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| Number | Title | Issue Date |
| 7335733 | Tissue cement proteins from The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful for the temporary or permanent bonding of animal tissues to each oth... | 02/26/2008 |
| 7235395 | Lactic acid bacteria as agents for treating and preventing allergy The present invention pertains to novel strains of lactic acid bacteria capable of reducing an individual's tendency to react allergic against a variety of different allergens. In particular, the present invention relates to recombinant strains of lactic acid bacter... | 06/26/2007 |
| 7214788 | Insect inhibitory proteins, fusions, and methods of use therefor Novel insect inhibitory proteins are disclosed comprising two different components, both of which are required for biological activity. Various methods of linking both components together, so that a single protein provides insect inhibitory activity, are disclosed. ... | 05/08/2007 |
| 7022827 | Xylanase, microorganisms producing it, DNA molecules, methods for preparing this xylanase and uses of the latter The invention relates to an isolated and purified culture of Bacillus sp. strain 720/1 (LMG P-14798); to xylanases obtained from this strain and xylanases obtained from derivatives and mutants of strain 720/1. The invention also relates to a DNA molecule enco... | 04/04/2006 |
| 6762040 | Method for increasing gene copy number in a host cell and resulting host cell The invention relates to a method for increasing the copy number of a chromosomally integrated expression cassette in a microbial strain without leaving antibiotic resistance markers behind in the strain, the necessary genetic constructs, and the strains resulting f... | 07/13/2004 |
| 6627226 | Dry solid medium for storage and analysis of genetic material The present invention provides for device for obtaining and storing genetic material. The device has a support and a head portion. The head portion is composed of a solid matrix for sorbing genetic material and a preserving mechanism for the protection of... | 09/30/2003 |
| 6586184 | Chimeric mutational vectors The invention is based on the discovery that recombinagenic oligonucleobases are active in prokaryotic cells that contain a strand transfer activity (RecA) and mismatch repair activity (MutS). Using this system a type of Duplex Mutational Vector termed a ... | 07/01/2003 |
| 6551800 | Recombinant materials for production of a protein toxic to fire ants A nucleic acid derived from Bacillus thuringiensis contains a nucleotide sequence that encodes a polypeptide demonstrated to be toxic to fire ants.... | 04/22/2003 |
| 6500644 | Method for in vivo production of a mutant library in cells A method for in vivo production of a library in cells comprising a multitude of mutated genetic elements, wherein an error-prone polymerase is used in each ancestral cell to replicate all or a part of a genetic element independently of the host chromosoma... | 12/31/2002 |
| 6482632 | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain spe... | 11/19/2002 |
| 6426410 | Phenol oxidizing enzymes Disclosed herein are novel phenol oxidizing enzymes naturally-produced by strains of the species Stachybotrys which possess a pH optima in the alkaline range and which are useful in modifying the color associated with dyes and colored compounds, as well a... | 07/30/2002 |
| 6387665 | Method of making a vaccine for anthrax A method of making a vaccine for anthracis that inolves a bacterial expression system and production and use of protective antigen (PA) against Bacillus anthracis. The PA immunogen is useful in a vaccine against human anthrax. The PA can be produced by an... | 05/14/2002 |
| 6331415 | Methods of producing immunoglobulins, vectors and transformed host cells for use therein The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors wh... | 12/18/2001 |
| 6316006 | Asporogenic B anthracis expression system This invention relates to a bacterial expression system for production of protective antigen (PA) against bacillus anthracis. Recombinant asporogenic B. anthracits that are derived from ƊSterne-1(pPA102) and show inability to bind the dye when grown on C... | 11/13/2001 |
| 6303382 | Formation of and methods for the production of large bacillus thuringiensis crystals with increased pesticidal activity The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis which produces a larger quantity of a crystal delta-endotoxin with greater pesticidal activity as compared to the crystal delta-endotoxin produced by the correspondi... | 10/16/2001 |
| 6297037 | Oxidatively stable alpha-amylase Novel alpha-amylase mutants derived from the DNA sequences of naturally occurring or recombinant alpha-amylases are disclosed. The mutant alpha-amylases, in general, are obtained by in vitro modifications of a precursor DNA sequence encoding the naturally... | 10/02/2001 |
| 6267966 | Vaccine production of the Bacillus anthracis protective antigen Methods of preparing recombinant Bacillus anthracis protective antigen or a variant or fragment thereof for use in vaccines is disclosed. The protein is expressed in a recombinant microorganism which comprises a sequence which encodes PA or said variant o... | 07/31/2001 |
| 6218145 | Bacterial expression systems based on plastic or mitochondrial promoter combinations A composition for expression of a protein-encoding gene in a host cell is described, making use of an heterologous regulon. This composition provides a protein-encoding gene under control of a promoter heterologous to the host cell, and a gene for an RNA ... | 04/17/2001 |
| 6204063 | Plant glycolysis and respiration enzymes This invention relates to an isolated nucleic acid fragment encoding a glycolysis or respiration protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the glycolysis or respiration protein, in sense or ant... | 03/20/2001 |
| 6083718 | Transformed industrial bacillus strains and methods for making and using them Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide ... | 07/04/2000 |
