Quotables
"The radio craze will die out in time."
Thomas Edison ; 1922
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8153400 | Nucleic acids encoding a domain-containing polypeptide The invention pertains to nucleic acids encoding a mutT domain-containing polypeptide, including fragments and biologically functional variants thereof. The invention also pertains to therapeutics and diagnostics involving the foregoing polypeptide and nucleic acids... | 04/10/2012 |
| 8148108 | Process for producing cellulase Various methods for the production of cellulase are disclosed. In one embodiment the method for producing cellulase includes contacting a culture comprising a sophorolipid producer and a cellulase producer with a substrate that is consumed by the sophorolipid produc... | 04/03/2012 |
| 8071551 | Methods and compositions for treating diabetes The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine protease inhibitor and thereafter monitoring a decrease in apoptosis. Th... | 12/06/2011 |
| 7994136 | Metalloproteinase inhibitor A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed. ... | 08/09/2011 |
| 7968314 | Methods employing a multi-time point IC50 assay for selecting time points for time dependent inhibition assays of a test compound The invention provides a method of evaluating metabolism-based drug interactions. The method involves selecting time points for the determination of the inactivation rate constant of a time-dependent enzyme inhibitor based on the results of a multi-time point IC50 t... | 06/28/2011 |
| 7915012 | Methods for screening for inhibitors of TRPV2 activation The present invention relates to a method for activation of TRPV2 (transient receptor potential vanilloid 2) using probenecid, more precisely a method for selecting a candidate for TRPV2 blocker using probenecid. Probenecid of the present invention works on TRPV2 sp... | 03/29/2011 |
| 7906302 | Methods of preventing or treating contact dermatitis This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermati... | 03/15/2011 |
| 7645595 | Method of production of artificial skin A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](... | 01/12/2010 |
| 7592157 | Expression in filamentous fungi of protease inhibitors and variants thereof Described herein are protease inhibitors, variants thereof and methods for their production. ... | 09/22/2009 |
| 7582448 | 84P2A9: a prostate and testis specific protein highly expressed in prostate cancer A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, b... | 09/01/2009 |
| 7560248 | Oxidation-resistant ribonuclease inhibitor Mutant forms of ribonuclease inhibitor are described which are rendered more resistant to oxidation while retaining affinity for both ribonuclease and angiogenin. The mutant forms have another amino acid, typically an alanine, substituted for one or more of the adja... | 07/14/2009 |
| 7449309 | Methods for desensitizing a subject to an agent This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermati... | 11/11/2008 |
| 7422890 | Therapeutic and prophylactic agents and methods of using the same A phospholipase A2 inhibitor protein designated “Phospholipase Inhibitor from Python” (PIP)—formerly designated “Python Antitoxic Factor” (PAF)—is given by SEQ ID NO:2. The partial amino acid sequence for PIP was initially determined from the ... | 09/09/2008 |
| 7399606 | Methods for identifying IκB Kinase (IKK) inhibitors The present invention provides methods and compositions for inhibiting IκB Kinase (IKK) as well as methods and compositions for identifying compounds with activity as inhibitors of IKK. In particular, the present invention provides methods for identifying inhibitor... | 07/15/2008 |
| 7399605 | Method for identifying a HCV RNA-dependent RNA polymerase inhibitor The present invention relates to the molecular biology and virology of the hepatitis C virus (HCV). An object of the present invention is a method to reproduce in vitro the RNA-dependent RNA polymerase activity of HCV that makes use of sequences contained in the HCV... | 07/15/2008 |
| 7396659 | Inhibitors of nitric oxide synthase to treat type 1 diabetes A method for treating type 1 diabetes in a human in need of such treatment, comprising administering to the human a biologically effective amount of at least one inhibitor of inducible nitric oxide synthase or a pro-inflammatory cytokine, wherein the inhibitor is an... | 07/08/2008 |
| 7384907 | Method of treating infection with ABl tyrosine kinase inhibitors The present invention relates to a method of preventing or treating a pathogen infection comprising administering to a mammal in need thereof an effective amount of an inhibitor of Abl tyrosine kinase. ... | 06/10/2008 |
