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| Number | Title | Issue Date |
| 8114589 | Self-addressable self-assembling microelectronic integrated systems, component devices, mechanisms, methods, and procedures for molecular biological analysis and diagnostics A method for electronically stabilizing hybridization of nucleic acids bound at a test site of a microelectronic device is described. First and second negatively charged nucleic acids are provided, the second nucleic acid being bound to the test site. A zwitterionic... | 02/14/2012 |
| 8114588 | Method for detecting vesicoureteral reflux or interstitial cystitis This invention provides a novel marker of vesicoureteral reflux or interstitial cystitis and a simple and non-invasive method for detecting vesicoureteral reflux or interstitial cystitis. This method comprises detection of uroplakin expression in a sample obtained f... | 02/14/2012 |
| 8114590 | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL, particularly, PDE7B and/or PDE3B, and a ra... | 02/14/2012 |
| 8114587 | Methods for the detection of colorectal cancer This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated ... | 02/14/2012 |
| 8105770 | Method of detecting amplification or deletion in genomic DNA Fragment [PROBLEMS] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity. [MEANS FOR SOLVING PROBLEMS] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-orig... | 01/31/2012 |
| 8105769 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensit... | 01/31/2012 |
| 8105768 | Methods of identifying patients for treatment with HER-2/neu inhibitors based on detection of HER-2/neu and TOP2A gene copy number The present invention provides methods for identifying cancer patients susceptible to effective treatment with trastuzumab and other medications that function similarly to trastuzumab. The invention is based on the discovery that certain chromosomal abnormalities ca... | 01/31/2012 |
| 8101345 | Proinflammatory nucleic acids The present invention provides compositions and methods for identifying and utilizing proinflammatory nucleic acids. In particular, this invention relates to compounds, particularly oligonucleotides, which exert their effect through triggering receptors expressed by... | 01/24/2012 |
| 8101343 | Delivery of dsRNA to arthropods The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the metho... | 01/24/2012 |
| 8101344 | Device and method for high-throughput quantification of mRNA from whole blood Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to olig... | 01/24/2012 |
| 8101346 | Identifier and nucleic acid amplification method of verification using the same There is provided an identification technique that can consistently maintain a set of information specifying a specimen through all the processes from the amplification process to the detection process of a specific sequence. A base sequence incorporating as a set o... | 01/24/2012 |
| 8101347 | Method and compositions for immunization with the V antigen A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV antigen. ... | 01/24/2012 |
| 8097405 | Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs A process for determining the sequence of nucleic acids of interest employs nucleotides or nucleotide analogs that have been made detectable by non-radioactive modifying or labeling. Such nucleotides or nucleotide analogs are modified on the sugar moieties, the phos... | 01/17/2012 |
| 8097409 | Kits for detecting group B Compositions, methods and kits for detecting Group B streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group B streptococci nucleic acids. ... | 01/17/2012 |
| 8097407 | Metastatic human tumor associated molecule, methods to detect both activated gene and protein and to interfere with gene expression This disclosure characterizes the function and the expression of the human protein encoded by tm9sf4. The protein is highly expressed in malignant tumor cells and therefore is a novel marker for malignancy. Moreover, the protein is involved in the phagocytotic chara... | 01/17/2012 |
| 8097408 | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter “TARGETS”) and fragments thereof, expression inhibi... | 01/17/2012 |
| 8097406 | Associations of single nucleotide polymorphisms and haplotype with feed intake and feed efficiency in beef cattle The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention... | 01/17/2012 |
| 8092994 | Human virus causing respiratory tract infection and uses thereof The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovir... | 01/10/2012 |
| 8092995 | Expressed pseudogene regulates gene expression Selective expression of a pseudogene of myosin light chain kinase is found in cancer cells and tissues but not in normal cells and tissues. The pseudogene is expressed, and when expressed it inhibits expression of the ancestral myosin light chain kinase. This widesp... | 01/10/2012 |
