Class 435/58 - Hydroxylating

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Processes wherein a carbon atom on the substrate nucleus
No. of patents: 45
Last issue date: 08/18/2009

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Number	Title	Issue Date
7575892	Expression vector encoding a triterpene hydroxylase polypeptide Soyasapogenol B is biosynthesized via two steps of hydroxylation reaction of its precursor β-amyrin. However, the gene of the hydroxylase concerned in this reaction has not been revealed. Therefore, it was impossible to apply a genetic engineering technique on the ...	08/18/2009
7405057	Cytochrome P450s and uses thereof The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of ...	07/29/2008
7300771	Process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-Δ6-pregnanes A process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-Δ6-pregnanes is disclosed. ...	11/27/2007
7033779	Method for preparing steroids modified by yeast fermentation The invention concerns a novel method for producing hydroxylated and/or acetylated steroid comprising steps which consist in: culturing yeasts on a medium comprising at least a precursor of such hydroxylated and/or acetylated steroids; then isolating the hydroxylate...	04/25/2006
7002028	5-androsten-3β-ol steroid intermediates and processes for their preparation The present invention provides 5-androsten-3β-ol steroid intermediates and processes for their preparation. ...	02/21/2006
6933395	PROCESSING FOR PRODUCING OF DROSPIRENONE (6β, 7β, 15β, 16β-DIMETHYLENE-3-OXO-17α-PREGN-4-EN-21, 17-CARBOLACTONE, DRSP) AS WELL AS 7α-(3-HYDOXY-1-PROPLY)-6β, 7β; 15β, 16β-DIMETHYLENE-5β-ANDROSTANE-3β, 5,17β-TRIOL(ZK 92836) AND 6β, 7β; 15β, 16β-DIMETHYLENE-5β-HYDROXY Process for the production of drospirenone (6β,7β; 15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7α-(3-hydroxy-1-propyl)-6β,7β; 15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (ZK 92836) and 6β,7β; 15β,16β-dimethylene-...	08/23/2005
6933383	Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for e...	08/23/2005
6828120	Process to prepare 11β, 17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate The present invention is a novel process for the transformation of 17α-hydroxy-6α-methylpregn-4-ene-3,20-dione 17-acetate (I) to 11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate (VI)	12/07/2004
6632633	Process for oxidation of steroids and genetically engineered cells used therein An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins of catalyzing an oxidation step in the biological p...	10/14/2003
6605591	Treatment of subnormal bone mineral density A method of treating an individual to increase the individual's bone mineral density (BMD) is disclosed. The method includes co-administering a calcitonin-like agent and a DHEA-like agent. Also disclosed are methods for potentiating the effect of treatmen...	08/12/2003
6579693	Genetically engineered yeast strains Yeast strains expressing human genes coding regulating cytochrome P450 expression, a method for making same and applications thereof are described....	06/17/2003
6156946	Biological activation of aromatics for chemical processing and/or upgrading of aromatic compounds, petroleum, coal, resid, bitumen and other petrochemical streams The present invention is a process for transforming aromatic organic compounds and resource materials. The process includes the steps of contacting an organic material selected from the group consisting of single and/or multi-ring aromatic compounds and a...	12/05/2000
6043050	Biological process for producing steroids hydroxylated at the 25-position A biological process for producing steroids hydroxylated at the 25-position thereof comprises adding steroids (excluding cholesterol) to the cells or culture liquid of a microorganism of the genus Amycolata or Sphingomonas capable of hydroxylating the ste...	03/28/2000
5989855	Bile acid converting microorganism and process for preparing bile acid A microorganism having a capability of introducing a 7ଲ-hydroxyl group into a 7-unsubstituted bile acid, and a process for preparing a bile acid having a 7ଲ-hydroxyl group characterized by bringing the above microorganism into contact with a 7...	11/23/1999
5863746	Method of measuring bilirubin An assay for detecting in a test sample, an analyte that undergoes auto-oxidation is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an aqueous medium (i) a sample containing the analyte and (ii) a stabilizer that re...	01/26/1999
5384419	Preparation process for 20-keto-21(S) hydroxy steroid compounds and intermediates An improved process for the preparation of 20-keto-21(S)-hydroxy steroids of the Formula ##STR1## wherein R1 is alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 12 carbon atoms, and R3 is alkyl of 1 to 4 carbon atoms...	01/24/1995
5378611	Process for producing 6ଲ,14଱-dihydroxy-4-androstene-3, 17-dione amid 14଱-hydroxy-4-androstene-3,6,17-trione from 4-androstene-3, 17-dione using myrothecium sp. ferm bp-4432 The invention provides a novel process for the production of 6ଲ,14଱-dihydroxy-4-androstene-3,17-dione which comprises culturing a microorganism belonging to the genus Myrothecium and capable of hydrolyzing 4-androstene-3,17-dione to produce ...	01/03/1995
5298398	Preparation of 9-଱-hydroxy-17-keto steroids using Mycobacterium species CBS 482.86 9଱-hydroxy-17-keto steroids are prepared by fermenting steroids having a C-17-side chain of 5-10 carbon atoms inclusive, with the novel Mycobacterium species CBS 482.86. Starting from various substrates containing a 5-10 C carbon chain on C-17, ...	03/29/1994
5183749	Microbial process for the preparation of milbemycin derivatives The present invention relates to a one-step microbial process for the preparation of 13ଲ-hydroxy- or 14,15-epoxy-milbemycins of the following formulae I and II ##STR1## in which R1 and R1 ' represent methyl, ethyl, isoprop...	02/02/1993
