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| Number | Title | Issue Date |
| 7553635 | Process for production of cephalosporin C The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, to Acremonium chrysogenum host cells which have been transformed with suc... | 06/30/2009 |
| 7292544 | Multipoint audiovisual conferencing system According to the present invention there are provided a system, method and program storage device for establishing a connection for an endpoint to a scheduled audiovisual conference between a plurality of participants, the plurality of participants connecting to the... | 11/06/2007 |
| 7288386 | Method of determining soybean sudden death syndrome resistance in a soybean plant A method of determining the presence of soybean sudden death syndrome resistance in the soybean plant in a greenhouse setting, the method comprising the steps of: (a) inoculating soil with a low density inoculum of Fusarium solani; (b) planting a soybean plan... | 10/30/2007 |
| 7211377 | Method for detecting the presence of dormant cryptobiotic microorganisms Method for the detection of dormant cryptobiotic microbes by detection of electromagnetic radiation emitted from intrinsic alkali earth metal pyridine dicarboxylic acid salts in the 710 nm to 860 nm region when excited with electromagnetic energy in the 610 nm to 68... | 05/01/2007 |
| 6964865 | Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for β-lactam antibiotic biosynthesis DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthe... | 11/15/2005 |
| 6913901 | Procedure for controlling the enumeration of the absolute count of cells or other particles present in a sample Procedure for controlling the enumeration of the absolute count of cells (or other particles) present in a sample. The procedure consists of the following: to prepare, in known quantities and proportions, a mixture or stock solution of two or more populations of ref... | 07/05/2005 |
| 6750006 | Method for detecting the presence of microbes and determining their physiological status Method and apparatus for the detection of microbes in liquids, in air and on non-living surfaces in which samples are exposed to electromagnetic radiation of specific energies capable of exciting various metabolites, cofactors and cellular and spore components, with... | 06/15/2004 |
| 6642020 | Process for preparing cephalosporin derivatives An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula I: ##STR1## to form a 3-thiolated-glutaryl-7-ACA of the formula II ##S... | 11/04/2003 |
| 6630338 | Removing deacetylase contaminant from cephalosporin C acylase using cationic surfactant An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A deacetylase contaminant is separated from Cephalosporin C acylase using a cationic s... | 10/07/2003 |
| 6503727 | Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the... | 01/07/2003 |
| 6410259 | Process for the fermentative production of deacylated cephalosporins The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.... | 06/25/2002 |
| 6383773 | Penicillin conversion The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular, the invention defines reaction conditions under which expan... | 05/07/2002 |
| 6368820 | Process for the preparation of cephalosporins using acremonium chrysogenum An improved process for production of an N-acylated cephalosporin is described. The process utilizes an Acremonium strain which has been modified to express an acyl transferase of a filamentous fungus and is selected for production of the N-acylated cepha... | 04/09/2002 |
| 6319684 | Process for the fermentative production of cephalosporin The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the presence of a side chain precursor, extraction of the N-s... | 11/20/2001 |
| 6180360 | Process of producing ଲ-lactam antibiotics applying micro-organisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ... | 01/30/2001 |
| 6165758 | Purifying cephalosporin C acylase and regenerating a carrier immobilizing cephalosporin C acylase An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A carrier containing an immobilized enzyme is regenerated by using a protease to remov... | 12/26/2000 |
| 6071713 | Bioprocesses for preparing 7-ACA and 7-ADAC A bioprocess for preparing adipoyl-7-ACA comprising the steps: (a) transforming cells of a strain of Penicillium chrysogenum which produces isopenicillin N with an expression vector containing DNA encoding an enzyme, having expandase activity capable of a... | 06/06/2000 |
| 5942411 | Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ... | 08/24/1999 |
| 5919680 | Process for the production of SSC's via expandase activity on penicillin G An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing modified expandase enzyme.... | 07/06/1999 |
| 5804429 | Cephalosporin C acylase A mutant CC acylase wherein at least one amino acid at the Ala49, Met164, Ser166, Met174, Glu358, Met465, Met506, or Met750 position of the amino acid sequence of the ... | 09/08/1998 |
