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| Number | Title | Issue Date |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7129344 | Nucleic acid isolation A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a chaotrope and water under conditions to denature the genomic DNA and reco... | 10/31/2006 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6750040 | Cell-free synthesis of polyketides Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both. ... | 06/15/2004 |
| 6288272 | Continuous process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives The present invention relates to a continuous process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives expressed by the following Formula 1 and more particularly, to the continuous process which enables preparing optically pure (S)-3... | 09/11/2001 |
| 6261766 | Detection of prostate-specific antigen in breast tumors This invention relates to the detection of prostate-specific antigen (PSA) in female breast tumor extract as a prognostic or predictive indicator for breast carcinoma. The presence of prostate-specific antigen in breast tumours is associated with earlier ... | 07/17/2001 |
| 6232443 | Renal nuclear matrix proteins, polynucleotide sequences encoding them, and their use Nuclear matrix proteins (NMP) are useful markers in diagnosing and monitoring the stage of malignancy of a cell, and in treating cell proliferative disorders associated with the NMP.... | 05/15/2001 |
| 6080555 | Synthesis of polyketides from diketides Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.... | 06/27/2000 |
| 5989903 | Strain for the production of 6-dimethyltetracycline, method for producing the strain and vector for use in the method Recombinant S. aureofaciens cells are provided. These cells comprise: (a) at least one CTC 11 gene; and (b) optionally (i) a CTC 09 gene; (ii) a CTC 03 gene; or (iii)a combination thereof; wherein: the CTC 11 gene is chromosomal, extra-chromosomal, or chromosomal and ... | 11/23/1999 |
| 5965429 | Strain for the production of 6-demethyltetracycline, method for producing the strain and vector for use in the method Recombinant S. aureofaciens cells are provided. These cells comprise: (a) at least one CTC 11 gene; and (b) optionally (i) a CTC 09 gene; (ii) a CTC 03 gene; or (iii) a combination thereof; wherein: the CTC 11 gene is chromosomal, extra-chromosomal, or chromosomal ... | 10/12/1999 |
| 5925531 | Human bone marrow endothelial cell line and methods of use thereof The present invention provides immortalized human bone marrow endothelial cells which are useful for the study of tumor metastasis. In particular, the human bone marrow endothelial cell lines provided by the invention provide an in vitro model system for ... | 07/20/1999 |
| 5840494 | Method for molecular staging of prostate cancer This invention provides a method of determining the stage of prostate cancer in a human subject using a sample of peripheral blood from a human subject. The invention uses reverse transcriptase-PCR to detect the mRNA encoding prostate specific antigen (PS... | 11/24/1998 |
| 5776748 | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor The disclosed invention is a device for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere cells which are isolated by cytophobic regions to which cell... | 07/07/1998 |
| 5589375 | PTP 1D: a novel protein tyrosine phosphatase A novel protein tyrosine phosphatase is the protein designated PTP 1D. The PTP 1D protein may be produced by recombinant means, for example using a nucleic acid construct encoding the protein as provided herein. Also disclosed is an antibody specific for ... | 12/31/1996 |
| 5217877 | Process for the preparation of -glucosidase inhibitor, pradimicin Q The present invention relates to a novel -glucosidase inhibitor, pradimicin Q, having the following formula ##STR1## and its pharmaceutically acceptable base salts.... | 06/08/1993 |
| 5183758 | Production of 7-chloro-3-methoxy-2'-N-methyltetracycline with Actinomadura brunnea An antibiotic complex is produced by the microorganism, Actinomadura brunnea NRRL 15216, ATCC 39216. A novel antibiotic 7-chloro-8-methoxy-2'-N-methyltetracycline, isolated from the antibiotic complex, is active against gram-positive and gram-negative aer... | 02/02/1993 |
| 5100921 | Angucyclinones from Streptomycetes, a process for the preparation thereof, and the use thereof New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.... | 03/31/1992 |
| 5066585 | Method of inhibiting fungus using novel antifungal compounds A new species of Micromonospora, in particular Micromonospora spartanea ATCC 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production, isolation and characterization of the compounds are described. ... | 11/19/1991 |
| 4977084 | Production, isolation, and identification of novel antifungal compounds A new species of Micromonospora, in particular Micromonospora spartanea ATCC 53803, is described. The species produces new antifungal compounds spartanamicins A and B. Methods for the production, isolation and characterization of the compounds are describ... | 12/11/1990 |
| 4752605 | 7-chloro-4a-hydroxy-8-methoxytetracycline, antibiotic compositions containing them and a method of using The antibiotic 7273 complex is elaborated by the microorganism, Dactylosporangium vescum ATCC 39499. The novel 7-chloro-4a-hydroxy-8-methoxytetracycline isolated from antibiotic 7273 complex is active against gram-positive and gram-negative aerobes.... | 06/21/1988 |
| 4385122 | Anthracycline antibiotics produced by streptosporangium fragile A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic co... | 05/24/1983 |
| 4123608 | Antibiotic compound A novel anthracycline antibiotic designated rudolphomycin is produced by fermentation of Actinosporangium sp. ATCC 31127 and isolation of the new antibiotic free of substances co-produced therewith. Rudolphomycin and its pharmaceutically acceptable salts ... | 10/31/1978 |
| 4116769 | Process for preparing 7-deoxysteffimycinol Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxyst... | 09/26/1978 |
| 4106994 | Process for producing steffimycinol Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxyst... | 08/15/1978 |
| 4077844 | Process for preparing steffimycinol Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxyst... | 03/07/1978 |
| 4071411 | Antitumor antibiotics aclacinomycins A and B [RD-9187A] New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as l... | 01/31/1978 |
| 4013515 | Process for the preparation of the antibiotic 20.798 R.P. 20,798 R.P., which has valuable anti-tumor properties, and acid addition salts thereof are prepared by the microbiological reduction of daunorubicin of the formula: ##SPC1## Or of an acid addition salt thereof, to convert the grouping --CO--CH3... | 03/22/1977 |
