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| Number | Title | Issue Date |
| 7226778 | Apparatus for natural recycling of protein waste An apparatus and process for naturally recycling poultry carcasses for use as a nutritional supplement, the apparatus generally consists of four modules: an enzymatic digest medium mixing assembly that self adjusts for pH; a mobile grinding assembly mounted on a tru... | 06/05/2007 |
| 7015060 | Cloverleaf microgyroscope with through-wafer interconnects and method of manufacturing a cloverleaf microgyroscope with through-wafer interconnects The present invention relates to a method of manufacturing a cloverleaf microgyroscope containing an integrated post comprising: attaching a post wafer to a resonator wafer, forming a bottom post from the post wafer being attached to the resonator wafer, preparing a... | 03/21/2006 |
| 6964865 | Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for β-lactam antibiotic biosynthesis DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthe... | 11/15/2005 |
| 6815189 | Gene from acremonium chrysogenum encoding a protein with cephalosporin C acetylhydrolase activity and methods of use of such gene An isolated DNA sequence that encodes a peptide with CPC-acetylhydrolase enzymatic activity is disclosed. Also, a method of expressing CPC-acetylhydrolase activity that includes the steps of (a) providing a microorganism that is susceptible to transformation with th... | 11/09/2004 |
| 6630338 | Removing deacetylase contaminant from cephalosporin C acylase using cationic surfactant An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A deacetylase contaminant is separated from Cephalosporin C acylase using a cationic s... | 10/07/2003 |
| 6518039 | Process for the fermentative production of deacylated cephalosporins The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.... | 02/11/2003 |
| 6503727 | Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the... | 01/07/2003 |
| 6465233 | Nucleic acid molecule encoding a cephalosporin acetylesterase The present invention relates to a nucleic acid molecule which codes for the cephalosporin acetylesterase from Bacillus subtilis ATCC 6633 (DSM 11909), vectors and host cells which comprise such a nucleic acid molecule, a process for the recombinant prepa... | 10/15/2002 |
| 6458558 | Process for the preparation of ଲ-lactam derivatives A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for example according to the procedures disclosed in U.S. Pat. No.... | 10/01/2002 |
| 6410259 | Process for the fermentative production of deacylated cephalosporins The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.... | 06/25/2002 |
| 6383772 | Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms. Lactams, for example 6-aminopenicillanic acid (6-APA), may be ... | 05/07/2002 |
| 6319684 | Process for the fermentative production of cephalosporin The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the presence of a side chain precursor, extraction of the N-s... | 11/20/2001 |
| 6165758 | Purifying cephalosporin C acylase and regenerating a carrier immobilizing cephalosporin C acylase An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A carrier containing an immobilized enzyme is regenerated by using a protease to remov... | 12/26/2000 |
| 6071713 | Bioprocesses for preparing 7-ACA and 7-ADAC A bioprocess for preparing adipoyl-7-ACA comprising the steps: (a) transforming cells of a strain of Penicillium chrysogenum which produces isopenicillin N with an expression vector containing DNA encoding an enzyme, having expandase activity capable of a... | 06/06/2000 |
| 6020151 | Process for the production of 7-ADCA via expandase activity on penicillin G A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.... | 02/01/2000 |
| 6017726 | Bioprocesses for preparing 7-ACA and 7-ADAC A process for making 7-aminodeacetyl-cephalosporanic acid (7-ADAC).... | 01/25/2000 |
| 5804429 | Cephalosporin C acylase A mutant CC acylase wherein at least one amino acid at the Ala49, Met164, Ser166, Met174, Glu358, Met465, Met506, or Met750 position of the amino acid sequence of the ... | 09/08/1998 |
| 5795733 | Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acy... | 08/18/1998 |
| 5780260 | Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an immobilized enzyme having a specific volume activity of at ... | 07/14/1998 |
| 5753458 | Acylation method for penicillins and cephalosporins A method for providing a semisynthetic ଲ-lactam antibiotic by enzyme catalyzed acylation of the parent ଲ-lactam with an activated derivative of the side chain acid wherein a modulator, which consists of one or more compounds different from the... | 05/19/1998 |
