Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8187837 | Optimized purification process of recombinant growth factor protein A process for the production of a purified recombinant GDF-5 related protein in prokaryotes comprises the steps of bacterial cell disruption and inclusion body solubilization to obtain a solubilized monomer of a GDF-5 related protein, said process characterized by a... | 05/29/2012 |
| 8188039 | VEGF-D mutants and their use The present invention is a VEGF-D protein, containing one or more amino acid mutations at the dimer interface, and their use in therapy, particularly in the promotion of angiogenesis. ... | 05/29/2012 |
| 8187839 | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibod... | 05/29/2012 |
| 8187836 | Mammalian expression vectors and uses thereof The present invention features nucleic acids for recombinant protein expression in mammalian cell culture. The episomal vectors of the invention promote high protein production in mammalian cells expressing the SV40 T Ag or Epstein-Barr virus nuclear antigen (e.g., ... | 05/29/2012 |
| 8187838 | β-Galactoside-α2, 6-sialyltransferase, a gene encoding thereof, and a method for producing thereof The present invention provides a novel β-galactoside-α2,6-sialyltransferase having high productivity and/or high activity, and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase. The p... | 05/29/2012 |
| 8187835 | Method for producing protein By culturing a methanol-assimilating bacterium which harbors a DNA construct which contains a promoter sequence that functions in the methanol-assimilating bacterium and a nucleotide sequence that encodes a polypeptide containing a signal sequence and an objective p... | 05/29/2012 |
| 8187834 | Non-cytotoxic protein conjugates The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor pres... | 05/29/2012 |
| 8183012 | Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are al... | 05/22/2012 |
| 8183013 | Method for production of protein having non-natural type amino acid integrated therein This invention provides a method for producing proteins into which non-natural amino acids have been incorporated at desired positions involving the use of either prokaryote-derived or eukaryote-type aaRS* and prokaryotic cells or eukaryote-type as host cells, the m... | 05/22/2012 |
| 8183011 | RNA interferases and methods of use thereof The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase... | 05/22/2012 |
| 8178319 | Peptides and uses thereof The present invention relates to monovalent fucose-binding peptides. The peptides may be recombinantly produced or chemically synthesized. Preferably the peptides are derived from a lectin, in particular Aleuria aurantia lectin. Furthermore the invention rela... | 05/15/2012 |
| 8178317 | Compositions and methods for identifying transforming and tumor suppressor genes Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complemen... | 05/15/2012 |
| 8178318 | Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield Methods for controlling the level of dissolved carbon dioxide and limiting osmolality in a mammalian cell culture process to enhance cell growth, viability and density, and increase biologic product concentration and yield are provided. Such control of the level of ... | 05/15/2012 |
| 8173393 | Expanding the eukaryotic genetic code This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of... | 05/08/2012 |
| 8173394 | Systems and methods for protein production The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-enginee... | 05/08/2012 |
| 8173395 | Mussel bioadhesive The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a hybrid of MGFP-5 and foot protein type 1 (FP-1), where an adhes... | 05/08/2012 |
| 8173392 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 05/08/2012 |
| 8168409 | Compositions and methods relating to anti-IGF-1 receptor antibodies The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments ... | 05/01/2012 |
| 8168382 | Methods for detecting DNA originating from different individuals In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an... | 05/01/2012 |
| 8168411 | Highly thermostable fluorescent proteins Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the i... | 05/01/2012 |
| 8168408 | Cytolethal distending toxins and detection of bacteria using the same as a target The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by com... | 05/01/2012 |
| 8168407 | Method of synthesizing a suppressor TRNA, DNA construct and use thereof for producing a protein including a non-natural amino acid There are provided a DNA construct comprising non-eukaryote-derived suppressor tRNA gene containing no internal promoter functioning in a eukaryotic cell, and a eukaryote-derived or bacteriophage-derived promoter linked at the 5′ end of the tRNA gene, a method for... | 05/01/2012 |
| 8168410 | Anti-IGF-IR antibodies and uses thereof The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR receptor, especially monoclonal antibodi... | 05/01/2012 |
| 8163519 | Fungal immunomodulatory protein (FIP) prepared by microorganisms and uses thereof The invention relates to an improved nucleic acid molecule encoding fungal immunomodulatory protein (FIP) that is better expressed in fungi, to vectors comprising the nucleic acid molecule, to hosts transformed with said vectors, to processes of expressing the prote... | 04/24/2012 |
| 8158382 | UBP1 protease mutant and its coding sequence, their applications and heterogonous protein expression system Invention relates to novel and improved UBP1 protease mutants with a substitution at position (754), a deletion of amino-acids at position (1-54) and at least a portion of the amino-acids found at position (55-98) and their coding sequence as well as their applicati... | 04/17/2012 |
| 8158384 | Methods for reducing or eliminating α-mannosidase resistant glycans in the production of glycoproteins The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastor... | 04/17/2012 |
| 8158383 | Methods of generating protein variants The present invention provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypept... | 04/17/2012 |
| 8153398 | Polynucleotides encoding signal peptide-containing molecules The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diag... | 04/10/2012 |
| 8153399 | Methods and compositions for inactivating glutamine synthetase gene expression Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as... | 04/10/2012 |
| 8153397 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The methods of the invention can provide 1.1 g of the LC per liter of cul... | 04/10/2012 |
| 8148105 | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization ... | 04/03/2012 |
| 8148106 | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. T... | 04/03/2012 |
| 8148104 | Xylanase, microorganisms producing it, DNA molecules, methods for preparing this xylanase and uses of the latter The invention relates to a xylanase originating from a Bacillus strain. This xylanase is active over a wide range of acid and basic pH. The invention also relates to new strains of microorganisms producing this xylanase and to methods for preparing this xylan... | 04/03/2012 |
| 8148107 | High affinity human antibodies to human nerve growth factor A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affini... | 04/03/2012 |
| 8143023 | Method for methanol independent induction from methanol inducible promoters in A method for producing a polypeptide in a methylotrophic yeast host cell is described, where expression of the polypeptide is controlled by a methanol inducible promoter, including: i) expression of a positive regulator from a non-native promoter, the positive regul... | 03/27/2012 |
| 8143025 | Antibodies against vascular endothelial growth factor receptor-1 Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including seq... | 03/27/2012 |
| 8143024 | genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication p... | 03/27/2012 |
| 8143002 | Methods for isolating and characterizing endogenous mRNA-protein (mRNP) complexes Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex ... | 03/27/2012 |
| 8143022 | High production system for infectious hepatitis C virus particle The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5′ ... | 03/27/2012 |
| 8137929 | Basic protein purification tags from thermophilic bacteria The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The... | 03/20/2012 |
