Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 7378256 | promoter for expressing genes in host cells The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the same. ... | 05/27/2008 |
| 7326542 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 02/05/2008 |
| 7323340 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 01/29/2008 |
| 7217511 | Methods of increasing antibiotic production in by deletion of the scbA gene Methods are provided for increasing and altering the timing of antibiotic production in Streptomyces species, particularly S. coelicolor and S. lividans, by functionally deleting the S. coelicolor scbA and scbR genes, respectively, or the... | 05/15/2007 |
| 6969611 | Methods to prepare cells comprising heterologous polyketide synthase expression systems Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the ... | 11/29/2005 |
| 6942986 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 09/13/2005 |
| 6872526 | High throughput screening for novel Bioactivities Disclosed is a process for identifying clones having a specified activity of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly isolated from the environment; and (ii) screening said libraries utilizi... | 03/29/2005 |
| 6511841 | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of ... | 01/28/2003 |
| 6500644 | Method for in vivo production of a mutant library in cells A method for in vivo production of a library in cells comprising a multitude of mutated genetic elements, wherein an error-prone polymerase is used in each ancestral cell to replicate all or a part of a genetic element independently of the host chromosoma... | 12/31/2002 |
| 6482632 | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain spe... | 11/19/2002 |
| 6399382 | Recombinant production of novel polyketides Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn ca... | 06/04/2002 |
| 6391594 | Modified modular PKS with retained scaffold Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically act... | 05/21/2002 |
| 6372888 | Antifungal proteins Antifungal proteins which are analogues of the Rs-AFP2 protein and contain particular mutations in their amino acid sequence. The mutated proteins possess enhanced salt-tolerant antifungal activity. The proteins are useful for combating fungal diseases in... | 04/16/2002 |
| 6204063 | Plant glycolysis and respiration enzymes This invention relates to an isolated nucleic acid fragment encoding a glycolysis or respiration protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the glycolysis or respiration protein, in sense or ant... | 03/20/2001 |
| 6197591 | Streptomyces avermitilis regulatory genes for increased avermectin production The present invention is directed to compositions and methods for producing avermectins, and is primarily in the field of animal health. The present invention relates to the identification and characterization of two novel genes, herein referred to as the... | 03/06/2001 |
| 6171846 | Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use The invention concerns mutant microorganisms blocked in a step of Streptogramin biosynthesis and methods for preparing cells blocked in a step of Streptogramin biosynthesis.... | 01/09/2001 |
| 6048694 | Bacterial positive selection vector A positive selection vector is provided for the transformation and screening of Gram positive bacteria and particularly Bacillus sp. for the presence of foreign DNA. The vector comprises a mutant gene encoding a signal peptide processing mutation. Express... | 04/11/2000 |
| 6033883 | Production of polyketides in bacteria and yeast Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of impro... | 03/07/2000 |
| 6022703 | Expression of DNA sequences derived from nocardioform microorganisms A cloning vector contains a DNA sequence derived from a Nocardioform microorganism, and is capable of expressing the DNA sequence in a host microorganism. Recombinant cholesterol oxidase is produced by a host microbial cell transformed with a cloning vect... | 02/08/2000 |
| 5876991 | Polyketide synthase genes A DNA molecule isolated from Streptomyces fradiae encodes the multi-functional proteins which direct the synthesis of the polyketide tylactone.... | 03/02/1999 |
| 5871983 | Glucosyltransferase gene GTFE from amycolatopsis orientalis The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and... | 02/16/1999 |
| 5827702 | Ocular gene therapy The invention relates to methods of ocular gene therapy.... | 10/27/1998 |
| 5756326 | Method of transformation of nocardia lactamdurans A method is disclosed for the high efficiency transformation of species of the genus Nocardia with DNA molecules. DNA vectors for the transformation of genes into Nocardia as well as recombinant Nocardia host cells expressing recombinant genes are disclos... | 05/26/1998 |
| 5741675 | Regulatory nucleic acid sequences and uses in actinomycetes Novel nucleic acid sequences, vectors for expressing same, and uses of said sequences, in particular in actinomycetes fermentation methods.... | 04/21/1998 |