| 5731165 | Process for the production of 7-ADCA via expandase activity on penicillin G An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.... | 03/24/1998 |
| 5726032 | Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expan... | 03/10/1998 |
| 5677141 | Process for producing 7-aminocephem compound or salts thereof The present invention provides a process for producing 7-aminocephem compounds or salts thereof. 7-Aminocephem compounds are produced via microorganisms transformed with a vector containing a gene capable of converting a cephalosporin compound of the form... | 10/14/1997 |
| 5641753 | 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives combined with sulfisoxazole Pharmaceutical compositions of an erythromycin derivative combined with sulfisoxazole according to the structural formulas: ##STR1## where R is hydrogen, C1-C10 alkylcarbonyl or C1-C10 alkyl wherein the substituent is amino or cyano; R1 and R2 are in... | 06/24/1997 |
| 5629171 | Recombinant bioprocess for the preparation of 7-amino cephalosporanic acid (7-ACA) Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in... | 05/13/1997 |
| 5559005 | Bioprocess for preparing 7-ACA and 7-ADAC Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in... | 09/24/1996 |
| 5512454 | Enzymatic acylation of 3-hydroxymethyl cephalosporins O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an ora... | 04/30/1996 |
| 5424196 | Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives Transformation of Cephalosporin C or its derivatives and salts into 7-aminocephalosporanic acid or its derivatives by an enzymatic two stage process with enzymes immobilized on a solid matrix.... | 06/13/1995 |
| 5399685 | Process for the preparation of 20-keto-21 alpha-01-steroids A process for the preparation of a compound of the formula ##STR1## wherein R1 is alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 12 carbon atoms, R3 is alkyl of 1 to 4 carbon atoms comprising reacting a compound of... | 03/21/1995 |
| 5354667 | Process for the enzymatic preparation of 7-aminocephalosporanic acid A process for the production of an E. coli strain producing high yields of 7ଲ-(4-carboxybutanamido) cephalosporin acylase, comprises: (a) digesting the DNA of a microorganism whose DNA includes the sequence encoding 7ଲ-(4-carboxybutanamido) ce... | 10/11/1994 |
| 5336613 | Cephalosporin C acylase The present invention concerns a mutant cephalosporin C acylase derived from a precursor of the formula: A1-268 --X1 --Tyr--X2 --A272-304 --X3 --A306-773 (SEQ ID NO:1), wherein: A1-268 | 08/09/1994 |
| 5332663 | Process for the enzymatic preparation of 7-amino-cephalosporanic acids 7-amino-cephalosporanic acids having the formula ##STR1## are obtained by submitting compounds having the following formula to enzymatic conversion: ##STR2## wherein R represents H, OH, O--CO--R", R" being an alkyl radical with from 1 to 4 ... | 07/26/1994 |
| 5318896 | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) An important intermediate for preparing cephalosporin antibiotics, 7-aminodesacetoxy cephalosporanic acid (7-ADCA), is prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock... | 06/07/1994 |
| 5296358 | Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412 The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1 to 4 carbon atoms, is carried out by the ... | 03/22/1994 |
| 5246863 | Karl Fischer titration techniques An improved technique and apparatus for automatic titration for determining the water content of a sample by a Karl Fischer (K.F.) reaction. Rather than requiring titration from one endpoint to another identical endpoint, each determination is made using ... | 09/21/1993 |
| 5192678 | Cephalosporin C acylase A cephalosporin C acylase from Pseudomonas diminuta N-176 is disclosed as well as the recombinant production of this enzyme in E. coli. The enzyme is characterized by the ability to catalyze the conversion of cephalosporin C, gultaryl 7-ACA, apidyl 7-ACA,... | 03/09/1993 |
| 5079146 | Method of protection of the carboxy groups in the chemistry of ଲ-lactam compounds The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of ଲ-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetox... | 01/07/1992 |
| 4981789 | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase derived from Arthroba... | 01/01/1991 |
| 4774179 | Process for preparing a 7-aminocephalosporanic acid compound A process for preparing a 7-aminocephalosporanic acid compound which comprises treating a cephalosporin C compound with an enzyme-producing microorganism belonging to the genus Pseudomonas or a material obtained by subjecting the microorganism to chemical... | 09/27/1988 |
| 4316958 | Process for producing optically active cephalosporin analogs Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.... | 02/23/1982 |