5164302	Method for preparing 7ଲ-hydroxy-4-pregnene-3,20-dione derivatives Novel 7ଲ-hydroxy-4-pregnene-3,20-dione derivatives are disclosed. The group of these compounds has possibility of being utilized as an intermediate for the synthesis of progesterone derivatives having ovulation-inhibiting activity. These compounds themse...	11/17/1992
4997755	HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) A microbiological process is described for the preparation of 6-desmethyl-6-ଲ-hydroxymethyl and 6-desmethyl-6-ଲ-carboxylovastatin derivatives and 8-acyl analogs thereof....	03/05/1991
4975368	Novel androst-4-ene-3,17-dione derivatives and method for preparing same Novel androst-4-ene-3,17-dione derivatives are disclosed. The group of these compounds has biological activities, in particular, the inhibiting activity on human placenta-derived estrogen-synthesizing enzyme. Therefore these compounds are expected to be u...	12/04/1990
4604353	Method for producing conjugated ursodeoxycholic acids by means of microbial transformation A one step method of producing conjugated ursodeoxycholic acids from conjugated lithocholic acids by means of microbial transformation which comprises subjecting the conjugated lithocholic acids to the action of microorganisms which belong to Mortierella ...	08/05/1986
4579819	Method for production of ursodeoxycholic acid by means of microbial transformation A one-step method of producing ursodeoxycholic acid by means of microbial transformation which comprises subjecting lithocholic acid to the action of a ursodeoxycholic acid producing microorganism....	04/01/1986
4528271	Process for the intensification of microbiological conversions of steroids using cyclodextrin additives Microbiological conversions of cyclodextrins are intensified by adding to the reaction mixture 0.2 to 3 moles of ଱-, ଲ- or γ-cyclodextrin or an optical mixture thereof pro mole of the steroid substrate, before, at the beginning or during the ...	07/09/1985
4429041	Process of producing 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid The subject invention concerns a novel one-stage fermentation process for making the useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid (I). This process is significantly superior to the best prior art process known for ma...	01/31/1984
4425429	Composition of matter and process The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids....	01/10/1984
4416985	Process for preparing 3ଲ,7ଲ-dihydroxy-Ɗ⁵ -steroids A process for preparing a 3ଲ,7ଲ-dihydroxy-Ɗ5 steroid of the formula ##STR1## wherein Q is ##STR2## and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzy...	11/22/1983
4397947	Microbial process for 9଱-hydroxylation of steroids Valuable 9଱-hydroxy steroids are prepared via microbial enzymatic oxidation (MEO) by conventional fermentation means, without the need for a Ɗ1 dehydrogenation inhibitor, utilizing novel microorganism Nocardia canicruria ATCC 31548. Also...	08/09/1983
4379842	Process for the manufacture of 1଱-hydroxydehydroepiandrosterone The invention relates to a process for producing 1଱-hydroxydehydroepiandrosterone by fermenting or reacting dehydroepiandrosterone or a derivative thereof with microorganisms of the species Penicillium oxalicum or Aspergillus terreus or mycelium or ...	04/12/1983
4368264	Fermentation methods of preparing ergostadientriols The present invention concerns ergostadientriols which may be recovered from either the fungus R. oligosporus or the fungus R. oryzae as well as from soybeans which have been fermented with either of these fungi. Alternatively, the sterols may be chemical...	01/11/1983
4336332	Process for the manufacture of hydroxylated steroids The invention relates to a process for producing 7଱ -hydroxylated steroids by fermenting or reacting a steroid to be hydroxylated with microorganisms of the genus Botryodiplodia or enzyme extracts thereof until hydroxylation occurs. The i...	06/22/1982
4303754	Method for obtaining 7ଲ hydroxy steroids Method of producing steroids having a 7ଲ-OH substituent which comprises subjecting a steroid having a B-ring structure of the formula, ##STR1## wherein X is OH; Y is H, and when taken together X and Y is oxo (O.dbd.), to the action of a microor...	12/01/1981
4301246	Process for chenodeoxycholic acid production A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol ଲ-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alp...	11/17/1981
4284720	Process for the preparation of 19-hydroxy steroids of the androstane and pregnane series 10-Methyl steroids of the androstane or pregnane series are converted to the corresponding 19-hydroxy steroid by fermentation with a fungal culture of the genus Nigrospora....	08/18/1981
4246346	Antibiotic and steroid transformation process A method for activating immobilized living microorganisms applied to transformations of steroids, antibiotics and other compounds characterized by the addition of peptone, glucose or a mixture of peptone and glucose to the reaction mixture....	01/20/1981
4237220	Process for preparing 9଱-hydroxy-4-androstene-3,17-dione A high yield process for preparing 9଱-hydroxy-4-androstene-3,17-dione comprises fermenting 4-androstene-3,17-dione with a culture of Corynespora cassicola ATCC 16,718....	12/02/1980
4223092	Process for preparing 9଱-OH BN acid methyl ester Valuable steroid intermediates, 9଱-hydroxyandrost-4-ene-17ଲ-ol-3-one (9଱-OH testosterone), 9଱-hydroxy-3-ketobisnorchol-4-en-22-ol (9଱-OH BN alcohol) and 9଱-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9³...	09/16/1980
4220716	Process for the preparation of 7଱-hydroxylated steroids A fermentation process for the preparation of 7଱-hydroxylated steroids utilizing strains of the genus Mucor is disclosed. The 7଱-hydroxylated steroids are useful intermediates for the synthesis of chenodeoxycholic acid as well as steroidal hor...	09/02/1980
4214052	Process for preparing 9଱-OH BN alcohol Valuable steroid intermediates, 9଱-hydroxyandrost-4-ene-17ଲ-ol-3-one (9଱-OH testosterone), 9଱-hydroxy-3-ketobisnorchol-4-en-22-ol (9଱-OH BN alcohol) and 9଱-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9³...	07/22/1980

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Class 435/58 - Hydroxylating