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| Number | Title | Issue Date |
| 7257243 | Method for analyzing a biological sample A method for the analysis of a biological sample for determining a change thereof relative to a healthy biological sample includes creating a first image of the biological sample at a first acquisition modality and creating a second image of the biological samples a... | 08/14/2007 |
| 7217537 | Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase A method to increase carotenoid production in carotenogenic microbial host cells is provided by down-regulating or disrupting glycogen synthesis. Disruption of glycogen synthase activity in a carotenogenic microbial host cell significantly increased carotenoid produ... | 05/15/2007 |
| 7169580 | Protein having PGE2 synthase activity and use thereof A single protein which is the substance of the PGE2 synthesis activity in brain soluble fractions of LPS administered rats has been purified and identified. The protein has an activity of synthesizing PGE2 from PGH2, and further, has an activity of synthesizing PGE2... | 01/30/2007 |
| 7144710 | Method for detecting inflammation and inflammatory conditions Methods for detecting the inflammatory biomarkers molecule CD 163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in a patient and compositions and methods for preventing and treating in... | 12/05/2006 |
| 6846807 | Colorectal neoplasia prophylaxis Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal neoplasia; and (b) enterically delivering into the gut of the person an effec... | 01/25/2005 |
| 6713268 | Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation Methods to identify agents having ocular hypotensive activity which have reduced or absent ability to stimulate iridial hyperpigmentation are disclosed. The methods reside in part in detecting the ability of a test compound to interact with the FP receptor. ... | 03/30/2004 |
| 6261766 | Detection of prostate-specific antigen in breast tumors This invention relates to the detection of prostate-specific antigen (PSA) in female breast tumor extract as a prognostic or predictive indicator for breast carcinoma. The presence of prostate-specific antigen in breast tumours is associated with earlier ... | 07/17/2001 |
| 6214628 | Method of conducting an assay of a sample containing an analyte of interest In accordance with the present invention, a method of conducting an assay of a sample containing an analyte of interest includes the step of forming a mixture so as to bring a metal-ligand complex into interactive proximity with the sample containing the ... | 04/10/2001 |
| 6083501 | Drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation in the lung and model animals of the diseases A drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation, as well as a model animal of fibrinoid formation or thrombus formation in the lung is disclosed. The drug for preventing and treating diseases caused by fib... | 07/04/2000 |
| 6051395 | Method and compound for detecting low levels of microorganisms A method and compound for detecting low levels of microorganisms in biological samples is disclosed. In the method, an antibiotic is conjugated to a detectable label. This antibiotic/label conjugate is then introduced into a sample containing biological m... | 04/18/2000 |
| 5945295 | Method and compositions to detect autooxidation of lipids or fats ex vivo This invention relates to a method to assess food spoilage ex vivo by quantification of prostanoid compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.... | 08/31/1999 |
| 5925531 | Human bone marrow endothelial cell line and methods of use thereof The present invention provides immortalized human bone marrow endothelial cells which are useful for the study of tumor metastasis. In particular, the human bone marrow endothelial cell lines provided by the invention provide an in vitro model system for ... | 07/20/1999 |
| 5858696 | Method and compositions to assess oxidative stress in vivo This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F2 -like compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.... | 01/12/1999 |
| 5840494 | Method for molecular staging of prostate cancer This invention provides a method of determining the stage of prostate cancer in a human subject using a sample of peripheral blood from a human subject. The invention uses reverse transcriptase-PCR to detect the mRNA encoding prostate specific antigen (PS... | 11/24/1998 |
| 5700654 | Method and compositions to assess oxidative stress in vivo This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F2 -like compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.... | 12/23/1997 |
| 5508170 | Liquid thromboplastin reagent The invention is a stable liquid thromboplastin reagent used for measuring the performance of the coagulation system, with a shelf life of greater than 16 months, and a method of producing this reagent.... | 04/16/1996 |
