Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8183010 | Cell-free synthesis of membrane bound polypeptides Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane-associated polypeptides. ... | 05/22/2012 |
| 8178316 | Evaluating proteins The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affin... | 05/15/2012 |
| 8163518 | Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry. ... | 04/24/2012 |
| 8153395 | Method of making activated carboxypeptidases The invention is related to a method for making an activated carboxypeptidase in a fungi cell comprising introducing a DNA sequence encoding a proform of the carboxypeptidase wherein a Kex2 site has been introduced in the prosequence of the carboxypeptidase, culturi... | 04/10/2012 |
| 8153396 | Method for producing a casein hydrolysate The present invention relates to a method for producing a casein hydrolysate using a microbial endopeptidase. ... | 04/10/2012 |
| 8124372 | Selective enzymatic amidation of C-terminal esters or acids of peptides The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease sub... | 02/28/2012 |
| 8124373 | Isomaltulose synthases, polynucleotides encoding them and uses therefor The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic ac... | 02/28/2012 |
| 8119364 | Methods for generating analogs of coenzyme A Methods to generate analogs of coenzyme A in vivo are disclosed. The methods to generate analogs of coenzyme A in a cell comprise reacting pantetheine or a derivative thereof with a reporter to form labeled pantetheine or a derivative thereof, contacting the cell wi... | 02/21/2012 |
| 8105802 | Method of producing microbial transglutaminase The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-struct... | 01/31/2012 |
| 8101377 | Protein hydrolysates and method of making Methods of making protein hydrolysates are described. The methods may include the steps of providing a solution comprising protein, and adjusting a pH of the solution to about 10.4 or more to form a basic protein solution. Additional steps may include adding a prote... | 01/24/2012 |
| 8088597 | Blood pressure lowering peptides from glycomacropeptide A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more -I-P-P- present than -V-P-P- (molar basis) which comprises hydrolysing the p... | 01/03/2012 |
| 8084227 | Method for producing dipeptides The present invention provides a method for producing a dipeptide from starting materials that are available at low costs through a route industrially advantageous and simple. Dipeptides are produced from amino acid esters and amino acids by using a culture of a mic... | 12/27/2011 |
| 8071331 | Method of producing amino acid metal chelates A method of producing amino acid metal chelates includes producing an amino acid ligand by enzymatically hydrolyzing bacterial cells, and reacting the amino acid ligand with a metal cation. ... | 12/06/2011 |
| 8067196 | 6-O sulfated polysaccharides and methods of preparation thereof Disclosed are methods of 6-O-sulfating glucosaminyl N-acetylglucosamine residues (GlcNAc) in a polysaccharide preparation and methods of converting anticoagulant-inactive heparan sulfate to anticoagulant-active heparan sulfate and substantially pure polysaccharide p... | 11/29/2011 |
| 8062862 | Hydrolysed egg proteins This invention relates to a process for the production of enzymatically hydrolysed egg proteins comprising a first hydrolysis step in which intact egg proteins are subjected to enzymatic hydrolysis by a first protease, an intermediate heating step in which the produ... | 11/22/2011 |
| 8058026 | Microorganism and protease decomposing proteins recalcitrant to proteolysis The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a proteas... | 11/15/2011 |
| 8034581 | Cell-free extract and glycoprotein synthesis system Insect cells are stored in a small gas cylinder, and the small gas cylinder is charged with nitrogen gas to pressurize the cylinder. The charged gas is exhausted at once to crush the cells to provide the objective cell extract with translation activity and glycosyla... | 10/11/2011 |
| 8034582 | Process for crosslinking proteins with a ketose containing 3 to 5 carbon atoms The present invention relates to a process for crosslinking proteins, according to which the crosslinking agent is a ketose containing 3 to 5 carbon atoms and said proteins are chosen from the group comprising proteins from animal tissues, from milk or from blood, s... | 10/11/2011 |
| 7981635 | Cleavage of precursors of insulins by a variant of trypsin The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their pr... | 07/19/2011 |
| 7977066 | Method for preparing tryptophan rich peptides Described is a method for selectively isolating tryptophan containing peptides from an aqueous peptide mixture, including the steps of controlling the pH of the aqueous peptide mixture to 4.0-6.0, forming a precipitate of tryptophan containing peptides, and isolatin... | 07/12/2011 |
| 7972808 | Protein hydrolysate rich in tripeptides The present invention describes a protein hydrolysate which is rich in tripeptides whereby the tripeptides are rich in proline at one end of the peptide. ... | 07/05/2011 |