| 6051431 | Selection marker gene free recombinant strains: a method for obtaining them and the use of these strains The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indica... | 04/18/2000 |
| 6048694 | Bacterial positive selection vector A positive selection vector is provided for the transformation and screening of Gram positive bacteria and particularly Bacillus sp. for the presence of foreign DNA. The vector comprises a mutant gene encoding a signal peptide processing mutation. Express... | 04/11/2000 |
| 6027909 | Bacillus strain and sporulation assay method Mutations in the spoIII gene of B. subtilis abolish sporulation by preventing partition of a prespore chromosome into the small polar prespore compartment. The invention provides a Bacillus strain having a chromosome with two reporter genes each linked to... | 02/22/2000 |
| 5958728 | Methods for producing polypeptides in mutants of bacillus cells The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a Bacillus cell, wherein the mutant (i) comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence compri... | 09/28/1999 |
| 5955367 | Production of bacillus thuringiensis integrants The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.... | 09/21/1999 |
| 5888800 | Expression systems for commercial production of cellulase and xylanase in Bacillus subtilis and Bacillus licheniformis Increased production of a heterologous cellulase is achieved by transforming Bacillus subtilis and Bacillus licheniformis with genetic constructs containing a Bacillus licheniformis ATCC 53926 protease promoter and signal sequence to express alkalophilic ... | 03/30/1999 |
| 5885811 | Leader sequence inducing a post-translational modification of polypeptides in bacteria gene therefor and subtilin variant of enhanced stability and activity The method by which polypeptides having residues other than the 20 common amino acids are made is established. A leader peptide sequence (SEQ ID NO: 7) and its gene are identified which induce or assist post-translational modifications of Cys, Thr and Ser... | 03/23/1999 |
| 5874267 | Expression of surface layer proteins A host cell which is provided with a S-layer comprising a fusion polypeptide consisting essentially of: (a) at least sufficient of a S-layer protein for a S-layer composed thereof to assemble, and (b) a heterologous polypeptide which is fused to either the car... | 02/23/1999 |
| 5858745 | Bacillus thuringiensis transformation method Particularly effective B.t. insecticides are obtained by culturing to the sporulation stage novel transformant obtained on transforming B.t. kurstaki H.D. 562 with DNA expressing in the B.t. certain mutant endotoxin genes. Such transformants and other B.t... | 01/12/1999 |
| 5843720 | Introduction of DNA into bacillus strains by conjugation The present invention relates to methods of constructing recombinant Bacillus strains encoding a polypeptide of interest, in which method a DNA construct comprising a DNA sequence encoding the polypeptide of interest is introduced into a recipient Bacillu... | 12/01/1998 |
| 5843702 | Gene expression system The present invention relates to an expression system which comprises a phage-like bacteriocin("phibacin") or a mutant thereof, or a gene or mutant of a phibacin having a function in gene expression, such as a repressor gene, which is used to transform ba... | 12/01/1998 |
| 5840312 | Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein A recombinant strain of B. anthracis is characterized in that it can induce the production of protective antibodies against virulent strains of B. anthracis in a human or animal host, and characterized also by the mutation of the pX01 plasmid of at least ... | 11/24/1998 |
| 5756316 | Molecular cloning by multimerization of plasmids Novel methods of nucleic acid multimerization using PCR are provided, allowing direct transformation of cells and microorganisms.... | 05/26/1998 |
| 5741675 | Regulatory nucleic acid sequences and uses in actinomycetes Novel nucleic acid sequences, vectors for expressing same, and uses of said sequences, in particular in actinomycetes fermentation methods.... | 04/21/1998 |
| 5733723 | Stable gene amplification in chromosomal DNA of prokaryotic microorganisms Transformed prokaryotic hosts are provided comprising two or more copies of a DNA sequence stably maintained in their chromosome, said DNA sequence comprising a gene encoding a polypeptide of interest wherein said copies are separated by endogenous chromo... | 03/31/1998 |
| 5695976 | Stable integration of DNA in bacterial genomes A bacterial cell which in its genome carries an integrated non-replicative DNA construct comprising (1) a DNA sequence of interest, (2) a DNA sequence which is homologous with a region of the genome of the cell, and (3) an origin of replication, the DNA c... | 12/09/1997 |
| 5650308 | Recombinant Bacillus thuringiensis strain construction method A transposable element, or transposon, isolated from Bacillus thuringiensis (B.t.) and designated as transposon Tn5401. The invention also includes a method of using this transposon in a site-specific recombination system for construction of recombinant B... | 07/22/1997 |
| 5324653 | Recombinant genetic means for the production of serine protease muteins New proteolytic enzymes are provided exhibiting improved properties for application in detergents, especially laundry detergents. These enzymes are obtained by expression of a gene encoding a proteolytic enzyme having an amino acid sequence which differs ... | 06/28/1994 |
| 5270452 | Pure glia maturation factor Pure homogeneous glia maturation factor is disclosed with methods for producing it from neutral sources and by molecular cloning and genetic engineering.... | 12/14/1993 |
| 5264366 | Protease deficient bacillus There are described, normally sporulating mutant Bacillus strain(s) which produce no detectable proteolytic activity during any phase of its growth. The absence of detectable proteolytic activity is due to the deletion of one or more codons specifying the... | 11/23/1993 |
