7135458 | Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel IFN-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised ag... | 11/14/2006 |
| 7129390 | Poultry Derived Glycosylated Interferon Alpha 2b This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, tran... | 10/31/2006 |
| 7122185 | Anti-CCR5 antibody The invention is directed an anti-CCR5 antibody which comprises (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO140-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprisi... | 10/17/2006 |