| 7968310 | Tagged sialyltransferase proteins The present invention provides modified Campylobacter sialyltransferase proteins that exhibit enhanced expression as compared to its unmodified form. Nucleic acids that encode the sialyltransferase proteins are also included, as are methods to produce and use... | 06/28/2011 |
| 7943340 | Fungal dipeptidyl peptidase IV (DPPIV) enzyme for reagent use Disclosed herein are fungal nucleic acid sequences that encode novel dipetidyl peptidase IV (DPPIV) polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned p... | 05/17/2011 |
| 7943339 | Isolated nucleic acid molecules from the genome of citrus leprosis virus and uses thereof Disclosed are nucleic acids from the Citrus Leprosis Virus (CiLV) genome, associated with Citrus Leprosis (CiL) disease. Cloned CiLV nucleic acids can be used as probes or primers in assays for detecting CiLV in biological samples, particularly leaves, roots and oth... | 05/17/2011 |
| 7939293 | Method for producing carboxy-terminal-amidified peptides The invention relates to the production of carboxy-terminal (C-terminal) amidified peptides with C-terminal amidified lysin, in particular with the biological activity of GLP-1, the chemical and/or biotechnological precursors and intermediate products thereof. The i... | 05/10/2011 |
| 7932053 | Method for preparing modified collagen outside a host cell The present invention relates to a method for preparing a modified folded protein, comprising modifying unfolded a-chains comprising a collagenous amino acid sequence and thereafter folding at least part of the modified a-chains into a quaternary protein structure, ... | 04/26/2011 |
| 7932054 | Methods of using thermal tolerant avicelase from The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus cellulolyticus, and, like many cellulases, the disclosed polypeptide a... | 04/26/2011 |
| 7915008 | Methods for isolation and analysis of sialylated and phosphorylated peptides Changes in sialylation of cell surface or plasma proteins are often associated with various cancers and other disease conditions. Provided are methods of detecting biomarkers of conditions associated with a change of sialylation status. Sialylated peptides are first... | 03/29/2011 |
| 7888063 | Unnatural reactive amino acid genetic code additions This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of... | 02/15/2011 |
| 7871794 | Enhanced cell-free synthesis of active proteins containing disulfide bonds Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathion... | 01/18/2011 |
| 7871793 | Antimicrobial carbohydrates and methods of using same Compositions useful for inhibiting the growth of bacteria, including bacteria that can cause gastric ulcers, are provided. In addition, transgenic organism that can produce such compositions are provided. Methods of using the compositions to treat or prevent gastric... | 01/18/2011 |
| 7863015 | Method and device for carrying out biochemical reactions with a high throughput Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing e... | 01/04/2011 |
| 7858338 | Processing enzymes fused to basic protein tags The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying proteins. They can be produced in high yields and can be effectively ... | 12/28/2010 |
| 7858337 | Process for the manufacture of a composite material The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently... | 12/28/2010 |
| 7807405 | Glycoprotein synthesis and remodeling by enzymatic transglycosylation A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an ... | 10/05/2010 |
| 7794970 | Method for generating F(ab′)2 antibody fragments Methods for generating F(ab′)2 fragments from antibodies using thermolysin as well as F(ab′)2 fragments and compositions comprising F(ab′)2 fragments generated by the method are described. ... | 09/14/2010 |
| 7785825 | Compositions and methods for dehydration and cyclization of peptides, synthetic compounds, and lantibiotics Lantibiotics are synthesized on ribosomes as prepeptides and post-translationally modified to a mature form. These modifications include dehydrations and cyclizations. Compounds and related methods of generating compounds, modified by dehydration, cyclization, or de... | 08/31/2010 |
| 7785824 | Hydrolysed casein product comprising tripeptides IPP and/or VPP Process for the preparation of a hydrolysed casein product comprising tripeptides VPP, IPP and/or LPP, wherein a substrate comprising casein or casein fragments is subjected to enzyme treatment wherein the enzyme is derived from Aspergillus, wherein the enzym... | 08/31/2010 |
| 7785826 | Method for the deacylation of lipopeptides The invention relates to a method for the enzymatic elimination of the N-acyl side chain from lipopeptides to form the corresponding nucleus, wherein the lipopeptide is prepared by fermentation, the lipopeptide being bound to the cells of the biomass, and the biomas... | 08/31/2010 |
| 7767415 | Compositions and methods for modifying blood cell carbohydrates This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique αN-acetylgalactosamini... | 08/03/2010 |