| 7381537 | Use of inhibitors of glutaminyl cyclases for treatment and prevention of disease The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screeing for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for ... | 06/03/2008 |
| 7368551 | DNA cytosine methyltransferase genes, polypeptides and uses thereof De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, ... | 05/06/2008 |
| 7369946 | Method of identifying inhibitors of Tie-2 The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The inventi... | 05/06/2008 |
| 7364910 | Methods of inducing ovulation The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific admini... | 04/29/2008 |
| 7342108 | De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, ... | 03/11/2008 |
| 7335492 | Process for partitioning of proteins The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the a... | 02/26/2008 |
| 7326550 | Yeast strains for the production of lactic acid Yeast strains transformed with at least one copy of a gene coding for lactic dehydrogenase (LDH) and further modified for the production of lactic acid with high yield and productivities, are described. ... | 02/05/2008 |
| 7316912 | Tyrosylprotein sulfotransferases and methods of use thereof Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides an... | 01/08/2008 |
| 7314722 | Cytostatin II antibodies and methods The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention... | 01/01/2008 |
| 7311903 | Glycosylated human interferon alpha isoform The present invention relates to an amino acid-modified human interferon alpha isoform having at least one of the Asn-Xaa-Ser/Thr (N-X-S/T) sequence formed at a specific site so that glycosylation takes place at this site and a gene encoding the same, an expression ... | 12/25/2007 |
| 7311907 | Lentiviral packaging cells Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 12/25/2007 |
| 7306938 | High throughput screen for inhibitors of fatty acid biosynthesis in bacteria Methods for identifying compounds that are inhibitors of bacterial fatty acid biosynthesis are disclosed. Such compounds can be used as lead compounds in methods for preparing antibacterial agents for treating bacterial infections (e.g., in humans, animals, and plan... | 12/11/2007 |
| 7303885 | Screening method for candidate drugs The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macro... | 12/04/2007 |
| 7297514 | Method for preventing superoxide damage to cells and oxygen-labile proteins A method of reducing superoxide damage to a cell is disclosed. In one embodiment, this method comprises the step of engineering the cell to produce more than a native amount of the YggX protein or its homolog, wherein the cells are rendered more resistant to superox... | 11/20/2007 |
| 7285654 | Stimulus-inducible protein kinase complex and methods of use therefor Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify... | 10/23/2007 |
| 7285406 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to th... | 10/23/2007 |
| 7282325 | Method of preparing pharmaceutical compositions A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de n... | 10/16/2007 |
| 7279302 | Methods for identifying herbicidal compounds The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic path... | 10/09/2007 |
| 7276348 | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 10/02/2007 |
| 7270979 | DNA for expression of alpha 1-antitrypsin in methylotropic yeast Alpha 1-antitrypsin is prepared by growing in a fermentor methylotropic yeast transformants containing in their genome at least one copy of DNA encoding alpha 1-antitrypsin, in operational linkage with DNA encoding a signal sequence, which is effective for directing... | 09/18/2007 |
| 7271152 | Compounds and methods for the modulation of CD154 The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to m... | 09/18/2007 |
| 7264953 | Mutant proteinase-inhibitors and uses thereof A library of mutants of metastable proteins, such as proteinase inhibitors, can be screened for the specific loss of a wild-type capability to bind an antibody, yielding valuable drug-design information which otherwise is unavailable. By this approach, for example, ... | 09/04/2007 |
| 7264809 | Methods of inhibiting platelet activation and recruitment The present invention provides soluble CD39 polypeptides and compositions, and methods for inhibiting platelet activation and recruitment in a mammal comprising administering a soluble CD39 polypeptide. ... | 09/04/2007 |
