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| Number | Title | Issue Date |
| 7183105 | Eubacterial minicells and their use as vectors for nucleic acid delivery and expression Th invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and agents for drug discovery. ... | 02/27/2007 |
| 7176029 | Cloning and/or sequencing vector A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison. ... | 02/13/2007 |
| 7135176 | VMP-like sequences of pathogenic The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequence... | 11/14/2006 |
| 7125720 | Plasmid maintenance system for antigen delivery The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression pla... | 10/24/2006 |
| 7122350 | Methods for enhancing expression of recombinant proteins The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant... | 10/17/2006 |
| 6977176 | Plasmid maintenance system for antigen delivery The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression pla... | 12/20/2005 |
| 6855513 | Quorum sensing signaling in bacteria The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginos... | 02/15/2005 |
| 6682729 | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same A method for introducing and expressing genes in animal cells is disclosed comprising infecting the animal cells with live invasive bacteria, wherein the bacteria contain a eukaryotic expression cassette encoding the gene. The gene may encode, e.g., a vac... | 01/27/2004 |
| 6617163 | Polynucleotides for mutagenesis in fungus comprising a functional gene in magnaporthe and an impala transposon The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterized Fusarium oxysporum Impala transposon in the genome of said fungi. The invention also concerns th... | 09/09/2003 |
| 6605701 | Pesticidal toxins and genes from Bacillus laterosporus strains Disclosed and claimed are novel toxins and genes obtainable from Bacillus laterosporus isolates disclosed herein. In preferred embodiments, the subject genes and toxins are used to control Western corn rootworm.... | 08/12/2003 |
| 6602712 | Enterotoxin-deficient bacillus A enterotoxin-deficient mutant of a member strain of the Bacillus cereus group does not produce HBL enterotoxin, which has been regarded as a human pathogen found in member strains. An enterotoxin-deficient mutant is suitable for use as a biocontrol agent... | 08/05/2003 |
| 6593141 | Scorpion toxins This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel modifiers. The invention also relates to the construction of a chimeric gene encoding all or a substantial portion of the K-channel modifier, in sense ... | 07/15/2003 |
| 6548246 | Method and probes for the identification of microbial genes specifically induced during host infection The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular coding sequences or defined regions thereof may be used as ... | 04/15/2003 |
| 6521458 | Compositions and methods for improved plant transformation The present invention provides methods for eliminating plants containing non-T-DNA sequences derived from a T-DNA vector. More specifically, the present invention provides a method for killing plant cells that receive non-T-DNA sequences based on incorpor... | 02/18/2003 |
| 6503500 | Biocontrol agent containing an endotoxin gene The invention provides a biocontrol agent against larvae of mosquitoes and blackflies comprising transgenic Anabaena PCC 7120 carrying a synergistic combination of the endotoxin genes CryIVA and CryIVD of Bacillus thuringiensis subsp. israelensis.... | 01/07/2003 |
| 6297369 | Pesticidal toxins and genes from Bacillus laterosporus strains Disclosed and claimed are novel toxins and genes obtainable from Bacillus laterosporus isolates disclosed herein. In preferred embodiments, the subject genes and toxins are used to control Western corn rootworm.... | 10/02/2001 |
| 6267966 | Vaccine production of the Bacillus anthracis protective antigen Methods of preparing recombinant Bacillus anthracis protective antigen or a variant or fragment thereof for use in vaccines is disclosed. The protein is expressed in a recombinant microorganism which comprises a sequence which encodes PA or said variant o... | 07/31/2001 |
| 6252138 | Pathogen-induced plant promoters New pathogen-induced promoters are provided, particularly nematode-induced promoters, which are characterized by their selective induction of expression in the vicinity of the pathogen infection sites, such as the fixed feeding cells induced by infection ... | 06/26/2001 |
| 6239329 | Shoot meristem specific promoter sequences A novel tissue-specific promoter is provided which has been isolated from the upstream non-coding region of a plant UFO gene. This promoter, operably associated with a nucleic acid sequence expressing a product of interest, initiates and regulates the tra... | 05/29/2001 |
| 6207167 | Chicken leucocytozoon vaccine A vaccine strain OU5758 is provided which includes an attenuated immunogenic plasmidless Salmonella enterica serovar-Typhimurium strain OU5046 harboring a recombinant plasmid pOU1500 for immunizing a chicken against leucocytozoonosis. The strain OU5046 is... | 03/27/2001 |
| 6180407 | Cloning and/or sequencing vector A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison.... | 01/30/2001 |
| 6150170 | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same A method for introducing and expressing genes in animal cells is disclosed comprising infecting said animal cells with live invasive bacteria, wherein said bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a ... | 11/21/2000 |
