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| Number | Title | Issue Date |
| 7425450 | Regulatable growth of filamentous fungi The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemica... | 09/16/2008 |
| 7413879 | glucoamylase and homologs thereof The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for ... | 08/19/2008 |
| 7413887 | glucoamylase and homologs thereof The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for ... | 08/19/2008 |
| 7378256 | promoter for expressing genes in host cells The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the same. ... | 05/27/2008 |
| 7364884 | Method for producing a hydroxylation catalyst and the use thereof A process for preparing a hydroxylation catalyst by i) embedding a cystochrome P450 monooxygenase in a sol-gel matrix, ii) embedding an enzymatic NADPH-regenerating system in a sol-gel matrix, and combini... | 04/29/2008 |
| 7361487 | Enzyme fusion proteins and their use Cellulase fusion proteins comprising an endoglucanase core region and a heterologous cellulose binding domain are described. The fusion proteins may be produced by recombinant techniques using appropriate polynucleotides, expressing vectors and host cells. The fusio... | 04/22/2008 |
| 7354752 | Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression of the asAA having GSH activity in filamentous fungal host cel... | 04/08/2008 |
| 7348172 | Method and DNA constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a catalytic module (CAT) and a carbohydrate binding module (CBM) separa... | 03/25/2008 |
| 7335501 | Phytases and methods for producing these phytases The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel phytases derived from fungi of the Penicillium genus, in particular ... | 02/26/2008 |
| 7332341 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells The present invention relates to mutants cells comprising a marker-free modification of a gene, and methods for obtaining and using such mutant cells. ... | 02/19/2008 |
| 7332319 | Heterologous alpha amylase expression in The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same. ... | 02/19/2008 |
| 7247441 | Nucleic acid sequence and protein in addition to polypeptides coding for mannitol dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy The invention relates to polypeptides made of mannitol-dehydrogenase of Cladosporium herbarum and Alternaria alternata nucleic acids coding therefor and the use thereof in diagnosis and therapy. ... | 07/24/2007 |
| 7220542 | Expression cloning in filamentous fungi Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are useful in processes for producing the proteins of interest. ... | 05/22/2007 |
| 7189538 | Hyphal growth in fungi The present invention provides a method for producing desired proteins or chemicals in fungal host cells, which comprise modulating the nucleic acid encoding proteins associated with hyphal growth. The amino acid and nucleic acid sequences of hbrA and hbrB are provi... | 03/13/2007 |
| 7163804 | Non-toxic non-toxigenic non-pathogenic fusarium expression system The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter... | 01/16/2007 |
| 7052913 | Matrices for drug delivery and methods for making and using the same In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-ge... | 05/30/2006 |
| 7022526 | Reducing branching and enhancing fragmentation in culturing filamentous microorganisms The invention relates to the field of microorganisms and to the culturing of microorganisms. Means and methods are described for enhancing the culturing properties of filamentous microorganisms, particularly filamentous fungi. According to the invention, the means a... | 04/04/2006 |
| 7005561 | Arabitol or ribitol as positive selectable markers Disclosed herein are novel methods and materials for selecting transgenic cells. Specifically exemplified herein are positive selection methods that involve conferring to cells the ability to metabolize certain compounds, preferably arabitol, ribitol, raffinose, suc... | 02/28/2006 |
| 6927026 | Orotidine-5′-phosphate decarboxylase-gene, gene construct containing said gene and the utilization thereof The invention relates to an orotidine-5′-phosphate decarboxylase gene having the sequence of SEQ ID NO: 1 or its homologs, to a gene construct comprising this gene or its homologs, and to its use. The invention additionally relates to vectors or organisms comprisi... | 08/09/2005 |
| 6872526 | High throughput screening for novel Bioactivities Disclosed is a process for identifying clones having a specified activity of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly isolated from the environment; and (ii) screening said libraries utilizi... | 03/29/2005 |
| 6746843 | Methods of screening novel agents for use in cancer therapy and prevention The present invention provides for methods of screening agents for cancer therapeutic and prophylactic activity. In particular embodiments, cells of the cellular slime mold Dictyostelium discoideum are contacted with candidate agents and the expression of gen... | 06/08/2004 |
| 6703200 | Methods and materials for the rapid and high volume production of a gene knock-out library in an organism The present invention relates to a method for facilitating site directed homologous recombination in an organism to produce mutants comprising: 1) providing a large insert vector library comprising one or more large insert vectors, each of said large inser... | 03/09/2004 |
