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| Number | Title | Issue Date |
| 8182985 | Anti-TSG101 antibodies and their uses for treatment of viral infections The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invent... | 05/22/2012 |
| 8182984 | Recombinant North American type 1 porcine reproductive and respiratory syndrome virus and methods of use Porcine reproductive and respiratory syndrome virus (PRRSV) is a major problem in the pork industry worldwide. The inclusion of markers in vaccines will allow for diagnostic differentiation of vaccinated animals from those naturally infected with wild-type virus. Us... | 05/22/2012 |
| 8178291 | Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the... | 05/15/2012 |
| 8173362 | Cytomegalovirus surface protein complex for use in vaccines and as a drug target Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines com... | 05/08/2012 |
| 8168379 | Application of surface plasmon resonance technology for detecting and genotyping HPV The present invention discloses using SPR technology to simultaneously and qualitatively detect different HPV genotypes. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based ... | 05/01/2012 |
| 8168386 | Methods for detecting Venezuelan equine encephalitis virus TC-83 and its use as a biological agent simulant The present invention is generally related to products and methods that facilitate the use of Venezuelan equine encephalitis (VEE) virus TC-83 (TC-83) as a non-hazardous simulant, or surrogate, for viable pathogenic viruses. Specifically, TC-83 nucleic sequences are... | 05/01/2012 |
| 8163474 | NS1-NP diagnostics of influenza virus infection The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many form... | 04/24/2012 |
| 8158341 | Efficient algorithm for PCR testing of blood samples A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an n-dimensional matrix comprising a multiplicity of elements, each element bei... | 04/17/2012 |
| 8158343 | Method to detect virus related immunological markers for the diagnosis of respiratory tract infections This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used for the diagnosis of respiratory tract infections. It also discloses... | 04/17/2012 |
| 8158342 | Method for the identification of human immunodeficiency virus related antibodies in blood This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HIV related antibodies in a serum sample for the diagnosis of HIV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance... | 04/17/2012 |
| 8153360 | Flavivirus fusion inhibitors The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various N-terminal and C-terminal chemical moieties, substituted analogs the... | 04/10/2012 |
| 8148059 | Method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker A method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker are disclosed. Firstly, a specimen is obtained from a testee. Next, the specimen is tested for its MIP-3α expression level. Then, the MIP-3α expression... | 04/03/2012 |
| 8148060 | Recombinant viral vector for gene transfer into lymphoid cells A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vec... | 04/03/2012 |
| 8142997 | Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention a... | 03/27/2012 |
| 8133666 | Method for identifying agents capable of inhibiting APOBEC3C activity in HIV-infected cells The present invention provides methods of identifying agents that reduce a level of active APOBEC3C in a cell. The present invention provides agents that reduce a level of active APOBEC3C in a cell; and compositions comprising the agents. The present invention furth... | 03/13/2012 |
| 8119338 | Methods and compositions for detecting rhinoviruses The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of human rhinovirus (HRV) in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence o... | 02/21/2012 |
| 8119339 | Heteroduplex tracking assay A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergo... | 02/21/2012 |
| 8119337 | Decreasing potential iatrogenic risks associated with influenza vaccines Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realized that the conditio... | 02/21/2012 |
| 8119336 | Compositions for use in identification of alphaviruses The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of alphaviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis. ... | 02/21/2012 |
| 8114586 | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes Conformational epitopes of the envelope proteins E1 and E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with HCV. These conserved conformational and linear epitopes of the... | 02/14/2012 |
| 8114585 | Method for determining human immunodeficiency virus (HIV) coreceptor utilization by examining gp41 molecular determinants The invention provides a method for determining whether a human immunodeficiency virus is likely to be have enhanced ability to enter a cell expressing CD4 and CXCR4 relative to a reference HIV. In certain aspects, the methods comprise detecting one or more amino ac... | 02/14/2012 |
