Class 435/50 - By acylation of the substituent in the 7-position

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Processes wherein the product synthesized is prepared by
No. of patents: 24
Last issue date: 12/06/2011

Number	Title	Issue Date
8071330	Process for the synthesis of cefaclor The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D-phenylglycine in activated form (PGa) in the presence of an enzyme in a reaction mixture to form cefaclor...	12/06/2011
7588913	Process for the preparation of cephradine The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephra...	09/15/2009
7241630	Paramagnetic particle detection A method of determining the number of magnetic particles within a sample using a tuned circuit having a capacitor and a coil. The method comprises: a. determining the difference in the resonant frequency of the tuned circuit when t...	07/10/2007
6942990	Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203 The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-β-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic ac...	09/13/2005
6518039	Process for the fermentative production of deacylated cephalosporins The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts....	02/11/2003
6503727	Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the...	01/07/2003
6319684	Process for the fermentative production of cephalosporin The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the presence of a side chain precursor, extraction of the N-s...	11/20/2001
6287799	Process for the preparation of aଲ-lactam antibiotic Process for the preparation of a ଲ-lactam antibiotic in which a ଲ-lactam nucleus is subjected to an enzymatic acylation reaction with the aid of an acylation agent at a molar ratio of acylation agent/ଲ-lactam nucleus of less than 2.5, wi...	09/11/2001
6218138	Synthesis of beta-lactam antibiotics with immobilized penicillin amidase Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase from E. coli covalently immobilized on support particles. T...	04/17/2001
6060268	Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer Penicillin G acylase is immobilized by covalent bonding to a crosslinked mixture of a gelled gelling agent such as gelatin and a polymer containing free amino groups such as alginate amine, chitosan or polyethylene imine. The immobilized penicillin G acyl...	05/09/2000
5874571	Process for the recovery of cephalexin The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin be...	02/23/1999
5780260	Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an immobilized enzyme having a specific volume activity of at ...	07/14/1998
5753458	Acylation method for penicillins and cephalosporins A method for providing a semisynthetic ଲ-lactam antibiotic by enzyme catalyzed acylation of the parent ଲ-lactam with an activated derivative of the side chain acid wherein a modulator, which consists of one or more compounds different from the...	05/19/1998
5525483	Process for preparation of ଲ-lactams utilizing a combined concentration of acylating agent plus ଲ-lactam derivative of at least 400 mm ଲ-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino ଲ-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of ଲ-lactam derivative in the reaction mix...	06/11/1996
5512454	Enzymatic acylation of 3-hydroxymethyl cephalosporins O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an ora...	04/30/1996
5470717	Method for the preparation of certain ଲ-lactam antibiotics The present invention relates to an improved method for the preparation of certain ଲ-lactam antibiotics by enzymatic acylation or by deprotection of a protected intermediate....	11/28/1995
5296358	Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412 The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1 to 4 carbon atoms, is carried out by the ...	03/22/1994
5079146	Method of protection of the carboxy groups in the chemistry of ଲ-lactam compounds The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of ଲ-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetox...	01/07/1992
4945159	Formation of lactams and other amides under mild conditions by action of cyanogen A method for the formation of intramolecular amide bonds by the action of cyanogen, under mild reaction conditions, in the preparation of cyclic amides, including lactams, in biologically active compounds. A compound containing at least one carboxylic aci...	07/31/1990
4775622	Expression, processing and secretion of heterologous protein by yeast Yeast organisms are caused to express, process, and secrete protein that is normally heterologous to yeast and not required for its viability by transforming yeast with an expression vector containing a gene encoding heterologous protein and a signal sequ...	10/04/1988
4340672	Enzymatic synthesis of ଲ-lactam antibacterials Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: ##STR1## (wherein RCO is an acyl group in penicill...	07/20/1982
4335211	Process for producing optically active cephalosporin analogs Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds....	06/15/1982
4073687	Enzymatic acylation to afford ଲ-lactam antibiotics Penicillin or cephalosporin antibiotics represented by following formula: ##STR1## [where ##STR2## is an acyl group derived from an ଱-amino acid, N-ammonium salt of ଱-amino acid, or N--(C1 to C10) acyl-଱-a...	02/14/1978
3945888	Method for the production of cephalosporins A new method for production of a cephalosporin ester (I) which comprises reacting a derivative of an organic acid (II) with a 7-aminocephem compound (III) in the presence of an enzyme of a microorganism of one of the genera Escherichia, Bacillus, Proteus ...	03/23/1976

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Class 435/50 - By acylation of the substituent in the 7-position