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| Number | Title | Issue Date |
| 8129146 | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin ana... | 03/06/2012 |
| 8114632 | Method of producing biologically active polypeptide having insulinotropic activity The present invention relates to a method of producing a biologically active polypeptide having insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified host cell that has protease gene knockout, with a polynucleotide vector e... | 02/14/2012 |
| 8080391 | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or... | 12/20/2011 |
| 7947473 | Methods for expression and purification of pegylated recombinant human growth hormone containing a non-naturally encoded keto amino acid The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encod... | 05/24/2011 |
| 7947472 | Expression vectors and cell lines expressing vascular endothelial growth factor D This invention relates to expression vectors comprising VEGF-D and its biologically active derivatives, cell lines stably expressing VEGF-D and its biologically active derivatives, and to a method of making a polypeptide using these expression vectors and host cells... | 05/24/2011 |
| 7939296 | Method for production of recombinant human FSH Disclosed is a method for production of recombinant human FSH in high yield and a high purity. The method comprises the steps of: (a) culturing recombinant human FSH-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting... | 05/10/2011 |
| 7888070 | Nucleic acids encoding growth hormone with a modified RSP sorting signal The invention provides a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provi... | 02/15/2011 |
| 7883868 | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptide and heterodimer thereof Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, spec... | 02/08/2011 |
| 7871798 | Mammalian cells that express VEGF-D polypeptides Disclosed herein are mammalian cells transformed or transfected with a VEGF-D nucleic acid consisting of a nucleotide sequence encoding continuous portions of VEGF-D polypeptides. ... | 01/18/2011 |
| 7858344 | Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also... | 12/28/2010 |
| 7833753 | Methods of producing erythropoietin isoforms comprising Lewis-X structures and high sialic acid content and compositions of the same Disclosed are immortalized human embryonic retina cells, having a nucleic acid sequence encoding an adenoviral E1A protein integrated into the genome of the cells, and further comprising a nucleic acid sequence encoding an enzyme involved in post-translational modif... | 11/16/2010 |
| 7829310 | Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also... | 11/09/2010 |
| 7785838 | Variants of mammalian prolactin, prolactin receptor antagonists, and methods of use Mammalian prolactin (PRL) variants having a mutation or set of mutations within the 14 N-terminal amino acids that prevent the formation of a disulfide bridge between Cys4 and Cys11 and, a sterically hindering mutation or set of mutations withi... | 08/31/2010 |
| 7736872 | Compositions of aminoacyl-TRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also... | 06/15/2010 |
| 7727742 | Nucleic acid molecules encoding fibroblast growth factor-like polypeptides The present invention provides nucleic acid molecules encoding Fibroblast Growth Factor-like (FGF-like) polypeptides. The invention also provides vectors, host cells, and methods for producing FGF-like polypeptides. ... | 06/01/2010 |
| 7695938 | Vectors and recombinant host cells comprising nucleic acid molecules encoding Fibroblast Growth Factor-like polypeptides The present invention provides vectors and recombinant host cells comprising nucleic acid molecules encoding Fibroblast Growth Factor-like (FGF-like) polypeptides. The invention also provides methods for producing FGF-like polypeptides using such recombinant host ce... | 04/13/2010 |
| 7442376 | Glycoprotein hormone compositions containing two β subunits Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula β1-(linker1)m-α-(linker2)n-β2; (1) β1-(linker1 | 10/28/2008 |
| 7435553 | Isolating cells expressing secreted proteins A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic... | 10/14/2008 |
| 7411052 | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containi... | 08/12/2008 |
| 7396652 | Chemokine PANEC-2 polypeptides and compositions and methods related thereto The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which enco... | 07/08/2008 |
| 7393661 | Nucleic acids encoding OBG3 polypeptides The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. This application pertains to nucleic acids encoding a compound, globular OBG3 polypeptide fragments, vectors and transformed host cells... | 07/01/2008 |
| 7390654 | Avoidance of undesirable replication intermediates in plasmid propagation Disclosed herein are improved plasmid shuttle vectors, vaccines based on them, and methods related to their construction and use. Particular arrangements of functional elements of such plasmids, namely origins of replication and eukaryotic transcription/translation ... | 06/24/2008 |
| 7381804 | G-CSF analog compositions and methods The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions containing hybrid molecules. ... | 06/03/2008 |
| 7371813 | Method for use of IGF-binding protein for selective sensitization of target cells in vivo New methods for the treatment of human disease are provided. IGFBP-3 is administered together with a co-administered agent to subjects having disease, thereby alleviating the symptoms of the disease, under conditions where administration of IGFBP-3 alone at the maxi... | 05/13/2008 |
| 7368284 | Porcine CMP-N-Acetylneuraminic acid hydroxylase gene The present invention provides porcine CMP-N-Acetylneuraminic-Acid Hydroxylase (CMP-Neu5Ac hydroxylase) protein, cDNA, and genomic DNA regulatory sequences. Furthermore, the present invention includes porcine animals, tissues, and organs, as well as cells and cell l... | 05/06/2008 |
| 7365162 | Stabilized bioactive peptides and methods of identification, synthesis, and use An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus... | 04/29/2008 |
| 7361642 | Canine specific growth hormone releasing hormone A composition and a method of increasing growth hormone (“GH”) values in a canine or dog, and more specifically, a canine- or dog-specific growth hormone releasing hormone (“dGHRH”), or functional biological equivalent thereof. The dGHRH is an isolated compo... | 04/22/2008 |
| 7361486 | Polynucleotide, vector, host cell and method for producing human hepatoma-derived growth factor 5 polypeptide The invention provides a cDNA sequence of human hepatoma derived growth factor 5 (HDGF5). The present invention also relates to the polypeptides encoded by the nucleotide sequences, the uses of these polynucleotides and polypeptides, and the methods for producing HD... | 04/22/2008 |
| 7358341 | Beta-like glycoprotein hormone polypeptide and heterodimer Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, spec... | 04/15/2008 |
| 7355019 | Cysteine-containing peptide tag for site-specific conjugation of proteins The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; an... | 04/08/2008 |
| 7354739 | TML polynucleotides The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agon... | 04/08/2008 |
| 7351815 | Canine pre-proGHRH and mature GHRH genes The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-... | 04/01/2008 |
| 7345154 | Cysteine variants of erythropoietin The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 03/18/2008 |
| 7341999 | Povidone-containing carriers for polypeptide growth factors A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic tissues. The liquid medium comprises an aqueous solution of polyvinyl ... | 03/11/2008 |
| 7342099 | cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhi... | 03/11/2008 |
| 7338787 | Nucleic acids encoding OBG3 globular head and uses thereof The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body... | 03/04/2008 |
| 7326402 | Method of diagnosing, monitoring, staging, imaging and treating cancer The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer. ... | 02/05/2008 |
| 7323446 | Growth factor homolog ZVEGF4 Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residu... | 01/29/2008 |
| 7323550 | Anti-PRO4318 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 01/29/2008 |
| 7319144 | Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope f... | 01/15/2008 |