| 5695976 | Stable integration of DNA in bacterial genomes A bacterial cell which in its genome carries an integrated non-replicative DNA construct comprising (1) a DNA sequence of interest, (2) a DNA sequence which is homologous with a region of the genome of the cell, and (3) an origin of replication, the DNA c... | 12/09/1997 |
| 5660999 | P0438, a new calcium-regulated promoter There is disclosed a new calcium-regulated promoter to be used for increasing production of extracellular enzymes, or heterologous polypeptide, a recombinant vector that includes the DNA sequence of the promoter operatively linked to a DNA encoding said e... | 08/26/1997 |
| 5622866 | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces The present invention is directed to expression cassettes useful in gene expression studies in both homologous and heterologous Streptomyces strains. More specifically the present invention is directed to the construction of two Streptomyces lividans-reco... | 04/22/1997 |
| 5435730 | Gal operon of streptomyces A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter; P2 promoter; P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.... | 07/25/1995 |
| 5393665 | Methods for transforming streptomyces and other actinomycetes Novel vectors and methods for a single-stranded DNA mediated gene transfer system via transformation, fusion or transduction of Streptomyces, other actinomycetes, and E. coli using a variety of vectors. Phasmid shuttle vectors of the invention are particu... | 02/28/1995 |
| 5336607 | Regulated gene expression in streptomycetes The kil-kor system from the plasmid pIJ101 can be utilized for regulated gene expression in Streptomycetes. For this, the KorA protein is either inactivated or eliminated to "switch on" a particular gene.... | 08/09/1994 |
| 5273894 | Phosphinothricin-resistance gene, and its use Selection of Streptomyces viridochromogenes DSM 4112 for resistance to phosphinothricyl-alanyl-alanine (PTT) results in PTT-resistance selectants. The DNA fragment which carries the phosphinothricin(PTC)-resistance gene is obtained from the total DNA of ... | 12/28/1993 |
| 5264354 | Method for isolating transposable elements from streptomyces A novel method for isolating transposable elements was used to isolate an approximately 1.6 kb insertion sequence from Streptomyces. The method entails transforming a cell with a plasmid containing a repressor gene, so that the introduction of a transposa... | 11/23/1993 |
| 5252474 | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis, the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic informati... | 10/12/1993 |
| 5200327 | Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from streptomyces A gene expression system is used to produce heterologous biologically active proteins, in particular bioactive granulocyte macrophage colony stimulating factor ("GM-CSF"), secreted from a host selected from the Streptomyces genera. The gene expression sys... | 04/06/1993 |
| 5164305 | Streptomyces promoter and method of use thereof A DNA sequence is described, which is a promoter for Streptomyces. This promoter is stronger than the wild type and ultimately increases transcription initiation and protein expression. Typically, a nucleotide base, such as guanine, is inserted into the p... | 11/17/1992 |
| 5149639 | Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production DNA cloning shuttle vectors, including a cosmid shuttle vector, for E. coli and Streptomyces are disclosed. Specifically, disclosed shuttle vectors pAL7002 (NRRL B-18055) and pNJ1 (NRRL B-18054) contain an E. coli origin of replication, Streptomyces repli... | 09/22/1992 |
| 5118617 | SAF polypeptide, gene coding therefor, SAF promoter and expression methods for expressing foreign DNA sequences in streptomyces The cloning and characterization of a newly isolated gene, referred to as saf (secondary metabolism activation factor) is disclosed. This gene encodes a new amino acid polypeptide, referred to as the SAF polypeptide, which directly or indirectly modulates... | 06/02/1992 |
| 5093252 | Transcription terminator and related recombinant DNA vectors and transformants A transcription terminator is disclosed comprising a DNA sequence capable of functioning as a transcription terminator in a microorganism of the order Actinomycetales. These transcription terminators are functional in both gram-positive and gram-negative ... | 03/03/1992 |
| 5068189 | Recombinant DNA vectors encoding a 4"-O-isovaleryl acylase derived from a carbomycin biosynthetic gene, designated carE, for use in streptomyces and other organisms The carE gene of Streptomyces thermotolerans has been isolated and used to construct recombinant DNA expression vectors. The carE gene encodes 4"-O-isovaleryl acylase activity important in the biosynthesis of a number of useful antibiotics. The carE gene ... | 11/26/1991 |
| 5063155 | Method for producing 2"'-O-demethyltylosin The present invention discloses a method for producing a novel antibiotic, 2"'-O-demethyltylosin. The novel antibiotic, utilizing recombinant DNA technology, can be produced from a transformed mutant of a tylosin producing microorganism. By transforming f... | 11/05/1991 |