| 6090562 | Recombinant clone selection system Cloning systems useful for the isolation of recombinant nucleic acid are disclosed in which the recombination of cloning-system nucleic acid and foreign nucleic acid is linked to the expression of a moiety on the surface of a host organism, the moiety bei... | 07/18/2000 |
| 5965381 | Delivery of proteins into eukaryotic cells with recombinant yersinia The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.... | 10/12/1999 |
| 5955332 | Nucleic acid sequences and plasmids comprising at least one phage resistance mechanism, bacteria containing them and their use The invention relates to polynucleotides of 1345 bp and 3704 bp and the like, which comprise at least one phage resistance mechanism and obtainable from the total DNA contained in the Lactococcus lactis ssp cremoris strain deposited in the CNCM under No. ... | 09/21/1999 |
| 5928891 | DNA fragment encoding insecticidal crystal proteins from Bacillus thuringiensis The invention relates to a vector for transforming microorganisms capable of undergoing sporulation and which contains itself a heterologous insert comprising a DNA sequence coding for at least part of crystal protein, particularly that of B. thuringensis... | 07/27/1999 |
| 5922603 | Method for obtaining strains of trichoderma species Strains of Trichoderma spp. that are improved in their capacity as biological control agents for phytopathogenic fungi and nematodes are obtained that are able to over-produce a proteinase, with the aid of a transformation method which involves introducin... | 07/13/1999 |
| 5922583 | Methods for production of recombinant plasmids The invention relates to a culture system for stable and high-level production of DNA contained on recombinant plasmids, and to the bacteria and plasmids which comprise the culture system. The bacterial cell chromosome is irreversibly altered, in one embo... | 07/13/1999 |
| 5891688 | DNA encoding lemA-independent GacA and its use in activating gene expression The present invention exploits the discovery that certain single base changes in the gacA gene coding sequence, which result in certain single amino acid changes in the encoded GacA protein, render it LemA-independent. The present invention therefore prov... | 04/06/1999 |
| 5882653 | Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof Avirulent Vibrio cholerae strains of O1 (CVD111) and non-O1 (CVD112 and CVD112RM) serogroups having the DNA of the cholera toxin core and the RS1 sequences of the cholera toxin locus deleted, and further having a DNA encoding a resistance to mercury, and ... | 03/16/1999 |
| 5877159 | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same A method for introducing and expressing genes in animal cells is disclosed comprising infecting said animal cells with live invasive bacteria, wherein said bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a ... | 03/02/1999 |
| 5840312 | Recombinant Bacillus anthracis strains unable to produce the lethal factor protein or edema factor protein A recombinant strain of B. anthracis is characterized in that it can induce the production of protective antibodies against virulent strains of B. anthracis in a human or animal host, and characterized also by the mutation of the pX01 plasmid of at least ... | 11/24/1998 |
| 5840554 | ଲ-Endotoxin expression in pseudomonas fluorescens Bacillus thuringiensis endotoxin expression in Pseudomonads can be improved by modifying the gene encoding the Bacillus thuringiensis endotoxin. Chimeric genes are created by replacing the segment of the Bacillus thuringiensis gene encoding a native proto... | 11/24/1998 |
| 5807723 | Homologously recombinant slow growing mycobacteria and uses therefor A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method... | 09/15/1998 |
| 5766904 | Phage-resistant streptococcus DNA fragment of phages which are virulent towards a Streptococcus, capable of conferring on a Streptococcus containing it resistance to at least one phage, especially a fragment homologous or hybridizing to the 3.6 kb HindIII fragment present in the plasm... | 06/16/1998 |
| 5763247 | Nucleotide fragments and uses thereof for obtaining bactericide-producing compositions Nucleotide fragments which encode a bacteriocin composition derived from Micrococcus varians and for preparing compositions to obtain the bacteriocin and for obtaining recombinant microorganisms. The nucleotide fragments include, in particular, nucleotide... | 06/09/1998 |
| 5686283 | Genomic DNA encoding the pseudomonas fluorescens alternative sigma factor, RpoS, capable of activating gene expression Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to produce several metabolites and may be transferred to bacteria... | 11/11/1997 |
| 5686282 | DNA encoding the pseudomonas fluorescens sensor/kinase element, lemA, and its use in activating gene expression Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to produce several metabolites and may be transferred to bacteria... | 11/11/1997 |
| 5670370 | Biological containment A replicon, in which a nucleotide sequence encoding a cell killing function is regulatably expressed when the replicon is harboured in one type of host cell (primary host cell), so that cells harbouring the replicon are killed under conditions under which... | 09/23/1997 |
| 5591616 | Method for transforming monocotyledons A method for transforming a monocotyledon by which the time required from transformation to regeneration of a plant is shorter so that the frequency of emergence of mutants is smaller than the conventional methods, which may be generally applied even to t... | 01/07/1997 |