| 8092991 | De novo enzymatic production of nucleic acid molecules The present invention relates to methods for making a nucleic acid molecule and methods for ligating oligonucleotides. The method includes ligating a first at least partially double-stranded oligonucleotide that has a first and second single-stranded overhang to a s... | 01/10/2012 |
| 8092992 | Transcriptional regulation of gene expression by small double-stranded modulatory RNA The invention provides a method for modulating gene expression by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes, wherein the associati... | 01/10/2012 |
| 8092993 | Hydrogel thin film for use as a biosensor The present disclosure provides a biosensor capable of producing an indicator response upon detection of the presence of certain metabolites in a biological sample. The biosensor includes a hydrogel that is functionalized with affinity molecules specific to markers ... | 01/10/2012 |
| 8088572 | Polynucleotides for the detection of O157:H7 and O157:NM verotoxin producers Polynucleotide primers and probes for the specific detection of E. coli 0157:H7 and/or E. coli 0157:NM which produces verotoxin in samples are provided. The primers and probes can be used in real time diagnostic assays for rapid detection of E. coli... | 01/03/2012 |
| 8088575 | Massive parallel method for decoding DNA and RNA This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction.... | 01/03/2012 |
| 8088574 | Poly(A) polymerase The present invention relates to novel poly(A) polymerases and their use in the treatment of diseases, disorders and conditions. More specifically, the poly(A) polymerases of the present invention include polymerases which are directly modulated by components of the... | 01/03/2012 |
| 8088573 | Methods and devices for performing chemical reactions on a solid support Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top o... | 01/03/2012 |
| 8084199 | Method of diagnosing poor survival prognosis colon cancer using microRNA-21 The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. ... | 12/27/2011 |
| 8084197 | Identification of molecular sequence signatures and methods involving the same Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving... | 12/27/2011 |
| 8084201 | Fluorescent molecule It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being active for a long period of time) and highly sensitive, and which enables ... | 12/27/2011 |
| 8084202 | Optical detection for electronic microarrays Embodiments of the invention provide methods for detecting molecular recognition events electronically and optically. Methods according to embodiments of the invention provide a nucleic acid molecule that hybridizes to a first probe nucleic acid molecule attached to... | 12/27/2011 |
| 8084198 | Use of a GIP promoter polymorphism The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.... | 12/27/2011 |
| 8084200 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 12/27/2011 |
| 8080371 | Markers for addiction Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are ... | 12/20/2011 |
| 8080372 | Method for detecting nucleic acid in sample, method for designing probes, system for designing probes therefor Accurate detection of a target microorganism from a sample, which may contain a plurality of microorganisms, is intended. This can be realized by eliminating a possibility of cross-hybridization of a microorganism with other probes, which can accelerate the designin... | 12/20/2011 |
| 8076071 | Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided. ... | 12/13/2011 |
| 8076070 | Genome-wide chromosome conformation capture The invention relates to the use of GCC (Genome Conformation Capture) technology in determining the three dimensional arrangement of an entire genome. ... | 12/13/2011 |
| 8076072 | Nucleic acid labeling compounds Nucleic acid labeling compounds including the following are disclosed: These compounds are useful for attaching a detectable label to a nucleic acid. ... | 12/13/2011 |
| 8076063 | Multiplexed methylation detection methods The present invention is directed to sensitive and accurate multiplexed assays for target analyte detection and detection of methylation in nucleic acid samples. ... | 12/13/2011 |
| 8076306 | Compositions and their uses directed to hepcidin Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or treating anemia. Also provided are methods for prevention, amelioration or treatment of anemia, and for incr... | 12/13/2011 |
| 8076064 | Method of treatment of RNA sample The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with an analogous DNA set to provide a DNA/RNA duplex. The analogous DNA set includes at least one sequence analogous to a small RNA. The ... | 12/13/2011 |
