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| Number | Title | Issue Date |
| 8143061 | Industrial method for producing RNA and system for carrying out said method The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription... | 03/27/2012 |
| 7666678 | Proteins imparting boron-tolerance and genes thereof The present invention provides genes and proteins having possibilities to generate plants having tolerance against excessive boron, which can confer a boric acid tolerance to organisms. 5 types of genes that can confer a boric acid tolerance to yeast, such as AtPAB2... | 02/23/2010 |
| 7435168 | Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ... | 10/14/2008 |
| 7429469 | Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene i... | 09/30/2008 |
| 7425450 | Regulatable growth of filamentous fungi The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemica... | 09/16/2008 |
| 7381551 | mutant The present invention relates to a method for improved ethanol production from xylose utilizing strain of Saccharomyces cerevisiae comprising genes for overexpression of xylose reductase, xylitol dehydrogenase and xylulokinase, wherein in addition to said gen... | 06/03/2008 |
| 7371851 | Methods of cloning and producing fragment chains with readable information content The present invention provides a method of attaching a fragment of a first nucleic acid molecule to a second nucleic acid molecule using adapters to mediate the binding particularly in methods of cloning, methods of producing fragment chains with a readily readable ... | 05/13/2008 |
| 7335501 | Phytases and methods for producing these phytases The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel phytases derived from fungi of the Penicillium genus, in particular ... | 02/26/2008 |
| 7326549 | Myo-inositol oxygenases The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and method... | 02/05/2008 |
| 7297513 | Gene encoding glutathione synthetase from A gene encoding glutathione synthetase from Candida utilis is provided and food containing γ-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a sui... | 11/20/2007 |
| 7279334 | Methods for inducing targeted stimulation of meiotic recombination and kits for performing said methods The Invention pertains to methods, kits, molecules and cells to increase the rate or recombination and/or target recombination in dividing cells. In a particular aspect, the invention concerns methods and kits to induce targeted meiotic recombination. ... | 10/09/2007 |
| 7273737 | -prenyltransferases from plants This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, th... | 09/25/2007 |
| 7273747 | Cell having amplified signal transduction pathway responses and uses therefor The invention provides recombinant cells that have been engineered such that ligand stimulation of a receptor expressed by the cells leads to amplified signal transduction responses. In one embodiment, the receptor-expressing cells have been engineered to carry a he... | 09/25/2007 |
| 7267976 | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) a... | 09/11/2007 |
| 7259007 | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolated ... | 08/21/2007 |
| 7256014 | Method to increase hydrophobic compound titer in a recombinant microorganism Expression of at least one plant oleosin gene in a microbial cell engineered to produce hydrophobic/lipophilic compounds significantly increases the overall titer of the compound. The hydrophobic nature of the oleosin core is believed to increase the microbial host ... | 08/14/2007 |
| 7253001 | Metabolic engineering for improved xylose utilisation of The present invention relates to a method for preparing an ethanol producing, xylose utilizing strain of Saccharomyces cerevisiae comprising genes for overexpression of xylose reductase, xylitol dehydrogenase and xylulokinase, wherein in addition to said gene... | 08/07/2007 |
| 7250263 | Methods and compositions for identifying receptor effectors The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screeni... | 07/31/2007 |
| 7189559 | lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms Lysophosphatidic acid acyltransferase (LPAAT) participates in the second step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids produced in oils of oleaginous organisms. The present application ... | 03/13/2007 |
| 7169585 | Papillomavirus vaccine A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recombinant DNA... | 01/30/2007 |
| 7153433 | Use of functionalized porous membranes or matrices for purification of nucleic acids and corresponding methods Application of a functionalized porous membrane to purify nucleic acids, the binding properties of the membrane with respect to nucleic acids being adjustable by controlling the conditions of an ambient medium. The membrane is functionalized by deprotonated groups. | 12/26/2006 |
| 7148053 | Heterologous G protein coupled receptors expressed in yeast, their fusion with G proteins and use thereof in bioassay Expression vectors and yeast cells that contain a heterologous G protein-coupled receptor gene and a gene mutation that causes increased sensitivity to receptor activation or a gene mutation that permits transcriptional activation of pheromone-responsive genes witho... | 12/12/2006 |