| 8110350 | Human and methods of diagnosis and treatment Human parvovirus, genus Bocavirus, associated with respiratory tract infections in children. Nucleic acid and polypeptide sequences of the virus. Methods and products for diagnosing presence of bocavirus in a sample using nucleic acid probes or primers, or specific ... | 02/07/2012 |
| 8105767 | Cells for detection of enteroviruses The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which h... | 01/31/2012 |
| 8101342 | DNA vaccine for treating or preventing cervical cancer comprising a gene encoding HPV protein Disclosed herein is a DNA vaccine for treating cervical cancer including an E5 gene of human papillomavirus (HPV). Also, disclosed is a combination DNA vaccine for preventing and treating cervical cancer including a gene encoding HPV L1 and/or L2 along with the HPV ... | 01/24/2012 |
| 8092990 | Apparatus and method for detecting microscopic organisms using bacteriophage Methods and apparatus are provided for detection of microorganisms in a sample. Methods and apparatus of the invention are based on the specificity that phage, for example bacteriophage, have for target microorganisms, for example bacterium. Typically, phage adsorpt... | 01/10/2012 |
| 8088571 | Methods of reducing a viral infection and kits therefore A method for treating and/or preventing a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9)-susceptible viral infection comprising increasing a PCSK9 activity and/or expression in a biological system infected by the virus, whereby the increased PCS... | 01/03/2012 |
| 8080369 | Methods for activating peripheral blood mononuclear cells (PBMCs) by administering human immunodeficiency virus (HIV) Tat under physiological oxygen levels The present invention relates to methods to activate peripheral blood mononuclear cells. The present invention further provides methods for the identification of blocking agents of Tat protein activation of PBMCs and for identifying an active portion of a Tat polype... | 12/20/2011 |
| 8080370 | Screening method for prophylactic and/or therapeutic agent for disease accompanied by hepatitis C An easy and efficient screening method for an agent useful for prevention and/or treatment of hepatitis C virus-related disease, and a prophylactic and/or therapeutic agent for hepatitis C virus-related disease obtained by the method. The screening method comprises ... | 12/20/2011 |
| 8071284 | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and... | 12/06/2011 |
| 8067156 | Method for generating replication defective viral vectors that are helper free Sequences are provided that are capable of directing circular adeno-associated virus replication, useful in vectors for providing therapeutic agents to a subject in need thereof. The vectors of the invention are particularly useful in the treatment of acute medical ... | 11/29/2011 |
| 8057991 | Sequences diagnostic for shrimp pathogens Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods. ... | 11/15/2011 |
| 8057992 | Methods for identifying peptides that bind to intact oocytes Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions. Methods for identifying peptides that bind to i... | 11/15/2011 |
| 8034552 | Virulent phages to detect in foodstuffs and in food processing plants The present invention relates to virulent (lytic) Listeria monocytogenes phage from the Myoviridae family, preferably P100, alone or in combination with other virulent phages. P100 and the endolysin from P100 can be administered to food products, to the compo... | 10/11/2011 |
| 8026049 | Noninvasive measurement and identification of biomarkers in disease state The invention is methods and related kits for diagnosing a disease state of cachexia by measuring biomarker profiles from a biological sample. Rapid measurement of early onset or progression of the disease in a subject is determined by measuring biomarker levels fro... | 09/27/2011 |
| 8021834 | Use of microparticles combined with submicron oil-in-water emulsions Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submi... | 09/20/2011 |
| 8021835 | HCV coreceptor and methods of use thereof The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifyin... | 09/20/2011 |
| 8021833 | Method for reducing HIV viral budding by administering a VPS28-specfic antibody that disrupts Gag-TSG101-VPS28 binding interactions The importance of interaction between TSG101 and Vps28 in the release of HIV-1 and other viruses is disclosed. Suppressing or interfering in this interaction may inhibit HIV-1 virion release from infected cells. Agents that modulate this interaction include antibodi... | 09/20/2011 |
| 8017317 | gM-negative EHV-mutants This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceuti... | 09/13/2011 |
| 8012679 | Papillomavirus vaccines Seven polyclonal and monoclonal antibodies were characterized for their ability to react specifically with either conformational or non-conformational epitopes of the HPV-1 virion. Using these antibodies, it was shown that the HPV-1 L1 protein (when expressed by an ... | 09/06/2011 |
| 8008000 | Viral variants detection and application The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibitin... | 08/30/2011 |