| 5780260 | Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an immobilized enzyme having a specific volume activity of at ... | 07/14/1998 |
| 5753458 | Acylation method for penicillins and cephalosporins A method for providing a semisynthetic ଲ-lactam antibiotic by enzyme catalyzed acylation of the parent ଲ-lactam with an activated derivative of the side chain acid wherein a modulator, which consists of one or more compounds different from the... | 05/19/1998 |
| 5726032 | Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expan... | 03/10/1998 |
| 5629171 | Recombinant bioprocess for the preparation of 7-amino cephalosporanic acid (7-ACA) Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in... | 05/13/1997 |
| 5599702 | D-amino acid oxidase from Trigonopsis variabilis immobilized on porous copolymer beads D-amino acid oxidase (DAO) in purified, partially purified or crude form is immobilized on a porous bead-shaped support that is a copolymer of vinyl acetate and/or vinyl alcohol and a crosslinking agent. A preferred crosslinking agent is N,N'-divinylethyl... | 02/04/1997 |
| 5597704 | Bioconversion of cephalosporin C to glutaryl-7-aminocephalosporanic acid A method of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid. The method including obtaining a cell preparation from a microorganism which produces D-amino acid oxidase, the preparation being a cell-free extract or a suspension of permea... | 01/28/1997 |
| 5559005 | Bioprocess for preparing 7-ACA and 7-ADAC Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in... | 09/24/1996 |
| 5514561 | Fluorogenic and chromogenic ଲ-lactamase substrates Chromogenic and fluorogenic substrates for ଲ-lactamase, methods for synthesis thereof and methods for detecting ଲ-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent ଲ-lactam com... | 05/07/1996 |
| 5512454 | Enzymatic acylation of 3-hydroxymethyl cephalosporins O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an ora... | 04/30/1996 |
| 5474912 | Method for increasing production of microbial metabolites by genetic engineering Targeted gene insertion methodology can increase the production of an antimicrobial metabolite and comprises the steps of: a) identifying the gene in unaltered chromosomal DNA which encodes an enzyme that catalyzes the rate controlling step in a biosynthetic p... | 12/12/1995 |
| 5466598 | Deacetylcephalosporin C acetyltransferase from Acremonium chrysogenum A DNA is disclosed, which comprises a gene coding for deacetylcephalosporin C acetyltransferase, i.e., an enzyme capable of catalyzing the final step of the biosynthesis of cephalosporin C. The gene may be either a cDNA or a genomic DNA. Also disclosed is... | 11/14/1995 |
| 5453374 | Trigonopsis transformant producing D-amino acid oxidase A Trigonopsis variabilis transformed with a recombinant DNA containing a D-amino acid oxidase gene capable of expressing in Trigonopsis variabilis is provided. A process for transforming Trigonopsis variabilis and a process for preparing 7-ଲ-(5... | 09/26/1995 |
| 5424186 | Very large scale immobilized polymer synthesis A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a first predefined region of the substrate. The irradiation of a second predefine... | 06/13/1995 |
| 5350680 | Cephalosporinase testing agent A cephalosporinase testing agent comprising a cephalosporin antibiotic, a penicillinase inhibitor in an amount of 20% by weight or less based on the weight of the cephalosporin-antibiotic, and a pH indicator which may be bromcresol purple is provided. A c... | 09/27/1994 |
| 5338667 | Microbiological process for the production of malonyl-7-amino-cephalosporanic acid derivatives using Sphingomonas sp. DSM 7007 Disclosed is a microbiological process which utilizes a biologically pure culture of Sphingomonas sp. DSM 7007 in order to produce a malonyl-7-aminocephalosporanic acid derivative product. Furthermore the process uses cephalosporin C derivative as a subst... | 08/16/1994 |
| 5336613 | Cephalosporin C acylase The present invention concerns a mutant cephalosporin C acylase derived from a precursor of the formula: A1-268 --X1 --Tyr--X2 --A272-304 --X3 --A306-773 (SEQ ID NO:1), wherein: A1-268 | 08/09/1994 |
| 5296358 | Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412 The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1 to 4 carbon atoms, is carried out by the ... | 03/22/1994 |
| 5284754 | Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivati... | 02/08/1994 |
| 5268271 | Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase Synthesis of semi-synthetic monobactamic or ଲ-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/coso... | 12/07/1993 |
| 5264346 | Colorimetric method for beta-lactamase assay and its applications A novel colorimetric method for beta-lactamase assay and its applications are disclosed. The novel assay method for beta-lactamase is based on the discovery described in this invention. The chromophore formed by oxidation of either the N-alkyl derivative ... | 11/23/1993 |
