Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 8067239 | Reagents for recombinogenic engineering and use thereof The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The methods and systems are useful, for example, in pharmaceutical drug deve... | 11/29/2011 |
| 7820443 | Fast method of transforming competent cells The invention relates to a fast method of transforming competent cells, comprising: a. mixing a plasmid DNA with the competent cells suspending within ionic solution to form a mixture; b. plating the mixture on a warm selective medium; and | 10/26/2010 |
| 7674621 | Plasmids and phages for homologous recombination and methods of use Lambda phages that can be used to introduce recombineering functions into host cells are disclosed. Also disclosed are plasmids that can be used to confer recombineering functions to a variety of strains of E. coli and to other bacteria, including Salmonel... | 03/09/2010 |
| 7435804 | Method for obtaining single chain antibodies to human interferon α2b A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the p... | 10/14/2008 |
| 7432096 | Glucose dehydrogenase and production thereof The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems. ... | 10/07/2008 |
| 7405064 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 07/29/2008 |
| 7399619 | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination Translation systems and other compositions including orthogonal aminoacyl tRNA-synthetases that preferentially charge an orthogonal tRNA with an iodinated or brominated amino acid are provided. Nucleic acids encoding such synthetases are also described, as are metho... | 07/15/2008 |
| 7393679 | Whole cell catalyst A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process for the production of this catalysts and for the production of... | 07/01/2008 |
| 7381548 | Method for producing L-amino acid using bacterium of family having expression of gene attenuated The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the yafA ge... | 06/03/2008 |
| 7371558 | Process for the biological production of 1,3-propanediol with high yield The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the cofactor requirements necessitates the use of a whole cell catalyst for... | 05/13/2008 |
| 7338801 | Double transposition methods for manipulating nucleic acids Methods are provided for manipulating nucleic acid to produce gene fusions, to delete or clone a portion of a chromosome, or to insert a sequence into a chromosome. The methods employ sequential transposition processes using two or more pairs of inverted repeat tran... | 03/04/2008 |
| 7335496 | Method for producing target substance A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modif... | 02/26/2008 |
| 7326549 | Myo-inositol oxygenases The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and method... | 02/05/2008 |
| 7326548 | Polypeptides having glucoamylase activity and polynucleotides encoding same The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for p... | 02/05/2008 |
| 7273735 | Sesquiterpene synthases and methods of use The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further... | 09/25/2007 |
| 7262046 | Aerobic succinate production in bacteria Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. ... | 08/28/2007 |
| 7262037 | Method for the production of D-(-)-3-hydroxybutyric acid by recombinant This invention relates to a method for the production of D-(−)-3-hydroxybutyric acid, comprising the step of culturing a recombinant strain containing genes phbA, phbB, ptb and buk by fermentation. Preferably, the recombinant strain is a strain of E. coli. ... | 08/28/2007 |
| 7256021 | Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammoni... | 08/14/2007 |
| 7244610 | Aerobic succinate production in bacteria Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. ... | 07/17/2007 |
| 7241600 | Process for the preparation of L-amino acids using strains of the enterobacteriaceae family The invention relates to a process for the preparation of L-amino acids, in particular L-threonine. ... | 07/10/2007 |
| 7223559 | Plasmids for chromosomal recombination of A temperature-sensitive plasmid which is capable of autonomous replication in Escherichia coli K-12 at 10–30° C., but, at a temperature of 33° C. or more, is incapable of autonomous replication in Escherichia coli K-12 or is distributed unhomogeneo... | 05/29/2007 |
| 7220588 | Method of altering levels of plasmids The present invention relates to a method of obtaining altered plasmid contents in bacteria, bearing mutation in at least one of the chromosomal genes, nusG, rho, and dnaC, and the bacterial strains thereof, having the mutated chromosomal genes, individually or in v... | 05/22/2007 |
| 7214520 | Cloning, sequencing and expression of a comamonas cyclopentanone 1,2-monooxygenase-encoding gene in Cyclopentanone 1,2-monooxygenase (CPMO) from Comamonas (previously Pseudomonas) sp. strain NCIMB 9872 carries out the second step of a degradation pathway that allows the bacterium to use cyclopentanol as a sole carbon source for growth. In the present... | 05/08/2007 |