| 7090994 | Methods of screening for introduction of DNA into a target cell The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant targe... | 08/15/2006 |
| 7070967 | High speed, consecutive batch or continuous, low effluent process for the production of ethanol from molasses, starches, or sugars A flocculent Saccharomyces cerevisae strain (BPSC-15) produces higher yields of ethanol in fermentations of fermentable sugar or fermentable starch/enzyme. ... | 07/04/2006 |
| 7052900 | yeast strain with functional expression of a Glut transporter The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source... | 05/30/2006 |
| 7033814 | Methods for preparing yeast with improved biotin productivity using integrating plasmids encoding biotin synthase Methods for preparing yeast with improved biotin productivity using integrating plasmids encoding biotin synthase. The yeast is transformed by an integrating plasmid, which includes a Candida utilis biotin synthase gene BIO2, an assistant DNA sequence to prom... | 04/25/2006 |
| 7018829 | Metabolically engineered microbial cell with an altered metabolite production A recombinant microbial cell comprises at least one increased expressible enzyme activity controlling anabolic metabolism of ammonia as a nutrient source, the increased enzyme activity being an NADH-dependent activity catalysing the reaction ... | 03/28/2006 |
| 7009045 | Transformation systems for flavinogenic yeast This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata, and mutants thereof, by electroporation (electrotransformation) and by spheroplast transformation. The invention is also directed to ... | 03/07/2006 |
| 7005561 | Arabitol or ribitol as positive selectable markers Disclosed herein are novel methods and materials for selecting transgenic cells. Specifically exemplified herein are positive selection methods that involve conferring to cells the ability to metabolize certain compounds, preferably arabitol, ribitol, raffinose, suc... | 02/28/2006 |
| 6998261 | Functional gene array in yeast This invention relates to functional gene arrays of yeast. Novel aspects include the individual yeast cells, methods for making the yeast and the arrays, the arrays and uses for the arrays. A diploid bearing special genetic properties has been constructed to facilit... | 02/14/2006 |
| 6987026 | Vector for the transformation of and process of transformation thereby The present invention is directed to a recombinant vector for transforming yeast and a process for transforming yeast thereby, more particularly to a recombinant vector comprising a gene encoding a mutated L41 protein having cycloheximide-resistant activity and a ri... | 01/17/2006 |
| 6921666 | Methods for generating hypermutable yeast Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but ... | 07/26/2005 |
| 6902882 | Methods of monitoring production of gene products and uses thereof This invention relates generally to the field of monitoring production of gene products. In particular, the invention provides methods of monitoring production of a gene product, methods of screening for modulators of production of a gene product, and methods of scr... | 06/07/2005 |
| 6884602 | Expression of alkaline phosphatase in yeast This invention involves a process for selecting and producing eukaryotic alkaline phosphatase in yeast. Yeast cells are subjected to multiple transformations using a vector comprising a first resistance marker gene and the alkaline phosphatase gene. Those strains th... | 04/26/2005 |
| 6855550 | Expression of G protein coupled receptors in yeast Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protean coupled receptor and a second heterologous DNA sequence which codes for a mammalian G protein α subunit (mammalian Gα). The first an... | 02/15/2005 |
| 6844193 | Isolated FGF receptor Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine recept... | 01/18/2005 |
| 6828112 | Method of detecting protein-protein interactions A method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other. The interaction between the two fusion proteins leads to protein trans-splicing, generating an active and detectable r... | 12/07/2004 |
| 6803225 | Protein glycosylation modification in Pichia pastoris The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an (α-1,2-mannos... | 10/12/2004 |
| 6800476 | Regulated expression of PKC and/or SRB1/psa1 in yeast The present invention relates to yeast cells containing the SRB1/PSA1 gene and/or the PKC1 gene or functional derivatives thereof operatively linked to a heterologous inducible promoter and also to methods of regulating yeast cell lysis and flocculation and methods ... | 10/05/2004 |
| 6797488 | Methods of producing anti-angiogenic proteins Methods for making proteins with anti-angiogenic properties are disclosed. The system used is a yeast expression system which produces biologically active proteins at high titer. ... | 09/28/2004 |