| 6582951 | Method for non-homologous transformation of Yarrowia lipolytica The invention concerns the integration of a gene of interest into the genome of a Yarrowia strain devoid of zeta sequences, by transforming said strain using a vector bearing zeta sequences.... | 06/24/2003 |
| 6558921 | Promoters of the genes glutamate deshydrogenase, ଲ-N-acetylhexosaminidase and γ-actin and their use in filamentous fungi expression, secretion and antisense systems An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is capable of directing expression of DNA downstream of the fra... | 05/06/2003 |
| 6500644 | Method for in vivo production of a mutant library in cells A method for in vivo production of a library in cells comprising a multitude of mutated genetic elements, wherein an error-prone polymerase is used in each ancestral cell to replicate all or a part of a genetic element independently of the host chromosoma... | 12/31/2002 |
| 6436643 | Process for site-directed integration of multiple copies of a gene in a mould A process for site-directed integration of multiple copies of a gene in a mould is provided, which comprises transforming a mould cell containing in its chromosomal DNA a restriction site for a rare-cutting endonuclease, e.g., I-Scel, preferably introduce... | 08/20/2002 |
| 6426410 | Phenol oxidizing enzymes Disclosed herein are novel phenol oxidizing enzymes naturally-produced by strains of the species Stachybotrys which possess a pH optima in the alkaline range and which are useful in modifying the color associated with dyes and colored compounds, as well a... | 07/30/2002 |
| 6379924 | Protein expression strains The use of a means to vary Ubc4p or Ubc5p activity in a fungal cell to control the copy number of a plasmid in the cell. The level of Ubc4p or Ubc5p activity may be reduced/abolished (for example by gene deletion, mutagenesis to provide a less active prot... | 04/30/2002 |
| 6316695 | Isopentenyl diphosphate isomerase from Hevea brasiliensis and rubber producing method using the same The present invention cloned a cDNA clone encoding isopentenyl diphosphate (hereafter "IPP") isomerase (EC 5.3.3.2) from a cDNA library of Hevea brasiliensis latex. The clone has a continuous open reading frame encoding a peptide of 234 amino acids with a... | 11/13/2001 |
| 6300095 | Promoters of the genes glutamate dehydrogenase ଲ-N-acetylhexosaminidase and γ-actin and their use in filamentous fungi expression, secretion and antisense systems The invention relates to promoters of the genes glutamate dehydrogenase, ଲ-acetylhexosaminidase and γ-actin and their use in systems of expression, secretion and anti-sense of filamentary fungi. The invention also relates to the use of the promoter... | 10/09/2001 |
| 6291209 | Alkaline protease deficient filamentaous fungi The present invention relates to a filamentous fungus useful for the production of heterologous polypeptides, having been modified by recombinant DNA technology in a manner by which the expression of alkaline proteases have been completely or partially in... | 09/18/2001 |
| 6258555 | DNA encoding ACV synthetase DNA encoding the gene for the synthetase enzyme capable of generating δ (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenu... | 07/10/2001 |
| 6255115 | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus The invention relates to Agrobacterium mediated transformation of moulds comprising species of the fungal sub-divisions Ascomycotina, Basidiomycotina, Deuteromycotina, Mastigomycotina, and Zygomycotina. Examples demonstrate the transformation of Aspergillus aw... | 07/03/2001 |
| 6111081 | Lactoferrin variants and uses thereof The present invention is directed to recombinant nucleic acids encoding lactoferrin variants and portions thereof, having modified iron-binding capacity, and to vectors comprising same recombinant nucleic acids. The present invention is further directed t... | 08/29/2000 |
| 6103490 | Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fung... | 08/15/2000 |
| 6033883 | Production of polyketides in bacteria and yeast Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of impro... | 03/07/2000 |
| 6027910 | Process for immobilizing enzymes to the cell wall of a microbial cell by producing a fusion protein A method is provided for immobilizing an enzyme, comprising immobilizing the enzyme or a functional part thereof to the cell wall of a microbial cell using recombinant DNA techniques. The enzyme is immobilized by linking it to the C-terminal part of a pro... | 02/22/2000 |
| 6025185 | Fungus wherein the areA gene has been modified and an areA gene from Aspergillus oryzae A modified Aspergillus oryzae cell having an area gene which does not express a functional AreA activator, DNA sequences encoding the area gene, and method for using the cell of the invention for production of a heterologous polypeptide.... | 02/15/2000 |
| 6022725 | Cloning and amplification of the ଲ-glucosidase gene of Trichoderma reesei A process for expressing extracellular ଲ-glucosidase in a filamentous fungus by expressing a fungal DNA sequence encoding enhanced, deleted or altered ଲ-glucosidase in a recombinant host microorganism is disclosed. Recombinant fungal cellulase... | 02/08/2000 |
| 6017762 | Cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica The present invention relates to a new cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica, to a strain of this species transformed with this cassette, to a process for preparing endothiapepsin using this strain and also... | 01/25/2000 |