| 5459239 | Peptide sequences and antipeptide antisera for detecting human cyclooxygenase-1 and cyclooxygenase-2 proteins This invention discloses novel immunogenic peptide sequences, derived from the human cyclooxygenase-1 and cyclooxygenase-2 cDNAs which elicit specific non cross-reactive antibody responses. Assays are also disclosed for selectively and independently detec... | 10/17/1995 |
| 5434086 | Method of testing potential cystic fibrosis treating compounds using cells in culture Cystic fibrosis (CF), a lethal genetic disease associated with a defect in Cl transport, is caused by mutations in the gene coding for cystic fibrosis transmembrane conductance regulator (CFTR). Surprisingly, not only wild type CFTR, but several naturally... | 07/18/1995 |
| 5403724 | Microbiological reduction of prostacyclin intermediate products with a 15-keto group A process for production of 15-alpha-hydroxyprostaglandin intermediates of formula I ##STR1## wherein X is CH2, A is trans --CH.dbd.CH-- B is ethylenedioxy or 2,2-dimethylpropylenedioxy, R1 is benzoyl, and R2 is ##STR... | 04/04/1995 |
| 5372935 | Detection of candida An alkaline solution containing a complex of C30 H31 ClN6 is used as a specific indicator for detecting the presence of Candida spp. When Candida yeast bodies are introduced into the indicator solution, the yeast bodies ar... | 12/13/1994 |
| 5358853 | Liquid thromboplastin reagent The invention is a stable liquid thromboplastin reagent used for measuring the performance of the coagulation system, with a shelf life of greater than 16 months, and a method of producing this reagent.... | 10/25/1994 |
| 4885246 | Optically active carbacyclin intermediates and processes for the preparation thereof New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic c... | 12/05/1989 |
| 4539333 | Prostacyclin, methods of using and method of making Prostacyclin, its salts, biosynthesis and synthesis thereof, pharmaceutical formulations containing them, and their use in medicine.... | 09/03/1985 |
| 4247635 | Microbiological reduction of 15-ketoprostaglandin intermediates A process for the preparation of a 15 -hydroxyprostaglandin intermediate of the formula ##STR1## wherein R1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms... | 01/27/1981 |
| 4202822 | 1-Hydroxymethyl-1-oxo-prostane derivatives of the F1 series Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the F1 series.... | 05/13/1980 |
| 4172839 | 1-Hydroxymethyl-1-oxo-prostane derivatives of the F2 series Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the F2 series.... | 10/30/1979 |
| 4170597 | 1-Hydroxymethyl-1-oxo-prostane derivatives of the E2 series Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E2 series.... | 10/09/1979 |
| 4164446 | Prostaglandin derivatives Novel 18.xi.-, 19.xi.- and 20.xi.-hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxy... | 08/14/1979 |
| 4088536 | Method for preparing prostaglandins Racemic 15-deoxo, 11,15-deoxy and other prostaglandins and methods for preparing the same. The initial reactant is lithium cyclopentadiene which is reacted with ethyl-7-bromoheptanoate to give the alkylated diene which in turn is oxygenated to a mixture o... | 05/09/1978 |
| 4082789 | Prostaglandins C2 This invention is a group of prostaglandin-like compounds of the formula: ##STR1## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH2 CH2 -- or X is cis--CH.dbd.CH-- and Y is --CH2 CH2 | 04/04/1978 |
| 4070242 | Method for the preparation of prostaglandin synthetase A method for the preparation of purified prostaglandin synthetase from bovine seminal vesicles is disclosed. The method includes the steps of homogenizing bovine seminal vesicles with a liquid medium to form an homogenate and centrifuging the homogenate a... | 01/24/1978 |
| 4058664 | Prostaglandin C3 This invention is a group of prostaglandin-like compounds of the formula: ##STR1## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH2 CH2 -- or X is cis-CH.dbd.CH-- and Y is --CH2 CH2 | 11/15/1977 |
| 4054595 | 18 OR 19 Hydroxy prostaglandins Novel 18 -, 19 - and 20 -hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and th... | 10/18/1977 |
| 4036876 | 18- AND 19-Hydroxylated prostaglandins Novel 18.xi.-hydroxylated and 19.xi.-hydroxylated prostaglandins and novel microbiological process for the production thereof.... | 07/19/1977 |
| 4031129 | 15-Deoxy-PGE1 and method for preparing same Racemic 15-deoxy, 11,15-deoxy and other prostaglandins and methods for preparing the same. The initial reactant is lithium cyclopentadiene which is reacted with ethyl-7-bromoheptanoate to give the alkylated diene which in turn is oxygenated to a mixture o... | 06/21/1977 |
| 3968141 | Processes for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one A method for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one which comprises asymmetrically reducing 2-substituted cyclopentane-1,3,4-trione to the corresponding 2-substituted-4(R)-hydroxy-cyclopentane-1,3-dione, enolizing ... | 07/06/1976 |
| 3930952 | Microbiological reduction of PGA.sub.2 and 15-epi PGA.sub.2 Reduction of 7(2-[(3R and 3S)-3-hydroxy-1-octenyl]-5-oxo-3-cyclopenten-1-yl)-5-heptenoic acid by microorganisms of the genera Streptomyces, Pseudomonas and Corynebacterium is disclosed. The products 7-(2-[(3R)-3-hydroxy-1-octenyl]-5-oxo-cyclopentyl)-... | 01/06/1976 |