| 7211415 | Enterobacteriaceae strains over-expressing the yfiD gene for the fermentative production of L-amino acids The present invention relates to a process for the production of L-amino acids by fermentation of recombinant microorganisms of the Enterobacteriaceae family, wherein a) the yfiD ORF and/or the pflB gene or nucleotide sequences coding for the gene produ... | 05/01/2007 |
| 7205129 | Method for reducing artifacts in nucleic acid amplification Disclosed are compositions and methods useful for reducing the formation of artifacts during nucleic acid amplification reactions. The method uses special oligonucleotides, referred to herein as template-deficient oligonucleotides, that cannot serve as a template fo... | 04/17/2007 |
| 7205149 | Gene of enzyme reactivating DNA damaged by ultraviolet light using visible light It is intended to contribute to the solution of environmental problems caused by destroying the ozone layer and serious problems concerning the food resources in the 21st century by isolating a photoreactivating enzyme from an ultraviolet light-tolerant rice plant, ... | 04/17/2007 |
| 7205130 | Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector typ... | 04/17/2007 |
| 7195895 | Method of producing template DNA and method of producing protein in cell-free protein synthesis system using the same Provided is a method of producing a template DNA used for protein synthesis comprising a step of amplifying a linear double-stranded DNA by polymerase chain reaction (PCR), by using a reaction solution comprising a first double-stranded DNA fragment comprising a seq... | 03/27/2007 |
| 7189543 | Method for producing cadaverine dicarboxylate Cadaverine dicarboxylate is produced by performing an enzymatic decarboxylation reaction of a lysine solution while adding a dicarboxylic acid containing 4 to 10 carbons to the lysine solution to maintain pH of the solution at a level sufficient for the enzymatic de... | 03/13/2007 |
| 7183089 | Method for enhancing production of isoprenoid compounds The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of hydroxymethylglutaryl-CoA (HMG-CoA) in the cell, such that the level of HMG-CoA is... | 02/27/2007 |
| 7176029 | Cloning and/or sequencing vector A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison. ... | 02/13/2007 |
| 7144998 | Clostridium perfringens beta-2 toxin signal sequence, promoter and recombinant prokarote host cells comprising them Recombinant polypeptides are prepared using novel nucleic acids with transcription promoter activity. The recombinant cells containing said nucleic acids are described. A novel method for preparing antigens or antigen fragments, in particular bacterial toxins, prefe... | 12/05/2006 |
| 7105290 | Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and a type I BMP receptor The present invention relates to a method for determining whether a compound is capable of binding to a BMP receptor kinase protein complex, the method comprising introducing a sample comprising the compound to the BMP receptor kinase protein complex and allowing th... | 09/12/2006 |
| 7101713 | DNA transformation efficiency by inhibiting host cell restriction It can be difficult to achieve efficient transformation of many strains of bacterial cells due in part to the presence of one or more restriction and modification (R-M) systems in the cells that restricts unmodified transforming DNA. Phage T7 OCR protein is a potent... | 09/05/2006 |
| 7098033 | Fast method of transforming competent cells A fast method of transforming competent cells is described. The competent cells are thawed at room temperature or in a water bath. Plasmid DNAs and competent cells are mixed together, then the mixture is subject to heat shock treatment. After plating the mixture on ... | 08/29/2006 |
| 7056729 | Botulinum neurotoxin-substance P conjugate or fusion protein for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 06/06/2006 |
| RE39114 | Expression of sucrose phosphorylase in plants Introducing sucrose phosphorylase activity into plants by transformation with a gene for the enzyme increases the rate of sucrose hydrolysis, leading to increased starch, oil, and/protein levels. Sucrose phosphorylase genes from Streptococcus mutans and Leuconostoc ... | 05/30/2006 |
| 6995045 | Thin film transistor and method of forming thin film transistor The thin film transistor has a non-transparent structure besides and insulated with the gate. Hence, the light transmitted from the substrate is blocked and the light current induced in the thin film transistor is negligible. The method uses a mask with a slit patte... | 02/07/2006 |
| 6984514 | Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine L-Glutamic acid, L-proline or L-arginine is produced by culturing a bacterium belonging to the genus Escherichia, which is L-isoleucine auxotrophic and has ability to produce L-glutamic acid, L-proline or L-arginine, in a medium containing L-isoleucine, to produce a... | 01/10/2006 |
| 6964845 | Thermostable phage lambda operator mutants for regulating gene expression The present invention concerns a method for selecting New PR or PL operator sequences from lambdoid phages which have different thermostability compared to the wild-type sequence with regard to binding a repressor. In addition new mutated P | 11/15/2005 |
